1.Analysis on Safety Index of Expert’s Toll on "Study on Appraisal of TCM Treating Children Virus Pneumonia"
Journal of Zhejiang Chinese Medical University 2006;0(02):-
0.5,the variance 0.5,variance coefficient
3.Effects of Di(2-ethylhexyl) phthalate on development and metabolism in children
International Journal of Pediatrics 2013;40(5):511-513
With the development of modem technology,more and more plastic products are widely used in various fields,while bringing significant convenience to the society,it also leads to more and more environmental estrogen.The influence of plasticizer is increasing,especially on the development of children.Extensive contacting with plasticizer is considered to be closely related with gonadal digenesis,obesity and other problems in children.This review focuses on the latest research results about the basic and clinical experiments of Di (2-ethylhexyl) phthalate (DEHP),which illuminate the effects of DEHP on children's growth and metabolism,and lay foundations for rational clinical intervention and scientific plasticizer's application.
5.One case of complicated chimera Klinefelter syndrome with metabolic syndrome
Li ZHAO ; Yong-De PENG ;
Chinese Journal of Endocrinology and Metabolism 2001;0(05):-
One case of Klinefelter syndrome with complicated 46,XY/47,XXY/48,XXXXY and metabolic syndrome was reported.
6.Treatment of invasive fungal diseases in children.
Chinese Journal of Pediatrics 2013;51(4):241-245
Amphotericin B
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administration & dosage
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therapeutic use
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Antifungal Agents
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administration & dosage
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therapeutic use
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Child
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Child, Preschool
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Fluconazole
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administration & dosage
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therapeutic use
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Humans
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Mycoses
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drug therapy
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epidemiology
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prevention & control
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Practice Guidelines as Topic
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standards
7.Effects of Various Dosage and Multiple Course of Dexamethasone on Expression of WNT Signal Transduction Pathway in Lung of Premature Rats
Journal of Applied Clinical Pediatrics 2006;0(14):-
Objective To explore the effects of various dosage and multiple course of Dexamethasone(DEX) on the expressions of WNTs,?-catenin and glycogen synthase kmase-3?(GSK-3?) genes in the lung of premature rats on the 19th day of embryo.Methods Twelve pregnant SD rats were divided into 3 groups randomly:small dose DEX group,large dose DEX group and control group with 4 rats in each group.The rats in control group were injected with saline 9 g/L;rats in small dose DEX group were injected with DEX 0.4 mg/(kg?d),and the rats in large dose DEX group were injected with DEX 0.8 mg/(kg?d) after DEX was diluted to 0.5 mL with saline.On the 19th day of gestation,fetuses were surgically taken out.The reverse transcription polymerase chain reaction PCR method was used to detect expressions of WNT7b,WNT5a,WNT2,GSK-3? and ?-catenin genes mRNA.Results The expressions of WNT7b(0.55?0.19,0.64?0.54)and ?-catenin(2.03?0.58,2.40?0.89)genes mRNA in small dose DEX group and large dose DEX group were significantly higher than those of control group(WNT7b:0.18?0.10,?-catenin:1.77?0.54)(Pa
8.Function of Phosphatase and Tensin Homologue Deleted on Chromosome 10 in Formation and Maintenance of Neuronal Circuits in Brain
jing, ZHAO ; de-yuan, LI ; yi, QU ; de-zhi, MU
Journal of Applied Clinical Pediatrics 2006;0(14):-
Phosphatase and tensin homologue deleted on chromosome 10(PTEN) is a tumor suppressor which can inhibit proliferation and migration and control apoptosis in a number of cell types,mainly through inhibiting the phosphoinositide 3-kinase(PI3K) signaling pathway.A number of in vitro and in vivo studies has been instrumental in uncovering a direct correlation between deregulated PTEN/PI3K signaling and changes in neuronal morphogenesis,which is likely to have profound bearings upon the pathogenesis of neurological symptoms.This review outlines recent work on the function of PTEN during the formation and maintenance of neuronal circuits in the brain.
9.Expression of Matrix Metalloproteinase-9/Tissue Inhibitor of Metalloproteinase-1 in Rats with Tubulointerstitial Fibrosis
yan, WANG ; de-an, ZHAO ; da-sheng, YANG
Journal of Applied Clinical Pediatrics 1992;0(05):-
Objective To observe the expression of matrix metalloproteinase-9(MMP-9)/tissue inhibitor of metalloproteinase-1(TIMP-1) in tubulointerstitial fibrosis(TIF) rats and explore the effects of MMP-9 and TIMP-1 in TIF.Methods Forty-eight male Sprague-Dawley(SD) rats were randomly divided into sham-operated group(n=24) and model group(n=24).Results Tubulointerstitial fibrosis model was established via unilateral ureteral obstruction(UUO). Histological changes were observed in tubulointerstitium injury under microscope and immunohistochemistry staining was performed to investigate both the expression of MMP-9 and TIMP-1 in TIF by semiquantitative score at d7, d14, d21 after experiment onset.The expressions of TIMP-1 in rats from sham-operated group were lower than those of mo-del group rats at d7, d14, d21 (Pa
10.Influence of Oral Antigens on Expression of Costimulatory Molecules CD80/CD86 on Surface of M?
Journal of Shanghai Jiaotong University(Medical Science) 2006;0(12):-
Objective To study the influence of oral antigens on the expression of costimulatory molecules CD80/CD86 on the surface of M and to investigate the genesis of pregnancy immunological tolerance induced by oral antigens through CD80/CD86. Methods Mice of spontaneous abortion(CBA/J?DBA/2) were divided into two groups: immune group and non-immune group.Trophoblast membrane antigen-2(TMA2)or ovum albumin(OVA) was administered orally to the mice in the immune group.Mice of normal pregnancy(CBA/J?BALB/c) were served as controls.The number of CD80/CD86 M of spleen and mesenteric lymph node(MLN) were determined by double-label FCM method. Results In the MLN,CD80 M of non-immune group was increased significantly as compared with that of the control group(P