Objective To investigate the clinical and imaging characteristics of tumor like inflammatory demyelinating disease of CNS, We have analyzed the reason of misdiagnosis, and summed up the main point of differential diagnosis.Methods We have analyzed 14 cases which were confirmed as demyelinating disease in pathology after the operation, and all the clinical and image data were included.Results CNS inflammatory demyelinating disease could present edema and mass effect by CT or MRI, there was ring potentialization after enhancement, it was difficulty to distinguish from CNS demyelinating disease. All the 14 patients were misdiagnosis as CNS tumor before the operation.Conclusion CNS inflammatory demyelinating disease could have some atypical representation on CT or MRI image, they were made easily the misdiagnosis. We should get the differential diagnosis by many ways including clinical manifestation, course, laboratory examination and imaging characteristics.

Objective:To investigate the value of NMO-IgG in diagnosis of neuromyelitis optica(NMO).Methods:A total of 120 patients with NMO,including high-risk NMO(HR-NMO),multiple sclerosis(MS),and other neurological diseases were enrolled in the study.The titres of serum NMO-IgG in all patients’ were detected by indirect immunofluorence.Results:The sensitivity and specificity of NMO-IgG were 67%,92% respectively in diagnosis of NMO.There were significantly differences in serum NOM-IgG posieivity among patients with NMO and MS who experienced severe optical neuritis,transverse myelitis,spinal-cord lesion beyond 3 segments as well as the patients with normal MRI scan in brain brain normal in MRI scan,serum and accompanied with other immunological disorders(P

0. 05), TAE of flexors in patients were lower than those in the healthysubjects(P 0. 05 ). F/E in patients were greater than those in healthy subjects(P

Objective To analyze clinical characteristics of 8 cases of MELAS syndrome that misdiagnosed as herpes simplex virus encephalitis(HSE).Methods The clinical data of 8 cases of MELAS syndrome that misdiagnosed as HSE were reviewed retrospectively.Results The main manifestations of 8 cases were repeated fever,progressive mental impairment,seizures,headache,descent of eyesight and hearing,weakness of extremities.Fever was the common symptom in the 8 cases.Exercise tolerance dose of serum lactic acid levels studied in 8 cases were obviously abnormal.Imaging examinations showed laminar necrosis or atrophy in brain lobes and basal ganglia areas.Electroencephalogram(EEG) mainly showed diffused slow waves,1 patient displayed myogenic injury in electromyogram(EMG).Muscle biopsy showed red ragged fibers and abnormal mitochondria in all cases.Conclusions The clinical manifestations of MELAS syndrome are similar to HSE,but EEG and imaging results are obviously different from HSE.Exercise tolerance dose of serum lactic acid and muscle biopsy are important for diagnose of MELAS syndrome.

Objective To study the clinical characteristics and differential diagnosis of Miller-Fisher syndrome (MFS) and Bickerstaff's brainstem encephalitis (BBE).Methods The clinical data of 12 patients with diagnosis of MFS and 15 patients with diagnosis of BBE were analyzed retrospectively.Results In MFS group, the patients showed diplopia (12 cases), loss of pupillary light reflex (3 cases), peripheral facial paralysis (7 cases), hydroposia bucking (1 case), weakness of limbs (6 cases), sensory disability (4 cases) and ataxia (10 cases). In BBE group, the patients presented with diplopia (11 cases), central facial palsy (4 cases), tinnitus (4 cases), hydroposia bucking (6 cases), weakness of limbs (10 cases), sensory disability (2 cases), ataxia (10 cases), somnolence or coma (5 cases) and positive Babinski's sign (9 cases). CSF examination showed elevation of protein in 10 patients from BBE group and 10 patients from MSF group, however, leucocytosis was found in 6 cases from BBE group and 2 cases from MSF group. There were 4 patients of MFS and 1 patient of BBE with abnormal results of electromyogram (EMG) examination. 6 patients in BBE group had abnormal results of CT or MRI examinations, and the lesions mainly located in brainstem, thalamus and so on. Both groups had good prognosis after therapies. Conclusions MFS and BBE have similar and overlapped clinical characteristics. This indicates that these two diseases are closely related and may form a continuous spectrum. The main identifications of BBE are conscious disturbance, positive reflex of Babinski's sign and abnormal imaging results in some patients.

To ascertain the change of trunk muscle strength and lumbar curvature and cross sectional area of M. sacrospinalis in low back pain caused by military training, the indexes of trunk muscle strength (PT/BW, TAE, F/E) were measured in patients with low back pain and healthy subjects with CYBEX 6000 isokinetic testing system. The lumbar curvature was measured in lumbar X ray films on the lateral projection in standing position, and the cross sectional area of sacrospinalis was measured by ultrasonography. All of the indexes were compared between the two groups.The results showed PT/BW of flexors was not significantly different between the patients and healthy subjects, TAE of flexors in patients was lower than that of healthy subjects ( P

To elucidate the change in trunk muscle performance in patients with low back pain caused by military training. The indices of trunk muscle strength (PT/BW, TAE, F/E, ER), the cross-sectional area of sacrospinalis, the amplitude and the duration of EMG, and the lumbar curvature were measured in recruits with low back pain after military training (n=40)and healthy subjects(n=40).All of the indices were compared between two groups. It was found that except PT/BW and ER of flexors and cross-sectional area of sacrospinalis, there were significant differences between other indices of the patients compared with healthy subjects(P

Objective To analyse the clinical features and prognosis of multiple sclerosis (MS). Methods Clinical data of 117 patients with MS were analyzed retrospectively. The clinical and imaging characters in types of optico-spinal(OSMS) and conventional MS(CMS) were compared.Results Among the 117 MS patients, 42 cases(35.9%) were OSMS. 75 cases(64.1%) were CMS. About the clinical manifertation, the incedence of extremital weakness(88.1%), anesthesia(85.7%),abnormal sensation(57.1%), vision(76.2%), urination disorder (73.8%) in OSMS patients were significantly higher than those in CMS patients(70.7%,56.0%,20.0%,45.3% and 26.7%)(allP

Objective To research the risk factors of youth carotid artery thrombosis,to provide some basis for its clinical prevention and treatment.Methods Twenty-three patients of youth carotid artery thrombosis (experimental group),40 patients without youth carotid artery thrombosis (control group) were selected,and we collected the data including age,sex,body mass index,smoking,drinking history,hypertension,neck trauma,C reactive protein,total cholesterol,triglyceride,LDL-C,HDL-C,uric acid,syphilis antibody,HIV antibody,then we did statistical analysis.Results The basic situation of the two groups:there were statistical differences in sex and BMI (P ＜0.05);past medical history and personal history of patients in two groups:diabetes,high blood pressure,smoking,drinking,history of neck injury,syphilis antibody had statistical differences (P＜0.05);biochemical indicators of two groups of patients:there were statistical differences in HDL and uric acid (P＜0.05);multi factor analysis:risk factors were hypertension (0R=6.43),smoking (OR=4.63) and neck injury history (OR=3.13).Conclusions The risk factors of youth carotid artery thrombosis are hypertension,smoking,neck injury history,the prevention and cure of hypertension,smoking and neck injury should be strengthened,so as to reduce the incidence of carotid artery thrombosis.

Objective To explore the effect of FESS on nasal resonance characteristics in patient with chronic sinusitis .Methods Detected 50 cases of adult patients with type Ⅱ chronic sinusitis ,and collected the date about the application of multi-channel voice analysis system that tested the pronunciation /i/before and three months af-ter FESS spectrum - energy distribution while compared with 50 normal subjects .Results Patients with type Ⅱchronic sinusitis before surgery compared with normal subjects ,the head of the low -frequency energy was higher , high-frequency was lower ,the difference was statistically significant (P<0 .001) .Voice energy distribution after three months compared with preoperative ,the head of the high-frequency resonance energy improved than preop-erative ,but still relatively low compared with the normal ,the difference was statistically significant (P<0 .05) . While the mouth ,chest and throat in addition to oral FR3 ,FR4 ,postoperative throat FR4 and preoperative chest FR4 ,other frequency -energy compared with normal subjects no significant change was not statistically significant (P>0 .05) .Conclusion For patients with chronic sinusitis ,low -frequency of the voice of nasal resonance de-creased ,and high-frequency increased after FESS .