Introduction: Rhabdomyosarcoma (RMS) is the major soft tissue sarcoma in childhood, correlated with high morbidity and mortality. We defined clinico-epidemiological profiles and prognoses on pediatric RMS patients in Indonesia. Methods: This study was conducted retrospectively by examining all medical records of pediatric RMS patients in Dr. Sardjito Hospital, Yogyakarta, Indonesia, for 5 years from 2011 until 2016. Results: There were 21 RMS patients in this study. The median age of our subjects was 6 years and predominantly under 10 years old (71.4%). There was a greater tendency for the disease in males, with a male to female ratio of 2 : 1. The head and neck region was the primary tumor site (52.4%). The most common histological subtype of tumor was embryonal RMS (85.7%). The most common measured diameter for tumor size was ≤ 5 cm (42.9%). Almost half of the patients received combination therapy, including surgery and chemotherapy (47,6%). Overall survival rate was 71.7%. Conclusion: We concluded that the epidemiological profile and prognostic factors of childhood RMS patients in our center are similar to the world reference data and were clinically associated with the mortality rate of our RMS patients, but the findings were not considered statistically significant.