1.Validation of Serum Aminotransferases Levels to Define Severe Dengue Fever in Children.
Geetika SRIVASTAVA ; Nanda CHHAVI ; Amit GOEL
Pediatric Gastroenterology, Hepatology & Nutrition 2018;21(4):289-296
PURPOSE: We aimed to study the pattern of liver-injury in children with dengue fever (DF) and validate serum aminotransferase ≥1,000 IU/L as a marker of severe DF. METHODS: Children admitted with DF were included. DF was defined by presence of clinical criteria and positive serological or antigen tests in absence of other etiology. DF severity was graded as dengue without or with warning signs and severe dengue. Liver-injury was defined as alanine aminotransferase (ALT) more than twice the upper limit of normal (boys, 30 IU/L; girls, 21 IU/L). RESULTS: Of 372 children with DF, 144 (38.7%) had liver-injury. Risk of liver-injury and aminotransferase levels increased with DF severity (p < 0.001). Recommended ALT and aspartate aminotransferase (AST) cut-off at ≥1,000 IU/L had sensitivity 4.8% (5/105), specificity 99.3% (265/267) for detection of severe DF. In children with ALT and AST < 1,000 IU/L (n=365), the area under receiver operating curves for prediction for severe DF, were 0.651 (95% confidence interval [CI], 0.588–0.714; p < 0.001) for ALT and 0.647 (95% CI, 0.582–0.712; p < 0.001) for AST. Serum ALT at 376 IU/L and AST at 635 IU/L had sensitivity and specificity comparable to ≥1,000 IU/L for defining severe DF. CONCLUSION: Liver-injury is common in DF. The ALT and AST levels increase with DF severity. ALT and AST levels of ≥1,000 IU/L could be lowered to 376 IU/L and 635 IU/L respectively for defining severe DF.
Alanine Transaminase
;
Arboviruses
;
Aspartate Aminotransferases
;
Child*
;
Dengue
;
Female
;
Fever*
;
Humans
;
Sensitivity and Specificity
;
Severe Dengue*
;
Transaminases*
2.A Case of Dengue Hemorrhagic Fever Imported from Africa.
Seong Ryul KWON ; Byung Kwan CHO ; Seung Jai YOON ; Yong Bum CHO ; Il Kwon KIM ; Byong Joon PARK ; Moon Hyun CHUNG
Korean Journal of Infectious Diseases 2000;32(6):467-469
Dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) is an acute febrile illness characterized by hemorrhagic phenomenon and hypovolemic shock due to increased vascular permeability and plasma leakage in patients infected with any one of four serotypes of dengue virus. The disease is one of the principal causes of hospitalization and death among children in several south-east Asian, central and south American, and African countries. With increasing use of air or ship transport, more travelers and sailors to the tropics are returning within the incubation period of acute febrile infection. Herein we reported the first Korean case of dengue hemorrhagic fever imported from Africa. We experienced a Korean sailor who complains of fever, chill, nausea, and epistaxis after the return from Mombasa, Kenya. His fellows also showed the similar complains. His illness improved spontaneously and the indirect immunofluorescent antibody testing revealed antibody titer of 1:1024 or more.
Africa*
;
Asian Continental Ancestry Group
;
Capillary Permeability
;
Child
;
Dengue Virus
;
Dengue*
;
Epistaxis
;
Fever
;
Hospitalization
;
Humans
;
Kenya
;
Military Personnel
;
Nausea
;
Plasma
;
Severe Dengue*
;
Ships
;
Shock
3.A Case of Dengue Fever.
Boncheol GOO ; Sang Gun PARK ; Kee Yang CHUNG
Korean Journal of Dermatology 2005;43(10):1371-1374
Dengue fever is caused by the dengue virus which belongs to the flaviviridae family and is transmitted by mosquitos. It occurs in the tropical climates of central and south america, asia, and africa and is considered one of the most important arthropod-borne viral diseases as regards morbidity and mortality, especially due to its hemorrhagic forms, dengue hemorrhagic fever and dengue shock syndrome. We report a case of dengue fever which presented with typical systemic symptoms and signs such as fever, headache, nausea and characteristic erythroderma (white islands in a sea of red) on travelling Bangladesh.
Africa
;
Asia
;
Bangladesh
;
Culicidae
;
Dengue Virus
;
Dengue*
;
Dermatitis, Exfoliative
;
Fever
;
Flaviviridae
;
Headache
;
Humans
;
Islands
;
Mortality
;
Nausea
;
Severe Dengue
;
South America
;
Tropical Climate
;
Virus Diseases
4.Seroprevalence of Dengue Virus Antibody in Korea
Ji Hyen LEE ; Han Wool KIM ; Kyung Hyo KIM
Pediatric Infection & Vaccine 2018;25(3):132-140
PURPOSE: The number of dengue fever cases is rising due to increasing overseas travel. Vaccination makes severe dengue fever in seronegative individuals after vaccination when they exposure to wild-type dengue virus. We investigated the seroepidemiology of the dengue virus for monitoring of Korean dengue virus immunity and establishing the prevention of dengue infection. METHODS: The study was based on 446 residual sera collected from 98 infants (2 months to 1 year old), 152 adolescents (13 to 19 years old), 90 adults (20 to 50 years old), and 106 elderly participants (more than 65 years old) for other studies. Antibody levels for dengue virus immunoglobulin G (IgG) in each age group were measured using an enzyme-linked immunosorbent assay (ELISA). For each dengue virus IgG positive or equivocal result, an IgG ELISA was performed for Japanese encephalitis virus. RESULTS: Of the 446 serum samples, only 1 (0.2%) adolescent had a positive result from the dengue IgG antibody test. In the dengue virus IgG antibody test, 14 (3.1%) samples showed equivocal results (10 adolescents and 4 elderly). In the 1 positive case of dengue virus IgG, the Japanese encephalitis IgG test was also positive. In the 14 equivocal cases of dengue virus IgG, there were 6 positive, 3 equivocal, and 5 negative of Japanese encephalitis IgG. CONCLUSIONS: The seroprevalence rate of dengue virus was very low in Koreans. This study provides important data for establishing the policy for preventive measures of dengue fever. It will be necessary to continuously monitor for dengue virus immunity.
Adolescent
;
Adult
;
Aged
;
Dengue Virus
;
Dengue
;
Encephalitis Virus, Japanese
;
Encephalitis, Japanese
;
Enzyme-Linked Immunosorbent Assay
;
Fever
;
Humans
;
Immunoglobulin G
;
Infant
;
Korea
;
Prevalence
;
Seroepidemiologic Studies
;
Severe Dengue
;
Vaccination
5.A Case of Dengue Fever Complicated by Rhabdomyolysis.
In Hae PARK ; Yeon A KIM ; So Youn SHIN ; Yoon Seon PARK ; Hee Jung YOON ; Chang Oh KIM ; Yoon Soo PARK ; Jun Yong CHOI ; Ae Jung HUH ; Young Goo SONG ; June Myung KIM
Infection and Chemotherapy 2005;37(4):234-236
The dengue virus causes dengue fever and dengue hemorrhagic fever. It is an arbovirus and is transmitted by mosquitoes, Aedes aegypti. Dengue fever is an acute viral illness characterized by fever, skin rash, severe headache, myalgia and arthralgia. Rabdomyolysis rarely occurs in dengue fever in contrast with other viral infections. In this case, the patient was suffering from fever and severe myalgia, especially both lower extremities, after traveling to Philippines. He was diagnosed with dengue fever complicated by rhabdomyolysis as a result of serologic test and bone scan. He completely recovered with conservative care and nutritional support. We experienced a case of dengue fever complicated by rhabdomyolysis, which was treated successfully with conservative care.
Aedes
;
Arboviruses
;
Arthralgia
;
Culicidae
;
Dengue Virus
;
Dengue*
;
Exanthema
;
Fever
;
Headache
;
Humans
;
Lower Extremity
;
Myalgia
;
Nutritional Support
;
Philippines
;
Rhabdomyolysis*
;
Serologic Tests
;
Severe Dengue
6.A Case of Dengue Shock Syndrome Imported from Myanmar.
Sung Young MOON ; Young Jun ROH ; Jong Hyek KIM ; Jee Yeon KIM ; Jin Gun KIM ; Joung Hun LEE ; Hyun Woo KIM ; Sang Min NAM
Infection and Chemotherapy 2003;35(4):230-234
Dengue fever/dengue shock syndrome is an acute febrile illness caused by a Flaviviridae virus. Dengue virus infection can cause a wide spectrum of illness, and disease is characterized by sudden onset of high fever, chill, severe headache, skin rash, general malaise and thrombocytopenia with hemoconcentration. Dengue fever is endemic in most tropical areas of world, including the Caribbean, Central and South America, Africa, and Southeast Asia. Tourists to these areas are liable to infection. We experienced a Korean female who returned to Korea from Myanmar in severely ill state. She was confirmed serologically to be inblieted with Dengue shock syndrome. In spite of intensive medical care, she died of Dengue shock syndrome. We emphasize that favorable prognosis depends mainly on the early recognition and treatment of shock.
Africa
;
Asia, Southeastern
;
Caribbean Region
;
Dengue Virus
;
Dengue*
;
Exanthema
;
Female
;
Fever
;
Flaviviridae
;
Headache
;
Humans
;
Korea
;
Myanmar*
;
Prognosis
;
Severe Dengue*
;
Shock
;
South America
;
Thrombocytopenia
7.A Case of Dengue Fever Complicated by Rhabdomyolysis.
In Hae PARK ; Yeon A KIM ; So Youn SHIN ; Yoon Seon PARK ; Hee Jung YOON ; Chang Oh KIM ; Yoon Soo PARK ; Jun Yong CHOI ; Ae Jung HUH ; Young Goo SONG ; June Myung KIM
Infection and Chemotherapy 2005;37(4):234-236
The dengue virus causes dengue fever and dengue hemorrhagic fever. It is an arbovirus and is transmitted by mosquitoes, Aedes aegypti. Dengue fever is an acute viral illness characterized by fever, skin rash, severe headache, myalgia and arthralgia. Rabdomyolysis rarely occurs in dengue fever in contrast with other viral infections. In this case, the patient was suffering from fever and severe myalgia, especially both lower extremities, after traveling to Philippines. He was diagnosed with dengue fever complicated by rhabdomyolysis as a result of serologic test and bone scan. He completely recovered with conservative care and nutritional support. We experienced a case of dengue fever complicated by rhabdomyolysis, which was treated successfully with conservative care.
Aedes
;
Arboviruses
;
Arthralgia
;
Culicidae
;
Dengue Virus
;
Dengue*
;
Exanthema
;
Fever
;
Headache
;
Humans
;
Lower Extremity
;
Myalgia
;
Nutritional Support
;
Philippines
;
Rhabdomyolysis*
;
Serologic Tests
;
Severe Dengue
8.A Case of Dengue Shock Syndrome Imported from Myanmar.
Sung Young MOON ; Young Jun ROH ; Jong Hyek KIM ; Jee Yeon KIM ; Jin Gun KIM ; Joung Hun LEE ; Hyun Woo KIM ; Sang Min NAM
Infection and Chemotherapy 2003;35(4):230-234
Dengue fever/dengue shock syndrome is an acute febrile illness caused by a Flaviviridae virus. Dengue virus infection can cause a wide spectrum of illness, and disease is characterized by sudden onset of high fever, chill, severe headache, skin rash, general malaise and thrombocytopenia with hemoconcentration. Dengue fever is endemic in most tropical areas of world, including the Caribbean, Central and South America, Africa, and Southeast Asia. Tourists to these areas are liable to infection. We experienced a Korean female who returned to Korea from Myanmar in severely ill state. She was confirmed serologically to be inblieted with Dengue shock syndrome. In spite of intensive medical care, she died of Dengue shock syndrome. We emphasize that favorable prognosis depends mainly on the early recognition and treatment of shock.
Africa
;
Asia, Southeastern
;
Caribbean Region
;
Dengue Virus
;
Dengue*
;
Exanthema
;
Female
;
Fever
;
Flaviviridae
;
Headache
;
Humans
;
Korea
;
Myanmar*
;
Prognosis
;
Severe Dengue*
;
Shock
;
South America
;
Thrombocytopenia
9.Septic Shock as a Differential Diagnosis of Severe Dengue Fever in a Child in Malaysia - a Case Report
Malaysian Journal of Medicine and Health Sciences 2019;15(2):154-156
Dengue fever infection is common in many parts of the world and may result in serious complications such as dengue haemorrhagic fever, dengue shock syndrome, pleural effusion, pericardial effusion and multi-organ failure if not diagnosed early or treated adequately. This is more so in the so called susceptible group that includes children, pregnant mother, elderly patients, patients with heart, liver or kidney co-morbidity, obese patients as well as immunocompromised patient such as those with transplanted organs or human immune-deficiency infection. However in certain cases, severe dengue fever may mimic the presentation of septic shock which needs urgent and decisive management actions to be taken. This case report will look at a 7-year-old child who survived despite developing septic shock which was thought to be initially dengue fever with warning signs. Early referral and aggressive treatment in hospital prevented a direr consequence for this child.
Dengue fever
10.A case of imported dengue fever.
Myung Soo KIM ; Ja Kyung KIM ; Young Keun KIM ; Kkot Sil LEE ; Joon Sup YEOM ; Aejung HUH ; Kyung Hee CHANG ; Young Goo SONG ; June Myung KIM
Korean Journal of Medicine 2002;62(5):548-551
Dengue fever (DF) is an acute febrile viral disease frequently presenting with headache, bone or joint and muscular pain, rash and leukopenia. Dengue hemorrhagic fever (DHF) is characterized by four major clinical manifestations: high fever, hemorrhagic phenomena, often with hepatomegaly and in severe cases, signs of circulatory failure. Such patients may develop hypovolemic shock resulting from plasma leakage. This is called dengue shock syndrome (DSS) and can be fatal. The disease is one of the leading causes of hospitalization and death in children in several Asian, central and south American and African countries. Dengue fever and Dengue hemorrhagic fever have steadily increased in both incidence and distribution over the past 40 years. With an increased air travel, more travelers to the tropics and subtropics are returning within the incubation period of acute febrile infection. We experienced a Korean engineer with complaints of fever, chill, headache, nausea and myalgia after return from Malaysia and confirmed as dengue fever.
Asian Continental Ancestry Group
;
Child
;
Dengue*
;
Exanthema
;
Fever
;
Headache
;
Hepatomegaly
;
Hospitalization
;
Humans
;
Incidence
;
Joints
;
Leukopenia
;
Malaysia
;
Myalgia
;
Nausea
;
Plasma
;
Severe Dengue
;
Shock
;
Virus Diseases