1.Progress of sudden unexpected death in epilepsy.
Chinese Journal of Pediatrics 2014;52(11):828-830
Death, Sudden
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etiology
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Epilepsy
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complications
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mortality
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Humans
2.Risk factors and warning signs of sudden cardiac death.
Acta Academiae Medicinae Sinicae 2008;30(2):218-223
Sudden cardiac death (SCD) is the most common death mode. No test has been able to accurately predict SCD. This article reviews the risk factors and warning signs of SCD with an attempt to effectively prevent SCD events.
Death, Sudden, Cardiac
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etiology
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pathology
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prevention & control
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Humans
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Risk Factors
5.Cardiac Disease Associated Genetic Variants in Yi Nationality in Regions with High Incidence of Yunnan Sudden Unexplained Death.
Kai LIU ; Yue Bing WANG ; Jin Liang DU ; Peng Fei QU ; Lin MA ; Xue TANG ; Yan Mei XI ; Yong Qiang QU ; Yu Hua LI ; Pu Ping LEI ; Sheng Jie NIE
Journal of Forensic Medicine 2020;36(4):497-501
Objective To explore the association of cardiac disease associated genetic variants and the high incidence of Yunnan sudden unexplained death (YNSUD) in Yi nationality. Methods The genomic DNA was extracted from peripheral blood samples collected from 205 Yi villagers from YNSUD aggregative villages (inpatient group) and 197 healthy Yi villagers from neighboring villages (control group). Fifty-two single nucleotide variants (SNVs) of 25 cardiac disease associated genes were genotyped using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS). The SPSS 17.0 was used to analyze data. The pathogenicities of variants with differences between the two groups that have statistical significance were predicted by protein function prediction software PolyPhen-2 and SIFT. All villagers from inpatient group were given electrocardiogram (ECG) examination using a 12-lead electrocardiograph. Results The allele frequency and the genotype frequency of missense mutation DSG2 (rs2278792, c.2318G>A, p.R773K) of pathogenic genes of arrhythmogenic right ventricular cardiomyopathy (ARVC) in inpatient group was higher than that in control group (P<0.05). Abnormal ECG changes were detected in 71 individuals (34.6%) in the inpatient group, among which 54 individuals carried R773K mutation, including clockwise (counterclockwise) rotation, left (right) axis deviation, ST segment and T wave alteration and heart-blocking. Conclusion Definite pathogenic mutations have not been found in the 52 cardiac disease genes associated SNVs detected in Yi nationality in regions with high incidence of YNSUD. The cause of high incidence of YNSUD in Yi nationality needs further study.
Arrhythmogenic Right Ventricular Dysplasia
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China/epidemiology*
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Death, Sudden/etiology*
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Death, Sudden, Cardiac/etiology*
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Ethnicity/genetics*
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Humans
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Incidence
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Mutation
6.Common underlying diseases do not contribute in determining the causes of sudden unexplained death.
Zhao-xing TIAN ; Yan-yu LÜ ; Chetan Rai NUGESSUR ; Wei YAN ; Wen-kui ZHAO ; Li-li KONG ; Ya-an ZHENG
Chinese Medical Journal 2013;126(5):870-874
BACKGROUNDUnderlying diseases have a statistically significant positive correlation to sudden death. However, sudden unexplained death (SUD) is different from sudden death, as there is no clinical evidence to support the sudden death due to the original underlying disease, nor a lethal pathological basis to be found during autopsy. In addition, SUD are more common in young, previously healthy individuals, usually without any signs of disease, with no positive lesions found after autopsy. Therefore, a causal relationship between SUD and the underlying disease needs to be further explored. This study aimed to explore the role that common underlying diseases play in patients with SUD and to reveal the correlation between them.
METHODSThe medical records, history and case information of 208 patients with SUD were collected for the survey. All these SUD occurred in the emergency room of Peking University Third Hospital from January 2006 to December 2009. The patients were stratified by with and without common underlying diseases. To examine possible associations between the underlying diseases and the cause of unexplained sudden death, the chi-squared and Fisher's exact tests were used.
RESULTSAmong the 208 patients, 65 were diagnosed with common underlying diseases while 143 were not. Within these two groups, there were 45 patients for whom the clear cause of death was determined. However, there were no statistically significant differences or strong associations (χ(2) = 1.238, P > 0.05) between the 11 patients with (16.90%) and 34 without (23.78%) common underlying disease among these 45 patients. We also found that occurrence of the common underlying diseases, such as neurological system, cardiovascular and pulmonary system diseases, are not statistically significant (P > 0.05) in the diagnosis of the SUD.
CONCLUSIONCommon underlying diseases make no obvious contributions to SUD and are not useful in diagnosing the underlying reasons for death.
Adolescent ; Adult ; Aged ; Cause of Death ; Death, Sudden ; epidemiology ; etiology ; Female ; Humans ; Male ; Middle Aged ; Young Adult
7.Male Pseudohermaphroditism Presented with Sudden Cardiac Arrest.
Jaemin SHIM ; Hye Jin HWANG ; Hui Nam PAK ; Moon Hyoung LEE ; Boyoung JOUNG
Yonsei Medical Journal 2012;53(3):658-661
Torsades de Pointes is a life-threatening arrhythmia associated with a number of causes, but is very rare among endocrinologic disorders. We report a case of male pseudohermaphroditism with hyperaldosteronism due to a 17alpha-hydroxylase deficiency presented with sudden cardiac arrest.
46, XY Disorders of Sex Development/*diagnosis/drug therapy
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Adult
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Death, Sudden, Cardiac/*etiology/*pathology
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Female
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Humans
8.A case report of sudden death caused by carcinoma of nasal sinuses with a huge liquid mass in cranial cavity.
Jia-xiong ZHANG ; Wen-tao ZOU ; Xiao-jing CAI
Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2012;47(11):948-948
Adult
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Brain Neoplasms
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complications
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Death, Sudden
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etiology
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Female
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Humans
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Nose Neoplasms
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complications
9.One case report of sudden death due to ruptured aortic sinus aneurysm into right ventricle.
Hui-fang MA ; Guo-hua XUE ; Shou-yan ZHANG
Chinese Journal of Cardiology 2011;39(11):1048-1049
Adult
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Aortic Rupture
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pathology
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Death, Sudden, Cardiac
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etiology
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Heart Ventricles
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pathology
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Humans
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Male
10.Research Progress of the Relationship between SUNDS and OSAHS.
Ye Da WU ; Li Yong ZHANG ; Jian Ding CHENG
Journal of Forensic Medicine 2017;33(1):52-57
Sudden unexplained nocturnal death syndrome (SUNDS) is always a difficulty in forensic medicine researches. Although the development of molecular genetics promotes the etiologic study of SUNDS, the pathogenesis of most such cases is still unclear. Sleep apnea syndrome (SAS) is one of the common forms of sleep disorders, and obstructive sleep apnea hypopnea syndrome (OSAHS) is the most common. In recent years, some domestic and international researches show that OSAHS is related to the development of cardiovascular disease, which may cause cardiac arrhythmia, even sudden death. This article reviews the relationship between SUNDS and OSAHS and aims to provide new ideas for the pathogenesis of SUNDS.
Arrhythmias, Cardiac
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Brugada Syndrome/pathology*
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Death, Sudden/etiology*
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Humans
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Male
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Sleep Apnea, Obstructive/pathology*