No abstract available.
Rickets, Hypophosphatemic*

No abstract available.
Rickets, Hypophosphatemic*

No abstract available.
Rickets, Hypophosphatemic*

Chronic hypophosphatemia caused by decreased intestinal absorption or increased renal clearance, may lead to rickets or osteomalacia independently of other predisposing abnormalities. The conditions commonly associated with increased renal clearance of phosphate are X-linked hypophosphatemic rickets, tumor associated rickets/osteomalacia, RTA and Fanconi syndrome. Recently we experienced 3 men with adult-onset, histologically proven osteomalacia associated with increased renal clearance of phosphate. None of them had a family history of bone disease, tumors or other tubular defects. All of these had remarkable biochemical and clinical improvement with medical treatment such as 1, 25-dihydroxyvitamin D and phosphate supplementation. Although we did not find tumors yet, we could not rule out the possibility of tumor-associated osteomalcia since it often takes several years to make a diagnosis because of small size, benign nature and unusual location of tumors. Thus, careful long-term follow up for tumor occurrence will be maintained in these patients with sporadic nonfamilial hypophosphatemic osteomalacia.
Bone Diseases ; Diagnosis ; Familial Hypophosphatemic Rickets ; Fanconi Syndrome ; Follow-Up Studies ; Humans ; Hypophosphatemia ; Intestinal Absorption ; Male ; Osteomalacia ; Rickets

Acute renal infarction is an uncommon disease that is often misdiagnosed initially because of its nonspecific presentation. Cardiovascular disease is the major cause of thromboembolic event, but renal infarction can also occur in patient with special conditions such as hypercoagulable states. Protein S deficiency is a rare cause of the hypercoagulable states and induces both venous and arterial thrombosis. Protein S are a vitamin K dependent plasma protein that serves as a cofactor for the anticoagulant effects of activated protein C. Patients deficient in protein S is prone to recurrent thromboembolic disease. We reported a case of acute renal infarction that was associated with type II protein S deficiency in a 38-year old patient without underlying cardiovascular disease.
Cardiovascular Diseases ; Humans ; Infarction ; Plasma ; Protein C ; Protein S ; Protein S Deficiency ; Thrombophilia ; Thrombosis ; Vitamin K

This study was done to evaluate the health and nutritional status of female college students in Seoul. The subjects were 63 healthy college students aged 20 to 29 years. Their body composition, dietary intakes, clinical blood indices were investigated. Their body composition was determined by means of a multifreqency bioelectrical impedance analysis. Their dietary intake was determined using 3-day record method and their nutrient intake was analyzed by Computer Aided Nutritional analysis program for professional (CAN-pro). Their hemoglobin, hematocrit, red blood cell (RBC), white blood cell (WBC) and mean corpuscular volume (MCV) were determined by semi-automated microcell counter (F-520). Their plasma total cholesterol, TG, and HDL-cholesterol levels were measured using test kits. All data were statistically analyzed by SAS PC package program. Their average consumption of calcium, iron vitamin A, vitamin B2 and niacin were 63.3%, 65.0%, 85.2%, 89.2% and 95.2% of RDA, respectively. The overall mean values of the hematological indices in the female college students were within the normal range. However anemic subjects with hemoglobin (< 12 g/dl) and hematocrit (< 36%) accounted for about 20% of the subjects. The mean levels of total cholesterol, HDL-cholesterol and TG were 188.4 mg/dl, 69.9 mg/dl and 67.4 mg/dl, respectively. The percentages of the subjects with plasma total cholesterol level (> 200 mg/dl) and LDL-cholesterol (> 130 mg/dl) were about 41% and 30.4%, respectively. The data showed a significantly positive correlation between either body fat (%) or BMI and TG. However, there was a significantly negative correlation between either body fat (%) or BMI and HDL-cholesterol. These overall results suggest that it is necessary for college women to be educated regarding consuming more iron and vitamin C and less fat, in order to prevent iron deficiency anemia and/or cardiovascular diseases in later life.
Adipose Tissue ; Anemia, Iron-Deficiency ; Ascorbic Acid ; Body Composition* ; Calcium ; Cardiovascular Diseases ; Cholesterol ; Eating* ; Electric Impedance ; Erythrocyte Indices ; Erythrocytes ; Female* ; Hematocrit ; Humans ; Iron ; Leukocytes ; Niacin ; Nutritional Status ; Plasma ; Reference Values ; Riboflavin ; Seoul ; Vitamin A

In this report, we describe the case of a healthy 37-year-old male patient without a history of disease, who developed atraumatic bilateral fracture of the femoral neck. Radiological and blood investigations revealed osteopenia and severe vitamin D deficiency (7.42 ng/mL), respectively, but patient had no apparent risk factors for insufficiency fracture. Bilateral osteosynthesis was obtained using cannulated screws and laboratory findings improved after vitamin D supplementation. This case highlights the effect of vitamin D deficiency on demineralization in a young male patient.
Adult ; Bone Diseases, Metabolic ; Femur Neck* ; Fractures, Stress ; Humans ; Male* ; Osteomalacia* ; Risk Factors ; Vitamin D ; Vitamin D Deficiency

Hypophosphatemic vitamin D resistant rickets is a form of rickets characterized by typical structural deformities and roentgenographic and metabolic changes. It has a strong familial tendency and appear to be genetically transmitted. Authors experienced 7 patients with hypophosphatemic vitamin D resistant rickets which have been manifested through three generation in a family at Won-Kwang University Hospital from Dec.1982 to May1984. Authors studied hypophosphatemic vitamin D resistant rickets clinically, radiologically, biochemically andpathologically, and reported with review of literatures.
Congenital Abnormalities ; Humans ; Rickets ; Rickets, Hypophosphatemic

Vitamin D is an important hormone that can be a role of bone and calcium metabolism in the human organ. Thus, vitamin D deficiency could contribute to the severity of metabolic bone disease. The osteomalacia, one of the metabolic bone diseases, is the softening of the bones caused by defective bone mineralization secondary to inadequate amounts of available phosphorus and calcium. We experienced a case of osteomalacia presented with walking disturbance, 30 year-old young aged man, caused by vitamin D deficiency due to strict vegetarian diet and lack of sunlight exposures.
Aged ; Bone Diseases, Metabolic ; Calcification, Physiologic ; Calcium ; Diet, Vegetarian ; Humans ; Male ; Osteomalacia ; Phosphorus ; Sunlight ; Vitamin D ; Vitamin D Deficiency ; Walking ; Young Adult

BACKGROUND/AIMS: The exact relationship between vitamin D deficiency and inflammatory bowel disease (IBD) remains unclear. We evaluated the effect of vitamin D3 administration on inflammatory responses and disease severity in patients with IBD. METHODS: We investigated the serum 25-hydroxyvitamin D3 [25-(OH)D], C-reactive protein (CRP) levels and the partial Mayo score (PMS) in patients with IBD. Vitamin D3 was administered in patients with either vitamin D deficiency or insufficiency and CRP, serum vitamin D levels and PMS were re-examined at 6 months of administration. RESULTS: In 88 patients with Crohn's disease (CD), a negative correlation was found between serum vitamin D and CRP. In 178 patients with ulcerative colitis (UC), serum vitamin D showed no association with CRP or PMS. Serum vitamin D increased from 11.08±3.63 to 22.69±6.11 ng/mL in 29 patients with CD and from 11.45±4.10 to 24.20±6.61 ng/mL in 41 patients with UC who received vitamin D3 treatment (P<0.001 and P<0.001, respectively). In patients with CD, median ΔCRP was –0.24 in the normalized vitamin D group and –0.11 in the non-normalized group (P=0.308). In patients with UC, median ΔCRP was −0.01 in the normalized vitamin D group and 0.06 in the non-normalized group (P=0.359). CONCLUSIONS: Although a negative correlation was found between serum vitamin D and CRP levels in patients with CD, administration of vitamin D did not improve the CRP level in patients with CD. In patients with UC, serum vitamin D level was unrelated to CRP or PMS.
C-Reactive Protein ; Calcifediol ; Cholecalciferol ; Colitis, Ulcerative ; Crohn Disease ; Humans ; Inflammatory Bowel Diseases ; Vitamin D Deficiency ; Vitamin D ; Vitamins