OBJECTIVE:To observe therapeutic efficacy and safety of prednisone acetate combined with leflunomide in the treatment of IgA nephropathy. METHODS:80 patients with IgA nephropathy were randomly divided into observation group and control group,with 40 cases in each group. Control group was given prednisone acetate 1.0 mg/kg,qd,6 weeks later,decreasing gradually,decreasing to 0.5 mg/kg in 12th week;observation group was additionally given leflunomide 50 mg,qd,3 days later de-creasing to 20 mg. Both groups were given 3 months of treatment. Clinical efficacy,24 h urinary protein quantification,Scr and BUN levels were observed in 2 groups after treatment,and ADR were recorded during treatment. RESULTS:Total effective rate of observation group(95.0%)was significantly higher than that of control group(75.0%),with statistical significance(P<0.05). Af-ter treatment,24 h urinary protein quantification,Scr and BUN levels of observation group were significantly lower than those of control group,with statistical significance(P<0.05). The incidence of ADR in observation group(0)was significantly lower than in control group(7.5%),with statistical significance(P<0.05). CONCLUSIONS:Prednisone acetate combined with leflunomide has significant effect on IgA nephropathy,and will not increase the occurrence of ADR.

Objective To investigate the clinical efficacy of hydrogen-rich water (HRW) combined with oxycodone hydrochloride controlled-release tablets (OHCT) in the treatment of malignant neuropathic pain (MNP) patients.Methods Eighty MNP patients were randomly divided into two groups:OHCT group (group A,n =40) and HRW combined OHCT group (group B,n =40).The visual analog scale (VAS) score,frequency of pain outbreaks,pain relief rate,average dose of OHCT per day,and adverse reactions were observed.Results The VAS scores and frequency of pain outbreaks in groups A and B were significantly reduced after treatment (P ＜0.05).Compared to group A,the VAS scores,pain relief rate,outbreak pain and average dose of OHCT per day in group B were significantly improved after 14 and 28 days of treatment (P ＜ 0.05),and the adverse reactions,such as constipation,nausea and vomiting,in group B were significantly less than those in group A (P ＜ 0.05).Conclusions HRW combined with OHCT can effectively improve the MNP,and reduce average dose of OHCT per day and adverse reactions.

Objective: To explore the relation between self-esteem and mental health of normal college students.Methods: 386 normal college students finished the Self-esteem Scale(SES),Symptom Checklist 90(SCL-90),Self Consistency and Congruence Scale(SCCS) and College students' Behavioral Inhibition Scale(CBIS).Results: There was close relationship between self-esteem and mental health;those students with high self-esteem had more self consistency and congruence,less symptomatic and behavior inhibition.Conclusion: It indicates that self-esteem can effectively predict mental health for normal college students.

Objective: Self-enhancement is a kind of motive that urges people to attend exclusively to the positive aspects of himself,it is so intense that individuals even tend to distort the threatening information to some degree so that they can maintain a positive self-view. This research is to investigate the pattern of self-enhancement of Chinese people. Methods: Self-enhancement was measured by requiring participants to make self attribution as well as other attribution of their success and failure on eight factors. Results: There existed strong self-enhancement motive in Chinese individuals. Specifically,Chinese undergraduates attribute their success to inner factors such as personality and effort. This trends also evident in the conditions in which participants were asked to speculate the attribute pattern of other people like his/her mother on their own success and failure. Conclusion: Chinese undergraduates tend to enhance the self-image in other people's eyes.

Objective: To investigate the rural middle school students' mental health and explore its determinants. Methods: 989 rural middle school students in Jiangxi province were investigated with SCL-90, Social Support Rating Scale and the Chinese versions of EMBU. Results: The major problem of mental health were interpersonal sensitivity, obsessive-compulsive, depression, hostility and paranoid ideation. There was remarkable difference between boys and girls, senior and junior high school students. Multiple regression analysis indicated that the major determinants of the rural middle school students' mental health were subjective social support, usage of social support, father's and mother's rejection and denying, father's over-protection, mother's punishment and rigidity, different sex, grades and only children or non-only children. Conclusion: The students in rural middle school, especially in senior high school, had severe mental health problems, social support and parental rearing patterns have a significant influence on mental health.

Objective To investigate the characteristics in sleep architecture of sub-healthy people with in-somnia,and to study the relationship between the sleep architecture and the degree of insomnia.Methods Sleep ar-chitecmre and Pittsburg sleep quality index(PSQI)value and PSQI scale were detected respectively.Results Sleep architecture of 46 subjects was abnormal-including shortened total-sleep-time(26.1%),excessive superficial-sleep stage(100%).inadequate deep-sleep stage(87.0%),insufficient rapid eye movement sleep(REM) (60.9%),longer sleep latency(65.2%)-more wakening times(47.8%)and longer wakeful time(43.5%).PSQI value of each insomniac exceeded 7,and the valtie of most objects was between 12 and 16(73.9%).The in-gredients of sleep architecture were not significantly correlated with the values of PSQI (P>0.05).Conclusion The sleep architecture of sub-healthy people with insomnia is mainly characterized with difficulty in falling asleep,light sleep and festless sleep,but the characteristics of sleep architecture is not inevitablly related with the degree of insomnia.

Objective:To study and design measurement scale which can judge and survey sub-health state and itscharacteristic of TCM syndrome.Methods:Making use of methods of scale technique,literature research,expertise consultation et al,based on TCM theory,via conceptualization and operation of sub-health and TCM syndrome,forming structure and type of scale,establishing item pool and results,and then through item selection,assessment of validity and reliability of pre-investigation,making the measurement scale.Results:The scale is made up of 4 parts:body function state,psychological function state,social function state and particular state of TCM.The 4 parts are divided into 15 sorts,including 120 items.Conclusion:The scale contributes much to the diagnosis of sub-health state and the clari cation of clinical manifestations,features,distributions of TCM syndrome of public of sub-health,which is one of the most important methods for investigating TCM syndrome of sub-health state.

Objective To study the effect of dexmedetomidine in the functional endoscopic sinus surgery (FESS) on the recovery period of general anesthesia. Methods Fifteen min before the end of surgery, 40 FESS patients were treated with intravenous infusion of dexmedetomidine at 0.6μg/kg. The occurrence of cough response, degree of pain and agitation in patients were observed. Result The response score of choking cough of the patients with intravenous infusion of dexmedetomiindine was (1.2 ± 0.5), the score of VSA was (1.9 ± 0.5), and the degree of agitation was (1.2 ± 0.4). Conclusion For those undergoing FESS, postoperative use of dexmedetomidine 15 min before the end of surgery, can not only have an effective effect for reducing the incidence of choking cough and agitation and but also decrease the pain degree so that the patients can live through the general anesthesia recovery period.

1 1 patients with moderate or severe crowding in the anterior arch were treated with 4 premolar extraction.After canine distaliza-tion first approach,the teeth were aligned and leveled.The results of the study suggest that,with strict implementation of indication,this method may be a viable treatment for the moderate or severe crowding anterior.