China ; Deafness ; genetics ; Humans

192 children with sensorineural deafness were included in this study. The most of children were diagnosed late with ages over 24 months (92%). Only 18% of children were discovered early and instantly examined in otorhinolarygologic facilities, while 72% of children were treated when they were at school ages. Among 99% of children with severe deafness, 68% had deafness due to flare-up of the fire of the liver and gall bladder and 32% of cases with deafness due to insufficiency of the Yin or the liver and kidney. Congenital deafness only accounted for 8% of cases, while the most of cases with deafness were resulted from preventable causes, out of them 28% of cases with deafness related to pregnancy and childbirth and 20% of cases with deafness related to the administration of aminosids
Deafness ; Child ; Risk Factors

Blast Injuries ; Deafness ; etiology ; Humans

1. Audiometiric examination for 14 cases of retinal pigmentary degeneration revealed a case of conductive deafness, and 4 cases of perceptive hearing disturbances. 2. There were no complaints of subjective hearing disturbances among the cases of perceptive hearing impairments. 3. All the cases of perceptive hearing loss were thought to be due to cochlear lesion according to tone decay tests. 4. There were no cases accompanied by systemic or neuropsychiatric disorders among the 14 cases of retinal pegmentary degeneration. 5. It has been emphasized that pigmentery degeneration of the retina is frequently associated with perceptive hearing disturbances. Genetical and etiological discussions were tried for this association.
Deafness ; Hearing Loss ; Hearing* ; Retina* ; Retinaldehyde

Audiology ; Deafness ; genetics ; Humans ; Otolaryngology ; trends

DNA, Mitochondrial ; genetics ; Deafness ; genetics ; Humans ; Mutation

Cochlea ; metabolism ; Deafness ; genetics ; Humans ; Mutation

Deafness ; diagnosis ; genetics ; Genetic Counseling ; Humans

Electro-acupuncture was applied for 149 perceptive deaf children. The control group included 43 deaf children treated by speical education method. Results showed that: in the group of electro-acupuncture, 53.3% had got improvement, higher than the group of special education by 23.3%. The improvement rate was higher in mild deaf group, than in severe group. It was also higher in acquired deaf subjects than in congenital subjects. In the deaf caused by “can dom hoa cuong” (aggressive fire of liver and bile), improvement level was higher than the deaf caused by “than am hu” (failure of kidney yinn). The treatment with more courses had got higher improvement than with less courses.
Rehabilitation of Hearing Impaired ; Child ; Deafness ; Electroacupuncture

Hearing loss is a common sensory deficit in humans. The hearing loss may be conductive, sensorineural, or mixed, syndromic or nonsyndromic, prelingual or postlingual. Due to the complexity of the hearing mechanism, it is not surprising that several hundred genes might be involved in causing hereditary hearing loss. There are at least 82 chromosomal loci that have been identified so far which are associated with the most common type of deafness--non-syndromic deafness. However, there are still many more which remained to be discovered. Here, we report the mapping of a locus for autosomal recessive, non-syndromic deafness in a family in Malaysia. The investigated family (AC) consists of three generations--parents who are deceased, nine affected and seven unaffected children and grandchildren. The deafness was deduced to be inherited in an autosomal recessive manner with 70% penetrance. Recombination frequencies were assumed to be equal for both males and females. Using two-point lod score analysis (MLINK), a maximum lod score of 2.48 at 0% recombinant (Z = 2.48, theta = 0%) was obtained for the interval D14S63-D14S74. The haplotype analysis defined a 14.38 centiMorgan critical region around marker D14S258 on chromosome 14q23.2-q24.3. There are 16 candidate genes identified with positive expression in human cochlear and each has great potential of being the deaf gene responsible in causing non-syndromic hereditary hearing loss in this particular family. Hopefully, by understanding the role of genetics in deafness, early interventional strategies can be undertaken to improve the life of the deaf community.
Deafness ; Family ; Relationship by association ; MALAYSIAN ; Linkage (Genetics)