OBJECTIVETo study the effect of iodine supplementation on infant mortality and growth in Xinjiang.

METHODSUrine iodine, height and head circumference (HC) of children aged 5 years in two townships was measured before and yearly after iodine supplementation of irrigation water. Height and HC were expressed as Z scores (United States children used as the reference group). Neonatal and infant mortality rates were obtained from official records in three counties from 1988 to 1999, and analyzed by a logistic regression model.

RESULTSThe odds ratio of infant mortality decreased 56.49% and neonatal mortality 65.71% respectively after iodination; there was no significant difference in the odds ratio of infant or neonatal mortality between experimental and control areas without iodination. In Langru township, the mean height of 5 year-old children increased from 95 cm in 1992 to 106.9 cm in 1998 - 1999, and HC from 48.4 cm to 50.5 cm. Median urine iodine increased from <10 to 176 micro g/L. In Bakechi township, mean height increased from 91 cm in 1993 to 106.5 cm in 1998 - 1999, HC from 48.7 to 49.6 cm, and median urine iodine from 39 to 138 micro g/L.

CONCLUSIONIn Xinjiang, adequate iodine treatment markedly decreased infant and neonatal mortality, and largely preventing stunting of height and HC in children.

Adolescent ; Adult ; Animals ; Body Height ; drug effects ; Child ; Child Development ; drug effects ; Child, Preschool ; Female ; Humans ; Infant ; Infant Mortality ; trends ; Iodine ; analysis ; pharmacology ; urine ; Logistic Models ; Male ; Odds Ratio ; Plants ; chemistry ; Soil ; analysis ; Thyroid Gland ; chemistry ; Time Factors ; Water ; chemistry