With the development of modem technology,more and more plastic products are widely used in various fields,while bringing significant convenience to the society,it also leads to more and more environmental estrogen.The influence of plasticizer is increasing,especially on the development of children.Extensive contacting with plasticizer is considered to be closely related with gonadal digenesis,obesity and other problems in children.This review focuses on the latest research results about the basic and clinical experiments of Di (2-ethylhexyl) phthalate (DEHP),which illuminate the effects of DEHP on children's growth and metabolism,and lay foundations for rational clinical intervention and scientific plasticizer's application.

Adrenergic beta-2 Receptor Agonists ; administration & dosage ; therapeutic use ; Asthma ; diagnosis ; etiology ; therapy ; Child ; Child, Preschool ; Chronic Disease ; Glucocorticoids ; administration & dosage ; therapeutic use ; Humans ; Infant ; Pediatrics ; Seasons ; Time Factors

0.5,the variance 0.5,variance coefficient

Amphotericin B ; administration & dosage ; therapeutic use ; Antifungal Agents ; administration & dosage ; therapeutic use ; Child ; Child, Preschool ; Fluconazole ; administration & dosage ; therapeutic use ; Humans ; Mycoses ; drug therapy ; epidemiology ; prevention & control ; Practice Guidelines as Topic ; standards

One case of Klinefelter syndrome with complicated 46,XY/47,XXY/48,XXXXY and metabolic syndrome was reported.

Objective To explore the effects of various dosage and multiple course of Dexamethasone(DEX) on the expressions of WNTs,?-catenin and glycogen synthase kmase-3?(GSK-3?) genes in the lung of premature rats on the 19th day of embryo.Methods Twelve pregnant SD rats were divided into 3 groups randomly:small dose DEX group,large dose DEX group and control group with 4 rats in each group.The rats in control group were injected with saline 9 g/L;rats in small dose DEX group were injected with DEX 0.4 mg/(kg?d),and the rats in large dose DEX group were injected with DEX 0.8 mg/(kg?d) after DEX was diluted to 0.5 mL with saline.On the 19th day of gestation,fetuses were surgically taken out.The reverse transcription polymerase chain reaction PCR method was used to detect expressions of WNT7b,WNT5a,WNT2,GSK-3? and ?-catenin genes mRNA.Results The expressions of WNT7b(0.55?0.19,0.64?0.54)and ?-catenin(2.03?0.58,2.40?0.89)genes mRNA in small dose DEX group and large dose DEX group were significantly higher than those of control group(WNT7b:0.18?0.10,?-catenin:1.77?0.54)(Pa

Phosphatase and tensin homologue deleted on chromosome 10(PTEN) is a tumor suppressor which can inhibit proliferation and migration and control apoptosis in a number of cell types,mainly through inhibiting the phosphoinositide 3-kinase(PI3K) signaling pathway.A number of in vitro and in vivo studies has been instrumental in uncovering a direct correlation between deregulated PTEN/PI3K signaling and changes in neuronal morphogenesis,which is likely to have profound bearings upon the pathogenesis of neurological symptoms.This review outlines recent work on the function of PTEN during the formation and maintenance of neuronal circuits in the brain.

Antitubercular Agents ; therapeutic use ; Child ; Child, Preschool ; Diagnostic Errors ; Female ; Fever ; etiology ; Humans ; Infant ; Male ; Pediatrics ; Tuberculosis ; drug therapy ; microbiology ; physiopathology ; X-Ray Film

Objective: To probe the curative effect evaluation method of traditional Chinese medicine in treating pediatrics virus pneumonia.Methods: On the basis of the outcome of analysis made on the preceding three turns of experts' questonnaires,the fourth turn of questionnaires was prepared to investigate the curative effect evaluation method of traditional Chinese medicine in treating pediatrics viral pneumonia.They were distributed to 30 experts in this field all over the country.The questionnaires were analyzed with the method of Delphi Measurement.Results: Chest X ray,cough,temperature,lung auscultation and so on were very important in disease curative effect evaluation,the ratio of full score higher than 0.95 and the coefficient of variation less than 0.24;cough,lung auscultation,Chest X ray and so on were main components in the syndrome and the ratio of full score and the coefficient of variation were respectively more than 0.90 and less than 0.34;dyspnea with rapid and short breath,lung auscultation and Chest X ray were main final result index and the ratio of full score and the coefficient of variation was respectively 1 and 0.Conclusion: Chest X ray,symptoms,temperature and lung auscultation were very important in disease curative effect evaluation;cough,lung auscultation and Chest X ray were main components in the syndrome;dyspnea with rapid and short breath,lung auscultation and Chest X ray were main final result index.