Leptin,the product of the obese gene,is a 16kDa secreted protein produced by white adipocytes.Because of its dual nature as a hormone and cytokine,leptin plays a role in regulating energy metabolism,inflam-marion,immune response,neuroendocrine and angiogenesis,and so on.The review focuses on the research and controversy of leptin's effect in osteoarthritis.

Humans ; Occupational Health Services ; standards

Animals ; Antibodies, Viral ; analysis ; immunology ; Hemorrhagic Fever with Renal Syndrome ; diagnosis ; immunology ; prevention & control ; Humans ; Periodicals as Topic ; Vaccination

China ; Humans ; Occupational Health ; legislation & jurisprudence ; Public Health ; legislation & jurisprudence ; Public Health Administration ; legislation & jurisprudence

Dental Implantation, Endosseous ; Humans ; Tooth Socket ; surgery

0.5,the variance 0.5,variance coefficient

Cytokines ; metabolism ; Humans ; Interleukins ; metabolism ; Lung ; metabolism ; pathology ; Pneumoconiosis ; etiology ; metabolism ; Receptors, Platelet-Derived Growth Factor ; metabolism ; Transforming Growth Factor beta ; metabolism ; Tumor Necrosis Factor-alpha ; metabolism

Recent studies have revealed that tumor suppressor PTEN does not only closely relate to the development and differentiation of brain but also get extensively involved into the pathophysiological processes of ischemic brain injury.Through research on the mechanisms of molecular regulation mediated by PTEN in ischemic brain injury will provide new perspectives for the treatment of ischemic brain injury.