4.Aggressive lymphoma.
Chinese Journal of Hematology 2013;34(2):177-177
5.Comparison of the therapeutic effects of high-dose chemotherapy and autologous stem cell transplantation in T cell lymphoma.
Ying WANG ; De-pei WU ; Xiao-jin WU
Chinese Journal of Oncology 2010;32(4):298-299
Adolescent
;
Adult
;
Aged
;
Antineoplastic Combined Chemotherapy Protocols
;
therapeutic use
;
Child
;
Cyclophosphamide
;
therapeutic use
;
Dexamethasone
;
therapeutic use
;
Disease-Free Survival
;
Doxorubicin
;
therapeutic use
;
Female
;
Follow-Up Studies
;
Hematopoietic Stem Cell Transplantation
;
Humans
;
L-Lactate Dehydrogenase
;
blood
;
Lymphoma, T-Cell
;
blood
;
drug therapy
;
therapy
;
Male
;
Middle Aged
;
Neoplasm Recurrence, Local
;
Remission Induction
;
Retrospective Studies
;
Survival Rate
;
Transplantation, Autologous
;
Vincristine
;
therapeutic use
;
Young Adult
9.Chronic graft versus host disease related polymyositis:a case report and literature review
Shengli XUE ; De-Pei WU ; Ai-Ning SUN ;
Chinese Journal of Organ Transplantation 2005;0(11):-
Objective To summarize the diagnostic and therapeutic experience of a patient with chronic graft versus host disease (cGVHD) related polymyositis (PM) after allogeneic hematopoietic stem cell transplantation (allo-HSCT).Methods A patient with acute lymphocytic leukemia in com- plete remission received sibling allo-HSCT,and cyclosporine and methotrexate were adopted to pre- vent GVHD.Results Eleven days after HSCT,WBC>0.5?10~9/L,13 days after HSCT,PLT>20?10~9/L;27 days after HSCT,chromosome analysis of bone marrow cells showed 99% donor type. Seventeen days after HSCT,Ⅰ~0 acute GVHD of skin occurred,and it was cured by intravenous injec- tion of dexamethasone and methotrexate.Eight months after HSCT,cGVHD of liver happened.Al- though treated by tacrolimus and azathioprine,enzymes of liver were still elevated.At last,tacrolimus combined with sirolimus were used,and enzymes of liver subsided gradually.However,the serum creatine phosphokinase (CK) began to rise from 9 U/L to 3010 U/L,and fatigue all over the patient occurred.Finally,the symptom relapsed,and disability involved with the origin of limbs appeared. The electromyogram and magnetic resonance imaging of concerned muscles confirmed the PM diagno- sis.Although treated with methylprednisolone and plasma exchange,the patient died due to asphyxia, while the CK as high as 21 010 U/L.Conclusion PM is a rare kind of manifestations of cGVHD. When the key muscle tissue was involved,the prognosis is poor.
10.Study of interaction between NS3 serine protease of HCV and wild type P53
Wu, OU ; E-De, QIN ; Cui-hong, YANG ; Pei-ying, YANG ; Man, YU
Bulletin of The Academy of Military Medical Sciences 2001;25(1):21-23
Objective:To investigate the molecular interaction between non-structural protein 3 serine protease of hepatitis C virus(HCV)and wild type P53,and to lay the basis for elucidating the mechanism of oncogenesis of hepatocellular carcinoma(HCC)after infection of HCV.Methods:The recombinant plasmids,pGAD424-NS3,pGAD424-NS315aa- and pGAD424-NS330aa-,were constructed and the interaction between NS3 serine protease and its cofactor NS4A,the interaction between wild type P53 and NS3 serine protease and its N-truncated mutants were dectected qualitatively and quantitatively in yeast two-hybrid system.Results:The results indicated that interaction existed not only between full-length NS3 serine protease and P53,but also between N-truncated mutants of NS3 serine protease and P53.Furthermore,the difference between enzyme activity unit(IU)of β-gal induced by these interactions was not significant(P>0.05).Conclusions:NS3 serine protease of hepatitis C virus and its N-truncated mutants can interact with wild type P53,and the region of NS3 serine protease involved in the interaction may be located in its C-terminal,but not in its N-terminal.