Objective To explore the application effect of the surgical concept of accelerated rehabilitation in perioperative care of total laryngectomy.Methods Totally 56 patients with laryngocarcinoma were categorized to the enhanced recovery after surgery (ERAS) group (n=25) and the control group (n=31). Patients in two groups both were given routine care, while patients in ERAS group also were given other procedures such as shortening fasting period, inserting gastric tube, early activity and cultivating patients' self-care ability, etc. Complications, total hospitalization fee, hospitalization time after surgery, satisfaction of patients and self-care ability of patients between two groups were compared.Results There was 1 case of pharyngeal fistula in ERAS group and 2 cases in the control group, there were 4 cases of pulmonary infection in the control group. In ERAS group, the hospitalization time after surgery (13.76±1.48) d and total hospitalization fee (37467±2232) yuan were all lower than those of the control group (t=8.861, 5.980;P<0.01). The satisfaction degree of patients in ERAS group was 88.00%, in the control group was 61.29% (χ2=5.034, P<0.05). The score of self-care ability of patients in ERAS group was (140.10±4.63), which was higher than that of the control group (t=40.594,P<0.01).Conclusions Accelerated rehabilitation can promote the postoperative recovery of patients with total laryngectomy, reduce total hospitalization fee, improve patients' satisfaction, increase patients' self-care abilities and improve patients' quality of life.