1.Research progress in cancer genomics.
Chinese Journal of Oncology 2006;28(7):555-557
3.Genetic analysis of complex diseases: status quo and prospects.
Acta Academiae Medicinae Sinicae 2009;31(6):661-663
This review comments the status quo, especially the major problems, of the genetic analysis of the complex diseases, provides some possible solutions, and explores the further development trends in this field.
Genetic Testing
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Humans
4.New trends in research on cancer genomics.
Chinese Journal of Oncology 2007;29(7):544-544
DNA Methylation
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DNA, Neoplasm
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genetics
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Genomics
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trends
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Human Genome Project
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Humans
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Neoplasms
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genetics
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Research
5.Peroxisome proliferator activated receptor gamma Pro12Ala: old topic of conversation and new question.
Acta Academiae Medicinae Sinicae 2011;33(6):591-592
Comments concerning Meta analysis for relationship between peroxisome proliferator activated receptor gamma Pro12Ala polymorphism and type 2 diabetes susceptibility in different cohorts in this mini review were given. The comments pointed out existent problems and presented suggestions for genetic analysis of diseases in Chinese populations.
Asian Continental Ancestry Group
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genetics
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Diabetes Mellitus, Type 2
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genetics
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Genetic Predisposition to Disease
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Humans
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PPAR gamma
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genetics
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Polymorphism, Genetic
7.Effects of FKBP12.6 gene transfection on the contractility of ventricular myocytes of rats with heart failure
De LI ; Wei WU ; Chang FANG
Medical Journal of Chinese People's Liberation Army 2001;0(09):-
Objective To investigate the effects of FKBP12.6 gene transfection on the contractility of ventricular myocytes of rats with heart failure.Methods Rat model of heart failure was established by a surgical operation of abdominal aortic stenosis.The enzymatic hydrolysis was employed to isolate the rats' ventricular myocytes.Mediated by adenovirus the FKBP12.6 gene was transfected into ventricular myocytes.Ad-GFP infected cardiac myocytes from heart failure rats and normal rats were used as control.Western blotting and reverse transcriptase-polymerase chain reaction(RT-PCR) were used to detect the specific overexpression of FKBP12.6.Transfected ventricular myocytes were loaded with the membrane-permeant Ca2+ dye X-rhod-1-AM.Under the condition of field stimulation,the laser confocal microscope in line-scan and plane-scan mode was used to detect the Ca2+ transients and myocytes contraction.Results The mRNA and protein levels of FKBP12.6 in the myocytes of rats with heart failure were significantly lower than that in normal myocytes(0.47?0.08 vs 0.96?0.12,0.25?0.04 vs 0.48?0.07,P
8.ACEI Combined with Astragalus Treat Early Diabetic Nephropathy(DN) 108 Cases
Fang LI ; De GAO ; Baoren WANG
Journal of Zhejiang Chinese Medical University 2007;0(01):-
[Objective] To discuss effective method for early DN.[Method] On the base of routine treatment,the treatment group 56 cases were added with Astragalus Injection;the control one 52 only routine therapy.[Result] In treatment group,41 had marked effect,14 had effect,1 had no effect,total effective rate was 98.2%;they were 14,23,15 and 71.1% respectively for control one.There’s obvious difference of meaning on effective rates(P
9.Prognostic significance of immune cells in tumor microenvironment.
Chinese Journal of Pathology 2008;37(10):700-703
Environment
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Female
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Humans
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Immunity
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immunology
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Male
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Neoplasms
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diagnosis
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immunology
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Prognosis
10.Clinical Observation of the Efficacy of Alprostadil in Reducing 24-hour-output of Urinary Albumin in Diabetic Patients with Cerebral Infarction
De CAI ; Wenzhen HE ; Yushan FANG
China Pharmacy 1991;0(05):-
OBJECTIVE:To observe the effect of Alprostadil in reducing24-hour-output of urinary albumin in diabetic patients with cerebral infarction.METHODS:56cases of diabetic patients with cerebral infaraction were randomly divided into treatment group(30cases)and control group(26cases);the control group were given the routine treatment,i.e.compound Danshen and Shengmai,for the treatment group,besides the routine treatment as stated in the control group,were given20?g Alprostadil that dispensed in100ml normal saline(NS)by intravenous drip,qd,for15days and then evaluated ef?fect.RESULTS:The therapeutic effect of the treatment group is better than that of the control group.Compared with that before treatment and that of the control group after treatment,the treatment group showed a lower level of24-hour-output of urinary albumin after treatment(P