In recent years,we have progressed in the treatment of coronary heart disease by a large margin,which improved the prognostic condition of coronary heart disease patients,conspicuously.Whereas,we have still harbored discordant reservations about what fuels in the theraputic stragety of the left main and/or three vessel disease which causes acute myocardial infarction and the sudden cardiac death,for the time being,internationally.EuroSCORE and SYNTAX Score are both widely accepted in probing in the theraputic stragetic credits,internationally.Hence,we are about to review the twin credits system on the optional directive meaning of the strategy of myocardial revasscularization in the left main and/or three vessel patients.

Chronic inflammation is proved to play an important role in promoting carcinogenesis.Many factors in inflammatory microenvironment,such as inflammatory immune cells,pro-inflammatory cytokines,inflammatory mediators,and aberrantly activated transcription factors of pro-inflammatory pathway (NF-κB,STAT3),have been found to provide a microenvironment for lung neoplastic processes,and promote the lung carcinogenesis.On the other hand,many anti-inflammatory agents have been shown having inhibitory effects on lung tumorigenicity.With further understanding of the molecular links between inflammation and lung tumorigenesis,anti-inflammation would provide alternative strategies for prevention and therapy of lung cancer.

Eukaryotic cells maintain cellular homeostasis by regulating the process of protein degradation and organelle turnover.Autophagy is a ubiquitin-like degradation process,and plays an essential role in cellular development,differentiation,and elimination of damaged organelles and protein.Previous studies mostly focused autophagy on tumor and neurodegenerative diseases,whereas studies about autophagy and energy remain not clear.Since 2009,an increasing number of studies have showed light on the importance of autophagy in regulating lipid metabolism.The review focuses on the relationship between autophagy and differentiation of adipocytes,lipogenesis,and lipolysis.

OBJECTIVE:To optimize the formulation technology of paeonol-?-cyclodextrin inclusion compound. METHODS: The formulation technology of paeonol-?-cyclodextrin inclusion compound was optimized by performing orthogonal experiment with the amount of ?-cyclodextrin,the solid-liquid ratio (ratio of ?-cyclodextrin to paeonol alcohol solution),the concentration of the envelop liquid (alcohol) as factors and the ultrasonic time was studied by single factor test and with the utilization ratio and entrapment efficiency of paeonol as indexes for evaluation. Meanwhile,a verification test was performed. RESULTS: The optimal formulation technology was as follows: the amount of ?-cyclodextrin was 8 g;the solid-liquid ratio was 1∶3;the concentration of the alcohol was 40% and the ultrasounding time was 40 min. The verification test revealed that the labeled contents were about 90% for all samples (4 batches). CONCLUSION: The optimized formulation technology is simple and reasonable,and it is applicable for the preparation of paeonol-?-cyclodextrin inclusion compound.

Objective To observe the changes of serum leptin(LP) levels and serum tumor necrosis tactor-alpha(TNF?) concentrations and to explore the relationships with fasting serum insulin levels and congestive heart failure(CHF).Methods Serum leptin and inslin concentrations were measured by radioimmunoassay and tumor necrosis factor-alpha by ELISA.Body mass index(BMI),mean arterial blood pressure(MBP),fasting serum insulin(FINS),LP and TNF-alpha levels were determined in 40 patients with CHF and in 20 healthy controls matched for gender,age,BMI and MBP.The correlations between leptin and other parameters were analyzed.Results ⑴The fasting serum LP and FINS concentrations of patients with NYHA grade Ⅲ and NYHA grade Ⅳ were significantly lower as compared with the controls(P0 05).⑵The TNF alpha was higher in heart failure patients that in healthy controls(P

OBJECTIVE:To build up a method for determining the concentration of zaleplon in human plasma by HPLC. METHODS:The Kromasil-C 8 column was used and mobile phase consisted of methanol-water(65∶35);the flow rate was1.0ml/min,fluorescence excitation wave-length was233nm;fluorescence emission wave-length was460nm.RESULTS:The calibration curve revealed linearity in the concentration range of0.42～73.92ng/ml(r=0.9999)with a regressive equation of Y=1.870?147.The average recovery was99.47%.The with-day and between-day RSDs were4.9%and4.73%respec?tively.CONCLUSION:The method is accurate,reliable and highly sensitive so it can be used in study of pharmacokinetics of zaleplon.

Objective To establish a method of testing lysophosphatidic acid (LPA) by enzymatic cycling. Methods The detection system was developed on the principle of enzymatic cycling method and characteristic of LPA. The methodology was evaluated and the content of LPA was tested in 20 samples of plasma with ovarian carcinoma. Results The linearity was 18.6?mol/L and the detection limit was 0.03?mol/L. The within-run and between-run coefficient of variations were 5.3% and 7.4%, respectively. The recovery was 100.7% and there was a significant correlation with the liquid chromatography method(Y=0.953X+0.51). The reagent system was stable and different concentrations of bilirubin, hemoglobin, triglyceride, glucose, urea and ascorbate did not affect the measurement for the assay. The content of LPA in 20 samples of plasma with ovarian carcinoma was significantly higher than that in control group (P

OBJECTIVE:To investigate the general patterns and characteristics of the adverse drug reactions(ADR) induced by interferon and to provide guidance for its rational use in the clinic.METHODS:A total of 64 ADR cases induced by interferon reported in the domestic medical journals during the period 2000～2006 were collected and analyzed statistically. RESULTS:The ADR induced by interferon was more often seen in patients aged 30～39 years old(35.94%),with male showing higher proportion than female(68.75% vs. 31.25%).ADR more often occurred after multiple dosing and were characteriz-ed predominantly by allergic reactions of immune system in which multiple organs or systems may be involved.CONCLUSION:Interferon should be used rationally based on indications of medication and be closely monitored to prevent and reduce the occurrence of ADR.

Effects of epidural block on stress response during eardiopulmonary bypass were studied. Twenty patients, undergoing open heart surgery with cardiopulmonary bypass, were randomly divided into two groups:the control group with intravenous high-dose fentanyl and enflurane inhalation (1%-1.5%);the tested group with epidural block and enflurane inhalation (0.5%-1%). The plasma norepinephine (NE) and epinephrine (E) concentrations were higher in group control than those in tested group during and after CPB,even at the end of operation (P

0 05); when concentration of H.pylori ≥1 6?10 8 CFU/L,apoptosis rate increased in a concentration-dependent manner ( P