Objective To evaluate the efficacy and safety of chinese mednine in treatment of avascular necrosis by evidence-based medicine principles.Methods Search 1994-2010 Chinese full-text periodical database,VIP Articles journal database and the Wanfang database have been published in the medical treatment of avascular necrosis of the clinical trial literature,Revman 4.2 software was used for statistical analysis.Results A total of 11 randomized controlled trials included 1490 cases of patients meet the criteria,compared with the control group of traditional Chinese medicine treatment of avascular necrosis of the efficiency test results of the analysis of the merger:Z =2.89,P ＜ 0.01,the combined RR of 2.00,95％ confidence interval(1.25,3.19); All trials were not reported significant adverse reactions.Conclusion Chinese medicine treatment of avascular necrosis had good efficacy and safety.