OBJECTIVE:To evaluate the cost-effectiveness of different slow-release isosorbide mononitrate preparations in the treatment of coronary heart disease.METHODS:The random open study,three factors crossover trial and own control clinical test were conducted on3different Isosorbide mononitrate preparations.Then the curative effects of each were observed and the cost-effectiveness analyses were conducted.RESULTS:For the three kinds(A,B and C)of slow-release isosorbide mononitrate capsule,their total effective rates were87.9%,69.7%and57.6%respectively;the average daily medical expenses of which were10.25,15.14and14.04respectively;their cost-effectiveness ratio were69.97,130.33and146.25yuan respectively.CONCLUSION:The cost-effectiveness of the slow-release isosorbide mononitrate preparations is superior to the control medicines in the treatment of coronary heart disease.