1.Efficacy of Interferon-alpha2b in Treatment of Warts.
Kyung Lok KIM ; Jung Sub YEUM ; Seong Eon KIM ; Dea Won KOO ; Ai Young LEE
Korean Journal of Dermatology 2005;43(10):1326-1331
BACKGOUND: Interferon-alpha2b has already proven to be effective in the clinical treatment of virus-originated diseases such as hairy cell leukemia, condyloma acuminatum, and AIDS-related Kaposi's sarcoma. The use of recombinant interferon-alpha2b may allow various types of wart to be treated relatively atraumatically and with less incidence of recurrence. OBJECTIVE: We tried to compare the effectiveness and safety of intralesional injections of recombinant interferon-alpha2b with natural interferon-alpha2b in the treatment of patients with various types of wart. METHOD: Patients with more than two warts were treated by injecting the different warts with 0.5 to 1.0X105 IU/1mm3 of recombinant and natural interferon-alpha2b, twice per week for 4 to 20 weeks. The response to treatment was followed up at 36 weeks. RESULTS: At the end of treatment, clearing of the treated warts had occurred in 83.3% of the recombinant interferon-alpha2b group and 91.6% of the natural interferon-alpha2b group. A more rapid cure rate was observed in the natural interferon-alpha2b group than in the recombinant interferon-alpha2b group. The rest showed partial improvement. With evaluation for relapse up to 16 weeks after treatment, warts were found to relapse in 11.1% of both the recombinant and natural interferon groups. CONCLUSION: Intralesional natural interferon-alpha2b has a better therapeutic effect than recombinant interferon-alpha2b, and may be considered as a therapeutic modality of recalcitrant verruca or when it can be anticipated that destructive techniques or blistering agents will not be tolerated.
Blister
;
Humans
;
Incidence
;
Injections, Intralesional
;
Interferons
;
Leukemia, Hairy Cell
;
Recurrence
;
Sarcoma, Kaposi
;
Warts*
2.Alteration of Nitric Oxide Synthase Subtype Expression in Contralateral Testis of Rat in Response to Unilateral Testicular Torsion Followed by Detorsion.
Seung June OH ; Chang Shin PARK ; Kyung Hoon LEE ; Dae Joong KIM ; Dea Jung LIM ; Jin Ren JIE ; Ahn Ki LEE ; Hwang CHOI
Korean Journal of Urology 2000;41(5):650-658
No abstract available.
Animals
;
Nitric Oxide Synthase*
;
Nitric Oxide*
;
Rats*
;
Spermatic Cord Torsion*
;
Testis*
3.Development and Migration of Megakaryocyte during Hepatic Hemopoiesis in Human Fetuses.
Won Bok LEE ; Chang Whun LEE ; Bong Soo CHUNG ; Bum Soo KIM ; Dea Jin KIM ; Sung Soo KIM ; Kyung Yong KIM
Korean Journal of Anatomy 2002;35(4):285-296
Liver tissuses obtained from 5 human fetuses between 11 weeks and 23 weeks of gestation during the high activity of hepatic hemopoiesis were observed with transmission electron microscope using continuous series of thin sections. The objective of present study was to evaluate ultrastructures of megakaryopoietic cells, the migration of extravascular megakaryocyte into the sinusoidal lumen and the relevence between a migrated megakaryocyte and a Kupffer cell. Immature megakaryocytes were usually observed between growing hepatic laminae and within hepatic sinusoids. A megakaryoblast contained numerous polyribosomes, rather large mitochondria, short tubular elements of rough endoplasmic reticulum and small granules. Moreover, demarcation tubules and a few small specific granules were observed in immature megakaryocytes. The nucleus was mononuclear but frequently indented. With maturation, the nuclei were multilobulated. In the cytoplasm, in contrast to the decrease in polyribosomes and rough endoplasmic reticulum, the numerous specific granules and well -developed demarcation membrane system were predominant. Thereafter cytoplasmic zonation was observed clearly in maturing and mature megakaryocytes. Some megakaryocytes passed through the sinusoidal lining epithelium and into the hepatic sinusoids. The cell to cell interaction was often found as adhesion between migrated megakaryocyte and Kupffer cell, and erythroblasts within megakaryocyte (emperipolesis). These results suggest that intravascular megakaryopoiesis in addition to extravascular megakaryopoiesis occurs to produce platelet during the human fetal liver.
Blood Platelets
;
Cell Communication
;
Cytoplasm
;
Emperipolesis
;
Endoplasmic Reticulum, Rough
;
Epithelium
;
Erythroblasts
;
Fetus*
;
Humans*
;
Liver
;
Megakaryocyte Progenitor Cells
;
Megakaryocytes*
;
Membranes
;
Mitochondria
;
Polyribosomes
;
Pregnancy
;
Thrombopoiesis
4.The Effect of a Left Stellate Ganglion Block on Left Ventricular Function.
Jeong Uk HAN ; Cheong Kweon CHUNG ; Tae Jung KIM ; Choon Soo LEE ; Young Deog CHA ; Je Dong OH ; Hyun Kyung LIM ; Jeong Kee SEO ; Dea Hyeok KIM ; Chul Ho LEE
Korean Journal of Anesthesiology 2000;39(6):798-803
BACKGROUND: A Stellate ganglion block (SGB) is a sympathetic nerve block method which has been used most frequently in pain clinics due to its wide range of indications. However, SGB leads to regional sympathetic denervation of the heart and to changes in the hemodynamics. The aim of this study was to compare hemodynamic effects as well as echocardiographic changes after a left SGB (LSGB). METHODS: Fourteen healthy male volunteers were studied. The LSGB was performed with 1% mepicacaine 6 ml. Arterial blood pressure, electrocardiographic and echocardiographic variables were measured before the LSGB, 15 and 30 minutes after the LSGB. RESULTS: Arterial blood pressure, ejection fraction and transmitral inflow velocity variables showed no significant changes compared to pre-LSGB values. P-P interval increased significantly 15 minutes after the LSGB, and the Q-T interval increased significantly 30 minutes after the LSGB. The diastolic pulmonary venous flow velocity decreased significantly 15 minutes after the LSGB. CONCLUSIONS: These results showed that a LSGB decreased the heart rate without detrimental changes of left ventricular relaxation in healthy male volunteers.
Arterial Pressure
;
Autonomic Nerve Block
;
Echocardiography
;
Electrocardiography
;
Heart
;
Heart Rate
;
Hemodynamics
;
Humans
;
Male
;
Pain Clinics
;
Relaxation
;
Stellate Ganglion*
;
Sympathectomy
;
Ventricular Function, Left*
;
Volunteers
5.A case of transient mid-ventricular ballooning syndrome.
Hyun Hee CHOI ; Young Mook KIM ; Dea Yong KIM ; Jue Yong LEE ; In Sang YUN ; Sang Jin HAN ; Kyung Soon HONG
Korean Journal of Medicine 2008;74(3):321-324
Transient left ventricular apical ballooning syndrome is also known as takotsubo cardiomyopathy, and this is characterized by transient wall-motion abnormalities involving the left ventricular apex without significant stenosis on the coronary angiogram. We report here on a new variant of transient left ventricular ballooning in which only the mid-ventricle was affected. The patient initially presented with dyspnea and she had wall-motion abnormalities involving the mid-ventricle with hypercontractility of the apical and basal segments in the absence of a significant coronary artery stenosis. Emotional or physical stress or other preceding triggering factors might play a key role in this cardiomyopathy, but the precise etiology remains unknown. So far, the cases of this syndrome have been reported only among the North America Caucasian population and the Japanese population.
Asian Continental Ancestry Group
;
Cardiomyopathies
;
Constriction, Pathologic
;
Coronary Stenosis
;
Dyspnea
;
Humans
;
North America
;
Takotsubo Cardiomyopathy
6.A Case of Synchronous Esophageal Basaloid Squamous Carcinoma and Cancer of the Base of Tongue.
Joo Hoon KIM ; Ji Eun PARK ; Ji Hyun NAM ; Hyun Jung LIM ; Ji Yeon KIM ; Seun Ja PARK ; Min Jung JUNG ; Hee Kyung JANG ; Kang Dea LEE
Korean Journal of Gastrointestinal Endoscopy 2005;31(6):383-386
Basaloid squamous cell carcinoma occurs in various organs including the upper respiratory tract, the base of the tongue, pharynx, larynx, breast, uterine cervix and anus. It is a rare tumor, but it must be distinguished from other malignancies because of its aggressive clinical behavior. Many cases present in the advanced stage at the time of diagnosis. We present here a case of esophageal basaloid squamous cancer that was diagnosed in 75-year-old male patient who had dysphagia and throat pain, and this was accompanied by squamous cell cancer of the tongue base, as was determined by laryngoscopic and esophagogastroscopic examination.
Aged
;
Anal Canal
;
Breast
;
Carcinoma, Squamous Cell*
;
Cervix Uteri
;
Deglutition Disorders
;
Diagnosis
;
Esophagus
;
Female
;
Head and Neck Neoplasms
;
Humans
;
Larynx
;
Male
;
Neoplasms, Squamous Cell
;
Pharynx
;
Respiratory System
;
Tongue*
7.Extracorporeal Shock Wave Therapy for Calcific Tendinitis of the Shoulder.
Sung Il SHIN ; Kyung Won SONG ; Jin Young LEE ; Seung Yong LEE ; Gab Rae KIM ; Hee Chun KIM ; Dea Eun CHOI
The Journal of the Korean Orthopaedic Association 2006;41(5):865-870
PURPOSE: To evaluate whether Extracorporeal Shock Wave Therapy (ESWT) is an effective treatment without side effects for chronically painful calcifying tendinitis. MATERIALS AND METHODS: Study subjects were 72 patients (17 males and 55 females) aged 37-64 years, with a mean of 48, showing chronic, symptomatic, calcifying tendinitis of the shoulder refractory to other conventional conservative therapies. Calcifications were type I or type II according to the classification of Gartner, and with a minimum diameter of 10 mm. Patients with type 3 calcific tendinitis were excluded, because this type has a strong tendency to spontaneous resolution. Extracorporeal shock wave therapy comprised one or two treatments, each consisting of 800 shocks, with a frequency of 120 impulse per minute and the energy density of 0.14 mJ/mm2. We assessed the presence and size of calcified deposits at 1, 3, 6 and 12 months by conventional radiography. All patients also underwent clinical examination, and the Constant (and Murley) score and pain were calculated. The intensity of pain was measured with the visual analogue scale (VAS) from 0 to 10 points, where 0 represents the absence of pain and 10 unbearable pain. RESULTS: One month after the treatment, complete resorption of the calcium deposits was observed in 19 patients (26%), partial resorption was observed in 26 patients (36%), and no modification in the calcium deposits was observed in 27 patients (38%). At six months the complete disappearance of the calcium deposits was noted in 42 patients (68%), but in the 10 patients (14%), calcium deposit appeared unchanged. This result is remained unvaried after 6 month follow-up. Using the Constant and Murley score, this study showed a significant decrease in pain and a significant increase in shoulder function (p<0.001). At six months, 76% of the patients presented satisfactory functional result. About 15% reported a subjective and objective recovery, and only 6 patients (8%), classified as poor result but in our series no differences were found between results at 6 month and 12 month follow-up. At 12 month follow-up there were differences in the Constant score between treated shoulder and contralateral side, respectively 77.6 (59-91) and 87.2 (74-96), but not significant. There were no side effects. CONCLUSION: ESWT is an effective treatment without side effects and an alternative therapy for chronically painful calcifying tendinitis of the shoulder refractory to conventional therapies.
Calcium
;
Classification
;
Follow-Up Studies
;
Humans
;
Male
;
Radiography
;
Shock*
;
Shoulder*
;
Tendinopathy*
8.The Role of BF-7 on Enhancement of Memory and Cognitive Funtion.
Dea Kyung KIM ; Jun Young LEE ; Jung Jun SUNG ; Eui Tae KIM ; Yong Sik KIM ; Oh Sang KWON ; Young Chul YUN ; Tae Jin LEE ; Yong Koo KANG ; Yoon Hee CHUNG ; Sung Su KIM ; Kyung Yong KIM ; Won Bok LEE
Korean Journal of Anatomy 2004;37(6):519-527
Various factors such as senescence, stress, neurodegenerative diseases including Alzheimer's disease (AD) contribute to the impairments of organs, especially brain. Also, they should be negative factors on normal brain function, like as memory and cognition. In this study, the neuroprotective role of BF-7, extracted from Bombyx mori, was examined agaist scopolamine-induced neurotoxicity in SK-N-SH cells. In order to know if the BF-7 has positive role on the cognition and memory, we examined using SD rat model and human. Scopolamine-induced memory impairments were observed, as measured by the passive avoidance and water maze tests, but treatment with BF-7 significantly improved memory and cognitive function. Moreover, the memory index and memory preservation of clinical experiments using MMSE-K tests were significantly improved memory and cognitive function. This results strongly represent that the BF-7 play effectively positive role in the improvement of brain function including learning and memory. Taken together, our results suggested that the BF-7 should be useful for developing strategies protecting nervous system and improving brain function.
Aging
;
Alzheimer Disease
;
Bombyx
;
Brain
;
Cognition
;
Humans
;
Learning
;
Memory*
;
Models, Animal
;
Nervous System
;
Neurodegenerative Diseases
;
Scopolamine Hydrobromide
9.The Activation of ERK1/2 Via Tyrosine Kinase Pathway Attenuates TRAIL-induced Apoptosis in HeLa cell.
Yoo Hun NOH ; Myoung Woo LEE ; Dea Sung KIM ; Do Yeon LEE ; Sug Won KIM ; Yong Koo KANG ; Dong Seup SOHN ; Soon Cheol PARK ; Yoon Hee CHUNG ; Kyung Yong KIM ; Sung Su KIM ; Won Bok LEE
Korean Journal of Physical Anthropology 2004;17(3):187-196
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) serves as an extracellular signal triggering apoptosis in tumor cells. To characterize the molecular events involved in TRAIL-induced apoptotic signaling, we investigated the role of extracellular signal-regulated kinase 1/2(ERK1/2) in the apoptosis using HeLa cells. Here we show that TRAIL pronounced ERK1/2 activation through a tyrosine kinase-dependent mechanism, subsequently elevated anti-apoptotic Bcl-2 protein levels. Pretreatment with Genistein, an inhibitor of tyrosine kinase, significantly attenuated ERK1/2 activation and enhanced cell death. Moreover, inhibition of ERK1/2 with PD98059 promoted apoptotic cell death through the down-regulation of ERK1/2 activity and Bcl-2 protein levels. Taken together, our results suggest that the activation of ERK1/2 via tyrosine kinase pathway plays a protective role as the mechanism of cellular defense through the up-regulation of Bcl-2 protein levels in TRAIL-induced apoptosis.
Apoptosis*
;
Cell Death
;
Down-Regulation
;
Genistein
;
HeLa Cells*
;
Humans
;
Necrosis
;
Phosphotransferases
;
Protein-Tyrosine Kinases*
;
Tyrosine*
;
Up-Regulation
10.Human metapneumovirus infection in Korean children.
Hee Hyun YEOM ; Joon Soo PARK ; Dong Jun JEONG ; Chang Jin KIM ; Yong Bae KIM ; Dea Hoon LEE ; Kyung Joong KIM ; Jong Yoon CHUN ; Chun KANG ; Yoon Seok CHUNG ; Hyang Min CHEONG
Korean Journal of Pediatrics 2006;49(4):401-409
PURPOSE: Human metapneumovirus(hMPV) is a respiratory viral pathogen that causes a wide spectrum of illnesses, ranging from asymptomatic infection to severe bronchiolitis. The virus has been identified world widely, but so far it has not been published in Korea. METHODS: We obtained clinical samples by nasopharyngeal aspiration from 218 children hospitalized due to acute lower respiratory tract infections at Soonchunhyang University Hospital in Cheonan from October, 2004 to April, 2005. We designed specific primers from conserved region of fusion glycoprotein of hMPV. Total RNA was extracted and RT-PCR was performed, and single specific 423 bp product was obtained. The PCR product was confirmed to be fusion glycoprotein RNA by sequencing. RESULTS: We detected hMPV in 15(6.9 percent) of the 218 hospitalized children. The infected children comprised nine boys and six girls; their mean age was 2.8 years(5 mo-12 yrs) and they were diagnosed with pneumonia(60 percent), bronchiolitis(33.3 percent), croup(6.6 percent). The number of cases of detected hMPV in Korea increased dramatically during the period from March to May 2005. CONCLUSION: hMPV is circulating in Korean children and is associated with respiratory tract infection. Additional studies are required to define the epidemiology and the extent of diseases in the general population caused by hMPV.
Asymptomatic Infections
;
Bronchiolitis
;
Child*
;
Child, Hospitalized
;
Chungcheongnam-do
;
Epidemiology
;
Female
;
Glycoproteins
;
Humans*
;
Korea
;
Metapneumovirus*
;
Polymerase Chain Reaction
;
Respiratory Tract Infections
;
RNA