1.Smart tracking and subtraction combined with scan application in the cerebral CT angiography
Chongqing Medicine 2014;(23):3045-3047
Objective To explore CT angiography(CTA) method for the influence of the cerebral angiography ,looking for dif-ferent situations using which kind of scan mode can achieve the best results .Methods 350 CTA patients were selected and tested by 4 kinds of scanning methods which were subtraction scan (236) ,experience value scan (13) ,smart tracking scan (68) ,smart tracking and subtraction combined(33) .To compare and analyze that four kinds of scanning methods ,to explore which kind of method under what circumstances can get the best examination results .Results Smart tracking and subtraction combined with scan method and subtraction scan method for excellent rate of image quality were 93 .93% and 93 .64% respectively ,there were no sig-nificant statistical differences between them .Experience value method and smart tracking method for excellent rate of image quality were only 76 .92% and 66 .18% ,there was significant difference in statistics .Conclusion Subtraction scan can be used as a conventional scan method .In low dose test bolus of time-density curve detection failure cases ,smart tracking and subtraction combined with scan method was used to get the image quality with subtraction scan method ,it is an effective complement of subtraction scan method ,is worth generalization .
2.Research progress in the study of protective effect of tanshinone IIA on cerebral ischemic stroke.
Dechuan LI ; Xiuqi BAO ; Hua SUN ; Dan ZHANG
Acta Pharmaceutica Sinica 2015;50(6):635-9
Danshen is one of the traditional Chinese herbal medicines and nas a long history or being used clinically in the treatment of cardiovascular and cerebrovascular conditions such as coronary heart disease and angina pectoris. Tanshinone IIA is a derivative of phenanthrene-quinone isolated from Danshen. It has been reported to be the major bioactive compound of Danshen and has diverse biological effects. Recent studies demonstrated that tanshinone IIA had neuroprotective effects on experimental ischemic stroke through its antiinflammatory, anti-oxidant, anti-apoptosis effects and its inhibitory effect on excitatory amino acid toxicity. In this review, we summarized all the recent progresses on the protective effect of tanshinone IIA on cerebral ischemic stroke. Hopefully, this article will throw some light on further study and application of tanshinone IIA.
3.The anti-neuroinflammatory effects of dehydromiltirone and related mechanisms
Dechuan LI ; Xiuqi BAO ; Dewu ZHANG ; Hua SUN ; Jungui DAI ; Dan ZHANG
Chinese Pharmacological Bulletin 2016;(2):177-183
Aim To investigate the anti-neuroinflam-matory activities of dehydromiltirone and the underlying mechanisms in LPS-stimulated microglial cell line BV2 cells. Methods BV2 cells were pre-treated with de-hydromiltirone, then stimulated by LPS. The levels of nitric oxide( NO) were measured by Griess assay, and the concentrations of pro-inflammatory cytokines were measured by ELISA assay. Confocal fluorescence mi-croscopy was used to measure the expression of MAC-1, the biomarker of activated BV2 cells. The levels of-inducible nitric oxide synthase ( iNOS ) , cyclooxygen-ase-2 ( COX-2 ) , NF-κB and PI3 K/Akt were deter-mined by Western blot analysis. Results The treat-ment of dehydromiltirone significantly inhibited the pro-duction of NO, TNF-α and IL-6, attenuated the ex-pression of iNOS and COX-2 protein, and dampened the microglial activation in LPS-stimulated BV2 cells. The mechanistic study revealed that dehydromiltirone inhibited the phosphorylation of PI3 K and Akt in LPS-stimulated BV2 cells, and decreased NF-κB activation by suppressing the degradation of IκB. Conclusion dehydromiltirone shows significant anti-neuroinflamma-tory effects through inhibiting PI3 K/Akt phosphoryla-tion and then inhibiting NF-κB signaling pathway.
4. Qualitative study on unprotected sexual behaviors among male students who have sex with men in Beijing
Dechuan ZHANG ; Zihuang CHEN ; Yue MA ; Zunyou WU
Chinese Journal of Preventive Medicine 2018;52(12):1234-1238
Objective:
To investigate the related factors of unprotected sexual behaviors among male students who have sex with men in Beijing.
Methods:
Male students who have sex with men were recruited from May 2018 to July 2018 at two voluntary counseling and testing (VCT) clinics in Beijing by convenient sampling method. Information being collected during in-depth personal interviews with a semi-structured outline included ways to seek sexual partners, sexual partners characteristics, attitude of condom use, incidence and causes of unprotected sexual behaviors, rush poppers and alcohol use. The text information was summarized and analyzed by Nvivo 11.0 software.
Results:
A total of 35 male students who have sex with men were recruited and interviewed, the median of age was 22 years old (
5.Features of severe acute respiratory syndrome coronavirus 2 co-infected with other common respiratory pathogens in Shanghai City, 2020-2021
Qi QIU ; Dechuan KONG ; Zheng TENG ; Yanqiu ZHOU ; Hongyou CHEN ; Xi ZHANG ; Jian CHEN ; Yaxu ZHENG ; Xianjin JIANG ; Shiying YUAN ; Huanyu WU ; Hao PAN ; Xiaodong SUN
Chinese Journal of Infectious Diseases 2023;41(4):249-254
Objective:To analyze the features of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) co-infected with other common respiratory pathogens among coronavirus disease 2019 (COVID-19) patients in Shanghai City, and to provide a reference for scientific prevention and control of COVID-19 and other respiratory infectious diseases.Methods:Descriptive epidemiological approaches were used to analyze the data of COVID-19 reported cases in Shanghai City from January 2020 to February 2021 in the information system of Chinese Disease Prevention and Control. Clinical data of the participants were collected, and their SARS-CoV-2 nucleic acid-positive respiratory specimens were collected at the time of illness onset or admission. Multiplex reverse transcription-polymerase chain reaction (RT-PCR) was performed to detect the 22 respiratory pathogens. Independent-samples t test was used for statistical analysis. Results:Of the 272 patients with COVID-19, 15(5.5%) had co-infection of SARS-CoV-2 with other respiratory pathogens, all of which were double infection. There were three cases infected with enterovirus/rhinovirus, two of each with adenovirus, human metapneumovirus and coronavirus NL63/HKU1, and one of each with coronavirus 229E, influenza A virus H1N1, parainfluenza virus 1 and respiratory syncytial virus B. Two cases infected with Mycoplasma pneumoniae. Among the 272 COVID-19 patients, 212(77.9%) had fever, 117(43.0%) had cough, 46(16.9%) had fatigue, and 35(12.9%) had sore throat. The white blood cell count of co-infection cases was higher than that of non-co-infection cases ((6.8±1.7)×10 9/L vs (5.3±1.6)×10 9/L), and the difference was statistically significant ( t=3.09, P=0.008). Conclusions:There is a certain proportion of co-infection of SARS-CoV-2 with other respiratory pathogens among the COVID-19 cases in Shanghai City, mainly viral pathogens, especially enterovirus/rhinovirus. A rational combination of drugs was recommended to improve the cure rate. Surveillance of acute respiratory infection should be further strengthened as well.
6.Value of chest high-resolution CT score in severity assessment of hip fracture-induced early acute lung injury in elderly patients
Xi LIU ; Lei LIU ; Hua YANG ; Qin ZHANG ; Li TIAN ; Dechuan ZHANG ; Huiping YANG ; Huixu MA
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery 2021;28(06):714-719
Objective To investigate the value of chest high-resolution computed tomography (HRCT) score in evaluating the severity of hip fracture-induced early acute lung injury (ALI) in the elderly patients. Methods The clinical data of 289 elderly hip fracture patients in Chongqing Traditional Chinese Medicine Hospital from July 2014 to April 2020 were retrospectively analyzed. All patients were divided into two groups, including an ALI group (n=114, 36 males and 78 females at age of 82.94±6.85 years) and a non-ALI group (n=175, 51 males and 124 females at age of 84.42±6.31 years). General information, chest HRCT scores and PaO2/FiO2 were compared between the two groups. Correlation analysis was used to compare the relationship between chest HRCT scores and PaO2/FiO2. Multiple linear stepwise regression analysis was applied to evaluate the effective extent of the diffuse ground glass opacity (DGGO), intense parenchymal opacification (IPO), and reticulation HRCT scores to the overall HRCT scores. Results The DGGO scores, IPO scores, reticulation scores, overall HRCT scores and PaO2/FiO2 were higher in the ALI group than those in the non-ALI group (P<0.001). In the ALI group, correlation analysis showed that DGGO, overall HRCT scores were in significantly negative correlation with PaO2/FiO2 (P<0.001). In addition, the correlation among PaO2/FiO2 and overall HRCT scores was more significant than that of DGGO scores. Multiple stepwise regression analysis indicated that DGGO, IPO, and reticulation scores were independent influencing factors for overall HRCT scores. Among the influencing factors, DGGO scores had the greatest impact, then IPO scores and reticulation scores. The HRCT signs of DGGO, IPO, and reticulation appeared simultaneously had the greatest effects on the overall HRCT scores. Conclusion The chest HRCT score, which is associated with PaO2/FiO2, also can be used in the severity assessment of elderly patients with early ALI caused by hip fracture.
7.Study on the effect of nursing-technology integrated in the imaging examination of Novel coronavirus pneumonia
Dechuan ZHANG ; Changsu LAI ; Juan YI ; He REN ; Yu FANG ; Yang JIANG ; Chen FENG ; Xuqian LIANG ; Huiping YANG ; Hua YANG
Chongqing Medicine 2020;49(0):E019-E019
Currently, the outbreak of the new coronary pneumonia has entered a critical period of screening, prevention and control.In order to block the transmission of the virus in the radiology department, it is particularly important to effectively protect the medical servant while speeding up the flow of inspection.Based on the basis of notification of the bureau of disease control and prevention, the expert consensus of the CMA and CMDA, and the literature review, combined with the previous practical work experience,this article puts forward the recommendations on the important effect of nursing-technology integrated in the imaging examination of novel coronavirus pneumonia, in order to provide reference for the protection of medical servant in the radiology department at the front line of anti-epidemic.
8. Etiologic and epidemiologic features of acute respiratory infections in adults from Shanghai, during 2015-2017
Dechuan KONG ; Huanyu WU ; Yaxu ZHENG ; Hao PAN ; Chenyan JIANG ; Xi ZHANG ; Jian CHEN ; Fan WU
Chinese Journal of Epidemiology 2019;40(8):904-910
Objective:
To analyze the etiologic and epidemiological characteristics of adult acute respiratory infections in Shanghai during 2015-2017.
Methods:
Data was collected from outpatients with acute respiratory infections who visited the Fever Clinics in three hospitals of different levels in three administrative regions of Shanghai, from 2015 to 2017. Basic information and nasopharyngeal swabs were collected from cases in line with the inclusion criteria. Multiplex RT-PCR and bacterial cultures were performed to detect the respiratory pathogens.
Results:
A total of 806 individuals were enrolled from 2015 to 2017. Respiratory pathogens were identified in 73.45% (592/806) of the cases, with the virus detection rate as 66.75% (538/806). It was found that the major respiratory pathogens for virus detection were influenza A in 326 (40.45%), influenza B in 116 (14.39%), rhinovirus/enterovirus in 39 (4.84%) of the cases. The overall detection rate of bacteria was 16.13% (130/806), including Klebsiella pneumoniae in 90 (11.17%) cases, Staphylococcus Aureus in 46 (5.71%) cases. Other kind of bacteria were not detected in our study. The detection rates on Mycoplasma pneumoniae was 5.33% (43/806) and on Chlamydia pneumonia was 0.37% (3/806). Co-infection with multiple pathogens was detected in 18.61% (150/806) of the cases, including 135 with double infection (accounting for 90.00%), 14 with triple infection and 1 with quadruple infection (accounted for 9.33% and 0.67%, respectively). Among the 150 cases with co-infections, the main identified pathogens were influenza A, Klebsiella pneumoniae, Staphylococcus aureus, and Mycoplasma pneumoniae. Pathogens of acute respiratory infections that identified among the outpatients from the Fever Clinics at different time, region or population, the characteristics were different (