1.Influence of Taurine Supplementation on Ultrastructure of Islet ? Cells in Neonatal Rats with Low Birth Weight
ke, YUAN ; zong-de, XIE ; jin-tao, HU ; wen, LI
Journal of Applied Clinical Pediatrics 2006;0(14):-
Objective To observe the influence of taurine supplementation during early postnatal life on body weight and ultrastructure of islet ? cells in neonatal rats with low birth weight(LBW).Methods LBW neonatal rats were made by feeding 20%(C group) or 10%(R group) protein diet to fetal rats during gestation and lactation.Half of femal rats in group R were given a supplementation with 2.5% taurine drinking water(RT group) only during lactation,while other femal rats freely drunk.At postnatal day 1 and 21,the neonatal rats were weighted and their pancreas were removed.The ultrastructural changes of ? cells were observed by electron microscopy.Results At postnatal 21 days,the body weight of offsprings in group RT was significantly highter than that in group R(P=0.003);and the ultrastructure of ? cells in group RT got more improvement than that in group R.Conclusion Taurine supplementation can improve the growth-catch-up and the ultrastructure of islet ? cells of neonateal rats with LBW.
2.Current sharing status of medical data in Hunan Province and its restrictive factors and countermeasures
Ye WANG ; De-Hua HU ; Qing-Yuan HU
Chinese Journal of Medical Library and Information Science 2018;27(2):13-19
The current sharing of medical data and its restrictive factors were surveyed by literature and question-naire investigation and analyzed with statistical analysis tools such as SPSS and Excel, which showed the influence of different restrictive factors on different populations. Certain measures were put forward for speeding up the sha-ring of scientific data, improving the medical treatment and academic level, strengthening the competitive power of hospitals and higher education institutions in Hunan Province.
3.Anterior small-incision focus debridement with posterior internal fixation for the treatment of lumbar spinal tuberculosis.
Xiao-zhang YING ; Qi ZHENG ; Shi-yuan SHI ; Yi-fan WANG ; Jun FEI ; Gui-he HAN ; De-xin HU
China Journal of Orthopaedics and Traumatology 2016;29(6):517-521
OBJECTIVETo explore clinical outcomes and advantages of anterior small-incision focus debridement with posterior internal fixation through muscle spa ring in treating patients with lumbar spinal tuberculosis.
METHODSFrom February 2010 to February 2014, totally 82 patients with lumbar spinal tuberculosis were treated by posterior individual fixation with small-incision focus debridement,including 50 males and 32 females with an average of 50.5 years old. All patients were divided into two groups according to different procedures. Forty-nine patients in group A were treated with anterior small-incision focus debridement with posterior internal fixation through muscle spa ring at stage I ; and 33 patients in group B were treated with focus debridement with posterior internal fixation by extraperitoneal approach at stage I . Postoperative mechanical ventilation time, preoperative and postoperative Cobb angle, visual analogue scale (VAS), erythrocyte sedimentation rate (ESR) and Frankel grading were observed and compared. Postoperative complications, stability of internal fixation and bone union were compared.
RESULTSAll patients were followed-up from 15 to 36 months with an average of 23.7 months. Psoas abscess of three patients in group A and 1 patient in group B on the opposite side increased and were healed by the secondary apocenosis. The other 78 cases were healed at stage I, and no sinus tract formation, incisional hernia, leakage of cerebrospinal and occurrence of spinal tuberculosis were occurred. Fracture healing time ranged from 3 to 7 months with an average of 4.6 months. Postoperative mechanical ventilation time and VAS score in group A was better than group B. There were no statistical differences in Cobb angle, ESR and Frankel grading at the final following-up between two groups.
CONCLUSIONAnterior small-incision focus debridement with posterior internal fixation through muscle spa ring in treating patients with lumbar spinal according to degree of damage is a safe and effective method.
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Debridement ; methods ; Female ; Fracture Fixation, Internal ; Humans ; Male ; Middle Aged ; Minimally Invasive Surgical Procedures ; methods ; Treatment Outcome ; Tuberculosis, Spinal ; surgery ; Young Adult
4.Application of cell block technology in pathologic diagnosis of hematolymphiod neoplasms.
Yuan SHI ; Qin HU ; Yang ZHOU ; Ying-yong HOU ; Lu-de SUN ; Hong-xian XIE ; Akesu SUJIE ; Yun-shan TAN
Chinese Journal of Pathology 2010;39(8):553-554
Adolescent
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Adult
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Aged
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Aged, 80 and over
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Ascites
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pathology
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Biopsy
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Biopsy, Fine-Needle
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Child
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Cytodiagnosis
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methods
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Diagnosis, Differential
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Female
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Humans
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Leukemia-Lymphoma, Adult T-Cell
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pathology
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Lymphoma, B-Cell
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pathology
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Lymphoma, Large B-Cell, Diffuse
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pathology
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Lymphoma, T-Cell
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pathology
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Male
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Middle Aged
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Pleural Effusion
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pathology
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Young Adult
5.The expression of interferon-?in the peripheral blood and correlation with disease activity in systemic lupus erythematosus patients
Shan DENG ; Da-Wei HU ; Yuan WANG ; Nan SHEN ; Yue-Ying GU ; Chun-De BAO ; Shun-Le CHEN ;
Chinese Journal of Rheumatology 2003;0(11):-
Objective To investigate the mRNA and protein expression levels of interferon(IFN)-?in the peripheral blood of patients with systemic lupus erythematosus(SLE),to analyze the relationship between IFN-?and disease activity,and to evaluate the role of IFN-?in the pathogenesis of lupus.Methods SYBR green dyeⅠbased real-time quantatives PCR method was used to compare the mRNA expression levels of IFN-?in the peripheral blood leucocyte of SLE patients and healthy controls.Surum levels of IFN-?were measured with ELISA method.Results IFNA1 mRNA expression level in SLE patients(2.8?3.5)was signifi- cantly lower than that of normal controls(12.7?10.7,P=0.000).There was no significant difference between patients treated with glucocorticoid and those without in the expression level of IFNA1(P=0.549).Serum levels of IFN-?in SLE patients was significantly higher than that of normal controls(P=0.003).The SLEDAI score and anti-dsDNA antibody correlated positively,and complement components C3,C4 and leukocytes correlated negatively with serum concentration of IFN-?.IFN-?level correlated with the presence of fever and rash. Conclusion The close relationship between IFN-?serum level and disease activity in SLE patients suggests that IFN-?might be of importance in the disease process.
6.An improved method of quantitative assessment of regional cerebral blood flows by perfusion CT at the general infusion rate
Chun-Hong HU ; Qing-De WU ; Xue-Yuan WANG ; Wei ZHU ; Hai-Lin SHEN ; Yin-Di FU ; Yi DING ;
Chinese Journal of Radiology 2001;0(01):-
Objective To improve the conventional method of quantitative assessment of regional cerebral blood flows(rCBF)by a perfusion CT study based on maximal slope model at the general infusion rate(
7.Case Report of Peliosis Hepatic in Child and Its Literature Review
zhao-yuan, QIN ; shu-mei, CHEN ; rui-de, HU ; xiao-yun, JIANG ; mei-na, LIU ; zhen-yu, SHEN
Journal of Applied Clinical Pediatrics 2006;0(19):-
Objective To report a peliosis hepatic in child and review literature and discuss.Methods Case history was inquired.Physical,labtoratory,imagement and histopathology of liver biopsy(HE staining) were examed.Results A 4-year old girl appeared dermatitis with erythema and herpes at local skin where was bit by insect before onset.The girl appeared fever,cough,then abdominal pain,hepatomegaly,pleural effusion and ascites.Lab examination revealed slight elevation of aspartate transaminase,?-glutamyltranspeptidase and alkaline phosphatase.The liver B-mode ultrasonography and CT scan revealed hepatomegaly with density heterogeneity of the parenchyma.The liver biopsy revealed many small capsule filled with blood cells.Conclusions Clinical characteristics of the disease are fever,upper abdomen pain,janundice,ascites and hepatomegaly.The diagnosis shall be combined with the pathologic biopsy of liver.
8.Investigation of increasing efficacy of aterial infusion of NaHCO3 to solid malignant tumors in interventional chemotherapy
Ping-Sheng FAN ; Yu-Xiu WAN ; Ji-De LI ; Hu BEI ; Ke-Hai FENG ; Shi-Ceng WANG ; Xin-Min LI ; Ru-Hua LIU ; Li-Yuan HU ;
Chinese Journal of Clinical Pharmacology and Therapeutics 1999;0(04):-
Aim To observe the effect of interventional therapy of 5-fluorouracil(5-Fu), mitomycin C (MMC) and adriamycin (ADM) on solid malignant turmors in association with aterial infusion of NaHCO3.Methods Patients were randomly divided into two groups.With Seldinger technique,through the femoral atery to tumor atery.The patients in the control group were infused by anticarcinoma agents simply ,and patients in the treatment group were initially infused by NaHCO3,and then by NS 30 ml and anticarcinoma agents seperately. Results Partial remission (PR) in the group treated with NaHCO3 and anticarcinoma agents was significantly higher than in the group treated simply with anticarcinoma agents.Conclusion Aterial infusion of NaHCO3 into malignant tumors can increase the efficacy of ADM,MMC and 5-Fu.
9.Non-nucleoside reverse transcriptase inhibitors (Part 18): synthesis and anti-HIV activity of 4-allylamino or 4-azido substituted diaryltriazines.
Yuan-Zhen XIONG ; Hai-Rong HU ; Fen-Er CHEN ; Jan BALZARINI ; Christophe PANNECOUQUE ; Erik de CLERCQ
Acta Pharmaceutica Sinica 2009;44(2):145-149
Eight new diaryltriazine derivatives containing 4-allylamino and 4-azido substitutes guided by molecular docking have been designed and synthesized based on our previous work. The evaluation of HIV inhibitory activity demonstrated that all compounds were potent against HIV-1 replication. The most active compound 7c exhibited activity against HIV-1 (IC50 = 0.034 micromol x L(-1), SI = 6,475) and the double mutant strain (IC50 = 9.39 micromol x L(-1)) in the micromolar range, which was more potent than nevirapine.
Anti-HIV Agents
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chemical synthesis
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chemistry
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pharmacology
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Catalytic Domain
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HIV-1
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drug effects
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Inhibitory Concentration 50
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Molecular Structure
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Reverse Transcriptase Inhibitors
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chemical synthesis
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chemistry
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pharmacology
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Triazines
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chemical synthesis
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chemistry
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pharmacology
10.Correlation analysis of sub-health status and health-related risk behaviors in college students.
De-qin JIANG ; Rong-ying YAO ; Chang-jiang YUAN ; Lan HU
Journal of Southern Medical University 2011;31(1):61-64
OBJECTIVETo study the sub-health status in college students in relation to health-related risk behaviors.
METHODSUsing convenient sampling method, 6176 college students (3285 male and 2891 female students) were surveyed with questionnaires for general demographical data, sub-health state and health-risk behaviors.
RESULTSThe reported rate of sub-health state was 10.2%. The reported rate of physical sub-health was 11.7%, and the rate was 21.7%, 13.9% and 15.0% for inadequate physical activities, poor physical function and poor immunity, respectively. The reported rate of psychological sub-health was 10.5%, with a rate of 14.7%, 22.6% and 7.3% for emotional problems, behavioral problems and social adaptation difficulties, respectively. The risk factors for college students included insufficient sleeping, inadequate sport activities, missing breakfast, partial dietary, smoking and drinking (P<0.05).
CONCLUSIONThe reported rate of sub-health is rather high. Early intervention for health-related risk behaviors should be conducted to prevent the incidence of sub-health among college students.
Adult ; Female ; Health Behavior ; Health Status ; Humans ; Life Style ; Male ; Risk Reduction Behavior ; Students ; psychology ; Surveys and Questionnaires ; Universities ; Young Adult