One hundred and eight cases who had Sr(90) irradiation in preventing pterygium recurrence were studied. The average follow up period in this series was more than one year and maximum of 3 years. The following results were obtained. 1. Three pterygium recurrences out of 11 cases (27.3%) were found in group of 1200 rads and one out of 9 (11%) in 1800 rads group. These recurrent cases did not have enough amount of irradition due to patient's conditions. No pterygium recurrences were observed in 88 cases of 2400, 3000, 3600, and 4200 rads groups. We think that the amount of post irradiation for prevnting recurrence is more than 2400 rads. Subacute reaction of post irradiation occurred in 3000, 3600, and 4200 rads groups; 7 cases out of 76 cases (9.2%). Our cases have not been followed long enough to rule out late complications, especially radiation cataract and telangiectasis of conjunctival vessels. No late complications, however, have been found up to three years after Sr(90) irradiatron. 3. Post irradiative medication of hydrocortisone eye drops (0.5% qid) was continued from immediately after irradiation to 3 days after last irradiation. The application of hydrocortisone eye drops seems to decrease the rate, mitigate the symptoms, and shorten the duration of treatment of transient and subacute reactions.
Beta Particles* ; Cataract ; Follow-Up Studies ; Hydrocortisone ; Ophthalmic Solutions ; Pterygium* ; Recurrence ; Telangiectasis

The purpose of this paper is to provide reference data related to the body weight, food & water consumptions, urinalysis, hematology and serum biochemistry parameters and absolute & relative organ weights obtained from control Sprague-Dawley rats, used in the 4-week and 13-week repeated-dose toxicity studies conducted in our laboratory between 2005 and 2008. The mean, standard deviation, minimum and maximum range values for hematology and serum biochemistry parameters, data of absolute & relative organ weights, and the difference between sexes and study duration of week 4 versus 13 week are presented. The studies were conducted according to "the standards of Toxicity Study for Medicinal Products" (2005) and The KFDA Notification No. 2000-63 'Good Laboratory Practice (GLP)' (2000) issued by KFDA. These data could be used as reference material of Sprague-Dawley rats by conducting the studies to evaluate the toxicological profile of pre-clinical toxicity studies.
Biochemistry ; Body Weight ; Hematology ; Organ Size ; Rats, Sprague-Dawley ; Urinalysis ; Water