Objective To study the interactive mechanism of information retrieval behaviors and innovative behaviors in members of scientific project team engaged in scientific research.Methods The information retrieval behaviors and innovative behaviors in 218 members of 36 scientific project teams were investigated using self-designed information retrieval behavior and innovative behavior scale.The interactive mechanism of information retrieval behaviors and in-novative behaviors was analyzed by descriptive analysis, t test, and F test, respectively.Results The information retrieval behavior dimensions in members of scientific project team engaged in scientific research interacted with their innovative behaviors, innovative awareness, innovative nature, and innovative environment.The effect of in-formation assessment on innovative behaviors was most significant.Innovative behaviors were closely related with information retrieval behaviors.The effect of innovative nature on information retrieval behaviors was also most sig-nificant.Conclusion The information retrieval ability, information literacy, innovative nature, innovative aware-ness, and innovative ability should be strengthened in members engaged in scientific research.

The problems in digitalization of ancient medical documents were described according to its status quo analysis, with certain measures for their solution proposed in order tospeed up the digitalization of ancient medical documents, improve the use of ancient medical documents, and promote the rapid development of medical and health cause.

The reform of medical informatics education in big data environment was elaborated in terms of its new target , new contents , new principles and new challenges , and the development of medical informatics education in big data environment was dealt with in aspects of its resources, teaching mode, educational decision-making and training program in order to evoke considerations over medical informatics in the big data time.

Objective To make a comparative study of the two intelligent Pubmed-based retrieval tools,Gopubmed and Pubmedpro.Methods We took lung cancer literatures as an example in this article,probed into the difference between these two tools in several aspects including retrieval tech niques,browse,boolean retrieval,statistical analysis items,statistical analysis accuracy,access and retrieval speed.Results Gopubmed and Pubmedpro shared the similar retrieval techniques,but the latter had more browse,boolean retrieval and statistical analysis functions,and had better analysis accuracy,easier access and faster retrieval speed.Conclusion Pubmedpro had advantages over Gopubmed in general.

ObjectiveTo investigate the management of myonephropathic-metabolic syndrome (MNMS) after acute arterial occlusion. Methods17 cases of MNMS caused by acute arterial occlusion were restrospectively reviewed. Results5 cases were cured, 6 cases died of sudden cardiac arrest induced by hyperkalemia, and another 6 cases died of multiple organ dysfunction syndrome (MODS) complicated by acute renal failure. The total mortality rate was 71% and the amputation rate was 41%.ConclusionEarly revascularization should be performed in acute arterial occlusion. In patients with compartment syndrome, fasciotomy should be performed as soon as possible. Early amputation of gangrene limb is very important to prevent MNMS. Early and effective fluid resuscitation and alkalinization is the key point to prevent ARF, early hemodialysis for ARF is very important in treating MNMS.

Objective:To investigate the correlation of FAT10 expression with the malignant characteristics of hepatocellular car-cinoma (HCC), and to explore the effect of FAT10 on RhoA and cytoskeleton of HCC. Methods: Immunohistochemistry (IHC) was used to detect the FAT10 expression level of 108 HCC patients, and the correlation between the expression of FAT10 and the malignant characteristics of HCC patients was analyzed. We transiently transfected plasmids with overexpressed FAT10 using 7721 and HepG2 cells or interfered with FAT10 expression using siRNA in Huh7 and LM3 cells. Active-RhoA, total-RhoA, and ROCK protein expres-sion levels were detected by Western blot analysis after overexpression or interference. We also used immunofluorescence to detect changes in the cytoskeleton protein F-actin after FAT10 overexpression in 7721 cells. Results:Correlation analysis showed that both ac-tive-RhoA and FAT10 expression levels were significantly correlated with clinical malignant characteristics by using IHC (RhoA:me-tastasis, P=0.036 and recurrence, P=0.026;FAT10:metastasis, P=0.031 and recurrence P=0.004). In addition, active-RhoA expression level was correlated with FAT10 (P=0.000). Survival analysis showed that the prognoses of low-expression active RhoA (P=0.019) or FAT10 (P=0.026) groups were significantly better than those of the high-expression groups. Western blot analysis showed that FAT10 increased the expression of active-RhoA and ROCK. However, the expression of active-RhoA and ROCK decreased after FAT10 inter-ference. F-actin expression increased in the 7721 cells with overexpressed FAT10 (all P<0.01). Moreover, FAT10 facilitated F-actin ag-gregation on cell membrane and changes in F-actin. Conclusion:FAT10 is correlated with the malignant characteristics of HCC and may promote changes in HCC cytoskeleton induced by active-RhoA.

Utilization and satisfactiontheory in diffusion science and the advantages of using micro-blog in study were described .Autilization and satisfactionmodel of micro-blog used in study by medical undergraduates born after 1990s was established with measures proposed for improving their study ability using micro-blog.

OBJECTIVE To investigate the epidemic situation of vertical dissemination of the Escherichia coli(ECO) and Klebsiella pneumoniae(KPN) isolates producing extended-spectrum beta-lactamases in the hospital.METHODS The fingerprints of the isolates were obtained by pulsed-field-gel-electrophoresis(PFGE),and were analyzed with software Quantity One.RESULTS The similarity of 10 isolates and 7 isolates among the 21 ECO(isolates) from ICU was more than 90%,and 100%,respectively;the similarity of 3 KPN isolates was 100%.The similarity of 9 isolates among the 20 ECO(isolates) was more than 90% and the similarity of 4 isolates among the 6 KPN isolates was more than 90% in the neurosurgery ward.The similar coefficients of 3 isolates and 2(isolates)(among) the 10 ECO isolates from the ward for cadre were more than 90% and 100%,(respectively.) The similar(coefficients) of 2 isolates among the 7 ECO isolates from the gastroenterology ward and 2(isolates)(among) the 18 ECO isolates from the respiratory ward were more than 90%.The isolates whose similarity was more than 90% were also found in other wards.CONCLUSIONS There are vertical disseminations of single clone of ESBL-producing organisms in several wards,especially in the ICU.It is necessary to strengthen the management of(infection)-control.

Objective To probe into the status and development trend of ebola,so as to provide reference for further research.Methods This paper took the ebola literature as the object of study,took GoPubMed as the retrieval and statistical tool,and conducted information analysis of the subjects,time,sources,distribution,authors and literature development trends of ebola research.Results The main subjects of ebola literature involved ebola virus and hemorrhagic fever,ebola.There has been a sharp increase on the literature number of ebola in the recent two years,particularly in 2014.The majority of literature came from the United States,and Britain ranked the second.The sources of ebola literature were mainly the SCI journals published in the United States and British.Conclusions GoPubMed can provide a vivid picture of the current situation and development trend of ebola research.Further improvements are needed both in the quality and quantity of ebola research in China.

Digitalization of ancient medical documents has become an important platform for the development and protection of medical literature and digitalization of ancient medical documents based on ancient medical documents themselves will lead to a series of intellectual property rights. After the relationship between ancient medical docu-ments and protection of intellectual property rights was analyzed, the major intellectual property rights involved in current digitalization of ancient medical documents were pointed out with their solutions elaborated from the reasona-bleness, rationality, legality and normality.