1.Biomechanical Basics of Thoraco-Lumbar Fracture-Dislocation with Paraplegia Treated by Improved Luque's Rod Fixation
Chinese Journal of Trauma 1991;0(01):-
With a spreader and improved Luque's Rod segmental fixation, operative reduction for thoraco-lumbar fracture was conducted in 60 cases of theoraco-lumbar fracture-dislocation concomitant with paraplegia. The procedure is helpful to rehabilitation exercises and the reault is satisfactory. The mechanical condition on Luque's Rod and vertebra complex and antideformity mechanism of the improved fixation has been analysed to study the merits of this new proceedure. The improved Lugue's Rod fixation was compared with the original one in the facture of thorac-lumbar spine.
2.RESULTS OF EPIRUBICIN CONTAINING REGIMENS IN THE MANAGEMENT OF 70 CASES OF MALIGNANT TUMORS
Journal of Chongqing Medical University 1986;0(02):-
A prospective study on a new antibictic antineoplastic drug Epirubicin (pharm-orubicin,EPI)in the management of malignant tumors was carried out from February 1987 to February 1990.Diseases divided into three groups, ( 1 ) 47 cases, recurrences/metastases of the initial tumor, after treatment of operation, radiation or other antineoplastic drug; (2)8 cases, after palliative operation; (3)15cases, after radical operation.The response rate was 92.9% for maligcant lymphoma. The EPI containing regimens were also effective in the patients with gastre-intestinal cancer, breast can- eer and sarcoma, etc. The main side effectsof EPI containing regimens were also analysed, and the dose-limiting toxicity was still bone marrow depression. Only one patient showed I A-V block. Tie role of EPI in chemotherapy of common malignancies was discussed
3.MANUFACTURE OF CHINA-MADE FOGARTY BALLOON CATHETER
Journal of Chongqing Medical University 1986;0(02):-
Fogarty balloon catheters have been widely used in vascular surgery, But no such products have been manufactured in China yet. The Department of Surgery of this hospital in cooperation with Chongqing Changjiang Rubber Plant has successfully developed the batch of China-made Fogarty balloon catheter, Exporime-ntswere performed on 14 dogs to investigate the acute damage to arterial and venous walls. The results indicated that the damage was slight. Therefore, we consider that the China-made Fogarty balloon catheter can be safely used in the clinic
4.Adventitia applied slow-releasing triptolide inhibits intima hyperplasia in vein graft
Chinese Journal of General Surgery 2000;0(12):-
Objective To investigate the inhibitory effect of appling slow-releasing triptolide on adventitia on the intima hyperplasia of autologous vein graft.Methods In 24 male New Zealand rabbits, external jugular vein to common carotid artery models were established, and then were divided into 3 equal groups at random: blank-control group, receiving no management on adventitia of the vein graft; F-127 control group, receiving local application of 0.5 mL of 20 % F-127 on adventitia of the vein graft; experiment group, receiving local application of 0.5 mL of 20 % F-127 containing triptolide 300?g. Vein graft specimens were harvested at 2 weeks after the operation. Histomorphologic methods were used to detect the degree of intima hyperplasia of the specimens. The expression of bcl-2 and Fas of the specimens was detected by immunohistochemistry. The apoptosis vascular smooth muscle cells (VSMC) were detected by TUNEL.Results Two weeks after vein grafting, compared to blank-control group and F-127 control group, intima hyperplasia of experiment group [intima thickness (29.9?7.6)?m, I/M 0.56?0.08] was markedly inhibited (P
5.Rearch and clinical application of materials to bile duct repair and reconstruction
Chinese Journal of General Surgery 1993;0(02):-
Objective To review experimental study and clinical application of materials to bile duct repair and reconstruction.Methods Comparison of different materials was made between advantages and disadvantages.Results Synthetic grafts such as vitallium,teflon are easy to handle,but have no flexion,and have foreign body reaction.Although autogenous free tissues such as venous patch and peritonium are resistant to infection,they are likley to lead to bile duct stricture because of lacking adeuqate blood supply.Vascularized neibouring tissues for repearing bile duct defect have satisfactory results.Conclusions To avoid bile duct striccture,vary measures should be taken to repair bile duct defecs;for segmental loss of bile duct,end to end anastomosis or Roux-en-Y biliary jejunal reconstruction should be applied.
6.Effects of Radix Salviae Miltiorrhizae on the proliferation of vascular smooth muscle cells induced by plateletderived growth factor
Chinese Journal of General Surgery 2001;0(08):-
ObjectiveTo determine the effects of Radix Salviae Miltiorrhizae (RSM) on the proliferation of vascular smooth muscle cells(SMC) induced by plateletderived growth factor(PDGF).MethodsRat arterial SMC cultured in vitro were divided into the control group, RSM group (subdivided into 3 concentration groups:2.0mg/ml, 0.4mg/ml and 0.08mg/ml),PDGF group(10ng/ml) and PDGF(10ng/ml) plus RSM (the 3 concentrations the as the same as above) group. The number of SMC and 3HTdR incorporation of SMC were measured. Results PDGF induced the increases of the number of SMC and 3HTdR incorporation of SMC significantly, which were as 3fold and 2.5fold as those of the basic situation respectively. RSM,which was dosedependent, inhibited the increase of the number of SMC and 3HTdR incorporation of SMC in the basic and PDGF stimulated situations . ConclusionsRSM may inhibit SMC proliferation in the basic and PDGF stimulated situations.
7.Trifoil peptide and gastrointestinal ulcer
Chinese Journal of General Surgery 2000;0(11):-
ObjectiveTo introduce the effect of trifoil peptides on the protection and treatment of gastrointestinal ulcer(GIU). MethodsWe reviewed literatures about trifoil peptide in its structure, distribution, physiologic effect and mechanism, and its relation with GIU. Results Trifoil peptides formed a layer of mucus glue by combining with glycoprotein ,and improved the defense ability of the gastrointestinal(GI) mucosa .Trifoil peptides repaired the GI mucosa by abjusting the movement of mucosal cells. Trifoil peptides also had the effect of antiproliferation and antiapopotosis. There was an ulcer-associated cell lineage (UACL) around GIU. In GIU, trifoil peptides unusually expressed new cells coming from UACL moved to the surface of ulcer, and repaired the ulcer. UACL can express three trifoil peptides.Used before and after the experiment, trifoil peptides have the protective and therapeutic effect on the experiment gastroenteric ulcer. ConclusionsTrifoil peptides may offer a new method to prevent and treat GIU.
8.Clinical Study on the Pathogenesis of Chronic Venous Insufficiency in the Lower Extremities
Zhengrong QIAO ; De SHI ;
Chinese Journal of Bases and Clinics in General Surgery 2003;0(03):-
Objective To explore the relationship among plasma cytokines’ level, adhesion molecules expression and skin damage in patients with chronic venous insufficiency (CVI) of lower extremities.Methods In 32 patients with CVI and 8 normal individuals as control, blood TNF ?, IL 1? and IL 2R were assayed with ELISA method; serum endothelial cell intercellular adhesion molecule 1(EC ICAM 1), polymorphonuclear CD 18 (PMN CD 18 ) and polymorphonuclear CD 11b (PMN CD 11b ) were assayed with immunohistochemical method; and ultrastructure of diseased veins was examined by electroscope.Results The results showed that the level of plasma TNF ? and IL 1? increased remarkably in Class 2-3 compared with Class 1 and control ( P 0.05) . The index of EC ICAM 1 and PMN CD 11b positively expression increased remarkably in Class 2-3 compared with that in Class 1 and control. The index of PMN CD 18 expression in Class 2-3 and Class 1 was greatly higher than that in control ( P
9.Relationship Between Nuclear Factor-Kappa B and Restenosis after Angioplasty
Guangbin HUANG ; De SHI ;
Chinese Journal of Bases and Clinics in General Surgery 2003;0(04):-
Objective To discuss the role of nuclear factor kappa B in restenosis after angioplasty.Methods Related literatures of recent 5 years were reviewed.Results Nuclear factor kappa B could lead to hyperplasia of vascular intima which resulted from proliferation and decrease of apoptosis of vascular smooth muscle cells.Conclusion Nuclear factor kappa B plays an important role in restenosis after angioplasty.
10.Effect of estrogen on vascular endothelial cells and on the development of Buerger's disease
Jingyu DENG ; De SHI ;
Chinese Journal of General Surgery 2000;0(12):-
Objective To introduce the effect of estrogen on the vascular endothelial cells and on the development of Buerger's disease. Methods The relative papers were summarized with and made a literature reviewing. Results The physiological level estrogen in vivo has protective effects on the vascular endothelial cells; however, the high level of estrogen in vivo can hurt the vascular endothelial cells,which is an important factor in the development of Buerger's disease. Conclusion Investigation of the mechanism of high level of estrogen in Buerger's patients would have a favor effect on the prevention and treatment of Buerger's disease.