Objective To observe the effect of calcitonin on senile osteoporosis. Methods Eighty-six osteoporotic patients diagnosed by double-energy X-ray absorptiometry and manifested clinical symptoms and with spinal bone mineral density (BMD) 2 or more were divided into two groups: 46 patients in the observed group were administered 100 IU calcitonin once a day for three days, and changed to 50IU calcitonin once every other day for one month; repeat the administeration method after one month rest and plus oral calcium carbonate vitamin D 600 mg every day for a period of 6 months; another 40 patients in the control group only took calcium carbonate vitamin D 600 mg every day for 6 months. The BMD of L1-4 and hips was examined before and after treatment. Results Bone pain relieving was more obviously in the observed group than that in the control group. BMD of the lumbar spine in the observed group showed remarkable change after treatment(P

OBJECTIVETo determine the influence of androgen deprivation therapy (ADT) on bone mineral density (BMD) in men with prostate cancer.

METHODSForty-nine men with prostate cancer underwent BMD determination and then were classified into two groups: non-ADT group (21 cases), who were about to receive ADT, and ADT group (28 cases), who had received ADT for more than 1 year. BMD was determined by dual energy X-ray absorptiometry (DEXA) in the lumbar spine (L2-4) and femoral neck in all the patients. The Age-Matched Z scores were used as the reference standard for controlling the difference of age, sex and weight.

RESULTSThirteen (62%) of the non-ADT group and 23 (82%) of the ADT group fulfilled the BMD criteria for osteopenia or osteoporosis. Z scores for the Age-Matched control in the lumbar spine and femoral neck were -(0.9 +/- 0.7) and -(0.6 +/- 0.5) in the non-ADT group, and -(1.8 +/- 1.1) and -(1.6 +/- 1.0) in the ADT group, respectively (P<0.01). The men of the ADT group had significantly lower BMD in the lumbar spine and femoral neck than those of the non-ADT group.

CONCLUSIONPre-existing osteopenia and osteoporosis are common in men with prostate cancer before ADT. ADT is significantly associated with the loss of BMD and the evaluation of BMD is necessary before ADT for men with prostate cancer.

Absorptiometry, Photon ; Aged ; Aged, 80 and over ; Androgen Antagonists ; therapeutic use ; Bone Density ; Humans ; Male ; Middle Aged ; Orchiectomy ; Osteoporosis ; complications ; physiopathology ; Prostatic Neoplasms ; complications ; physiopathology ; surgery