1.Effect of anti-oxidation function of Panax japonicus saponins on mice' hypoxia/reoxygenation injury.
De-Jian WEN ; Song ZHANG ; Cui-Lan ZHANG
Chinese Journal of Applied Physiology 2008;24(3):318-319
Animals
;
Antioxidants
;
pharmacology
;
Female
;
Hypoxia
;
physiopathology
;
Male
;
Mice
;
Panax
;
chemistry
;
Random Allocation
;
Reperfusion Injury
;
prevention & control
;
Saponins
;
isolation & purification
;
pharmacology
2.Observation of anti-oxidation effect of total Panax japonicus saponins on cerebral ischemia/reperfusion injury in rats.
De-Jian WEN ; Song ZHANG ; Cui-Lan ZHANG
Chinese Journal of Applied Physiology 2008;24(2):195-228
Animals
;
Antioxidants
;
pharmacology
;
Brain
;
metabolism
;
Brain Ischemia
;
metabolism
;
Male
;
Malondialdehyde
;
metabolism
;
Panax
;
Rats
;
Rats, Sprague-Dawley
;
Reperfusion Injury
;
metabolism
;
Saponins
;
pharmacology
;
Superoxide Dismutase
;
metabolism
4.Changes of NO and NOS in blood and SaO2 of acclimatized youngs pre- and post-oxygen-enrichment at 3700 m.
Xi-zhou ZHANG ; Jian-hua CUI ; Zhen-de HA
Chinese Journal of Applied Physiology 2004;20(2):149-150
Acclimatization
;
physiology
;
Adolescent
;
Altitude
;
Humans
;
Male
;
Nitric Oxide
;
blood
;
Nitric Oxide Synthase
;
blood
;
Oxygen
;
physiology
;
Pulmonary Gas Exchange
;
Young Adult
5.Changes of plasma prethrombotic state molecular markers levels in silicosis patients.
De-Zhong ZHANG ; Jian-Yan WEN ; Li-Min FAN
Chinese Journal of Industrial Hygiene and Occupational Diseases 2009;27(7):444-446
Adult
;
Biomarkers
;
blood
;
Blood Proteins
;
metabolism
;
Humans
;
Male
;
Middle Aged
;
Silicosis
;
blood
7.Study and application about a modality preventing iodine deficiency disorders in coastal salt-produced areas
Long, DAI ; De-fa, LIU ; Ya-ping, ZHANG ; Hui-jian, SU ; Yan-feng, ZHANG
Chinese Journal of Endemiology 2008;27(5):570-573
Objective To discuss the strategy and intervention measures of the iodine deficiency disorders (IDD)control in coastal salt.producing areas so as to shoot the problem of non-iodized salt causing IDD.Methods Accordinng to different areas,periods and crowds,eomplicatd measures and strategies were taken such as supply of iodized salt to peopie in special need while universalizaion of iodized salt,health promotion,private salt factory censu8 and close.iodized salt quality monitoring and promotion of technology of iodized salt producion in Xiamen, where the probiem of non-iodized salt Was serious since 1995.Results Iodized salt manufactured Was qualified in a increased rate from 89.50% in 1995 to 96.17% in 1997,stablized at 99.00%since 2000.Qualified iodized salt sold in the shops waft increased from 87.33%in 1996 to 96.33%in 1998.Popularization covered by iodized salt in urban areas increaased from 0.92%in 1 995 to 100.00%in 2000,and it Was increased from 0 to 99.00%in suburban area8 and increased from 0 to 89.00%in rural areas.Since 2001 iodized salt covered up 93.00%of the people.The rate of child goitre in urban,suburban and rural areas respectively Wag 16.44%(228/1387), 20.57%(266/1293) and 24.93%(651/2611).Moreover,beginning from 1996,it reduced tO below of 5.00%respectively in 1999,2001 and 2005.The median of urinary iodine of children in urban,suburban and rural areas respectively was 137.50, 102.12,94.66 μg/L in 1995,since 1997 it reached 100.00μg/L and kept at 120.00μg/L In 2007 the median of urinarv iedine of children respectively was 271.10,240.40,198.10μg/L in urban,suburban and rural areas.The pereentage of awareness of IDD knowledge was 74.00%(444/600)in students in 1997 and reached 95.00% since 2000.Conclusion The paRern of eliminating iodine deficiency dis ease in Xiamen has successful established,which works efficiently and sets an example for iodized salt supplement in non-iodized salt areas and continually eliminating the iodine deficiency disease.
8.The clinical and experimental study of thalidomide in the treatment of ankylosing spondylitis
Feng HUANG ; Jieruo GU ; Wei ZHAO ; Jian ZHU ; Jianglin ZHANG ; De′En YU ;
Chinese Journal of Rheumatology 2001;0(05):-
20% improvement in 4/7 primary indices.Sharp declines in several parameters were noticed during 3 to 6 months.Pain in 9 patients disappeared.There was also a statistically significant decrease in TNF ? transcripts in the PBMC.Conclusion Thalidomide is a reasonably promising drug for treating resistant ankylosing spondylitis and its biological mechanism is related to the gene expression suppression of proinflammatory cytokine TNF ?.
9.Pregnancy outcomes of 194 couples with balanced translocations
Yue-Ping ZHANG ; Jian-Zhong XU ; Min YIN ; Mei-Fang CHEN ; De-Lin REN ;
Chinese Journal of Obstetrics and Gynecology 2000;0(09):-
Objective To investigate the pregnancy outcomes of couples with either maternal or paternal balanced translocations.Methods One hundred and ninety-four couples were divided into three groups based on the kind of translocations:135 with reciprocal translocation,52 with nonhomologous Robertsonian translocations,and 7 with homologous Robertsonian translocations.Past reproductive histories were surveyed.For those who wanted to have their own babies by natural conceptions after knowing their karyotypes as well as the risks of abnormal offsprings,subsequent pregnancy outcomes were recorded.Total pregnancy outcomes were compared between three groups.Results(1)503 previous and subsequent pregnancies were recorded in detail.The pregnancy outcomes are as follows:spontaneous abortions 81.7% (411/503);induced terminations because of fetal abnormalities 3.2%(16/503);birth defects 7.2% (36/503);normal/balanced offsprings 8.0%(40/503).In reciprocal translocations,nonhomologous Robertsonian translocations and homologous Robertsonian translocations,the birth defects rates were 5.7% (20/350),10.9%(14/128)and 8.0%(2/25),respectively(P
10.The effect of endostatin mediated by adenovirus on the inflammation and cytokines of arthritis rats
De-Qian MENG ; Yu ZHANG ; Wei-Gan SHEN ; Yong-Ji XUE ; Li-Chun XU ; Jian GU ;
Chinese Journal of Rheumatology 2003;0(12):-
Objective To investigate the effect of recombinant adenovirus mediatied human endostatin (rAD-GFP-ES)on rats with collagen typeⅡinduced arthritis(CIA),and explore the mechanism of inflamma- tion and cytokines inhibition on rats CIA.Methods The rAD-GFP-ES was amplified and purified.The model of rat CIA was induced by intradermal injection of typeⅡcollagen combined with complete Freund's adjuvant(CFA). On the second day after the injection,the therapeutic administration of rAD-GFP-ES(1?10~(11)pfu?kg~(-1)?week~(-1)?4 weeks)were performed to the rats.The mean arthritis index(AI)was scored every week since then.The relative concentrations of ES,IL-I?,TNF-?in sera collected at the fourth week were evaluated by western blotting. Results①The titer of the purified rAD-GFP-ES and rAD-GFP was 6.6?10~(12)pfu/ml and 4.8?10~(12)pfu/ml,re- spectively(A_(260nm)/A_(280nm)>1.3).②The concentration of ES in sera of the group treated with rAD-GFP-ES was 2.4-lold higher compared to the normal group.③The mean arthritis index of the group treated with rAD-GFP- ES was much lower than that of the model group.The administration of rAD-GFP-ES could significantly de- creas the production of IL-1?and TNF-?in sera.Conclusions①The rAD-GFP-ES is efficiently expressed in vivo.②The rAD-GFP-ES has an inhibitory effect on the arthritis index of rat CIA.③IL-1?and TNF-?are involved in the pathogenesis of RA.The rAD-GFP-ES has an inhibitory effect on the expression of IL-1?and TNF-?in rat CIA.