Objective To detect the expression of Survivin ,PTEN and to discuss the correlations between them and the clinico-pathological characteristic of rectal carcinoma ,evaluate their effects on the development of rectal carcinoma .Methods SP immuno-histochemical was used to detect the expression level of Survivin and PTEN in 72 rectal carcinoma samples ,and randomly selected 20 cases of normal paraneoplastic tissues as control group .Results The positive rate of Survivin and PTEN in normal paraneoplas-tic tissues were 0 and 85 .0% respectively ;The positive rate in rectal carcinoma samples were 61 .1% and 41 .7% respectively .Posi-tive expressions of Survivin and PTEN did not had no correlation with gender ,age ,but correlated with differentiation ,dukes staging and lymph node metastasis .PTEN expression was negatively correlated with Survivin expression in rectal carcinoma .Conclusion The low expression of Survivin and high expression of PTEN might promote tumor genesis and progression of rectal carcinoma , which could be used to judge the rectal cancer clinical staging and pathologic grading .

Chronic Disease ; Humans ; Sinusitis ; diagnosis ; therapy

Humans ; Microsurgery ; methods ; Vocal Cords ; Voice Disorders ; surgery

China ; epidemiology ; Female ; Hepatitis B ; prevention & control ; transmission ; Humans ; Infectious Disease Transmission, Vertical ; prevention & control ; Pregnancy ; Pregnancy Complications, Infectious

Capillaries ; Cells, Cultured ; Down-Regulation ; Endothelial Cells ; metabolism ; Humans ; Leptin ; genetics ; metabolism ; Ophiopogon ; chemistry ; Polysaccharides ; pharmacology ; RNA, Messenger ; genetics ; metabolism

Objective To research the Alzheimer disease(AD) patients' hippocampal structure and cognitive function with the susceptibility weighted imaging (SWI) and morphological measurement,and explore the changing regularity and correlation.Methods Sixty patients (divided equally into mild,moderate and major group as the condition of the severity of the AD) and 20 healthy control groups were scanned with SWI and T1MR,then the differences between AD and healthy controls were analyzed.Results The hippocampal volumes of AD patients were smaller than that of control group.The biggest variability occured in the major group(the left was Dunnett-t =-7.03,P ＜ 0.01 ;the right was Dunnett-t =-7.52,P ＜ 0.01),the moderate group was next(the left was Dunnett-t =-6.71,P ＜ 0.01 ; the right was Dunnett-t =-6.62,P ＜ 0.01) ;and the least variability occurred in the mild group.They did not achieve statistical significance (the left was Dunnett-t =-0.86,P＞ 0.05 ;the right was Dunnett-t =-0.68,P ＞ 0.05).The hippocampus vein' s length,diameter had reduced significantly in the mild group(Dunnett-t were-5.62,-7.02,P＜ 0.001),but the number of the branches was slightly increased,which was close to the statistical significance.(Dunnett-t =1.86,P ＞ 0.05).With the progress of the AD,all of the hippocampus vein's length,diameter,and branches were reduced significantly(the Dunnett-t of the moderate were-10.10,-11.40,-2.83,P＜0.05;the Dunnett-tofthe major were-11.69,-14.68,-5.74,P＜ 0.001).AD patients blood vessel diameter,length and cognitive have correlation(r =-0.034 ～-0.517,P ＜0.05,P ＜ 0.01).Conclusion The hippocampus vein and cognitive function function change in AD patients happened in the mild stages of disease.An important supplement to the MRI conventional sequences.

Adolescent ; Adult ; Child ; Child, Preschool ; Female ; Graft vs Host Disease ; prevention & control ; Hematopoietic Stem Cell Transplantation ; methods ; Humans ; Male ; Middle Aged ; Nutritional Status ; Nutritional Support ; Young Adult

Objective To investigate the relationship of cardiac function and ventricular structure with the training intensity and the periods lived in Tibet.Methods Sixty recruits to Tibet were selected and examined of their cardiac function,cardiac ventricular structure and the changes of elctrophysiology by color Doppler echocardiography and electro cardiogram.They were examined continuously in two years.After their training for three months together,they were divided into the different training intensity groups,Group A and Group B.The 30 recruits in Group A had high-intensity training,and the others in Group B had normal training.Results After three months,their cardiac function and ventricular structure had obvious difference in comparison with the level on plain( P 0.05 ).But there were obvious differences between in Tibet and on plain in the parameters of cardiac function and ventricular structure two years later( P 0.05 ).Conclusions Hypoxia can effect the cardiac function and ventricular structure directly.After three months in Tibet,cardiac function can fit the condition of hypoxia.The parameters of cardiac function are still less than those on plain.The right ventricules are bigger and the pulmonary arteries wider as the main character of the ventricular structure changes.The indexes of cardiac function showed no significant difference with the training intensity and the periods in Tibet.

Environment ; Female ; Humans ; Immunity ; immunology ; Male ; Neoplasms ; diagnosis ; immunology ; Prognosis

Fistula ; complications ; surgery ; Humans ; Male ; Maxilla ; pathology ; Middle Aged ; Osteomyelitis ; complications ; surgery