Objective To study the significance of serum uric acid in predicting coronary heart disease(CHD) risk.Methods Uric acid and its relationship with coronary heart disease(CHD) was analyzed in 215 cases who underwent coronary angiogaphy(CHD was present in 164 patients and absent in 51 as normal control group).Results Uric acid was significantly higher in patients with CHD than that in the normal control group [(316.67?97.35)?mol/L vs.(286.16?98.33)?mol/L,P

Objective To probe the safety of performing transradial artery percutaneous coronary intervention (PCI) for Allen test negative patients.Methods One hundred and six patients performed transradial artery PCI were enrolled in the study.The patients were divided into negative group (57 cases) and positive group (49 cases) according to Allen test results.Patients were performed ulnar artery angiography,deep palmar arch angiography and superficial palmar arch angiography.Ulnar artery diameter,deep palmar arch conditions,superficial palmar arch conditions,the frames counting through angiography on the side of ulnar vessel system,and hand ischemia after PCI (follow up for 3 months) was observed.Results There was no significant difference between negative group and positive group in parameters of ulnar artery diameter [(2.02 ±0.18) mm vs.(2.07 ±0.17) mm] and deep palmar arch and superficial palmar arch [85.96％ (49/57) vs.87.76％ (43/49),75.44％ (43/57) vs.81.63％ (40/49)] (P ＞0.05).The frames counting had no significant difference between negative group and positive group [(218.6 ± 63.6) frames vs.(180.8 ± 44.1) frames],but the ratio of the frames counting ≥380 frames had significant difference between negative group and positive group [14.04％(8/57) vs.2.04％(1/49)] (P ＜ 0.05).None of patients had been found to suffer from hand ischemia after PCI.Conclusion Transradial artery PCI is suitable for Allen test negative patients.

Objective To investigate the relationship of plasma brain natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels with the severity of heart dysfunction in elderly patients with heart failure. Methods BNP levels were measured by immunofluorescence in 106 hospitalized patients with heart failure, while NT-proBNP levels were measured by electrochemiluminescence immunoassay in 48 patients. The severity of heart dysfunction was determined by NYHA classification. The left ventricular ejection fraction (LVEF) measured by Color Doppler Ultrasound was used to show the left ventricular systolic function. Results In patients with BNP≤400 ng/L versus BNP>400 ng/L, the rates of LVEF≤45% were 16.4% versus 46.8% (χ~2= 13. 93, P=0. 001), the rates of E/A<1 were 62.3% versus 40. 4% (χ~2 =22. 19,P = 0.024) and the rates of Cr>107 μmol/L were 13.1% versus 38.3% (χ~2 = 11. 31, P = 0. 002) . In patients with NT-proBNP≤400 ng/L versus NT-proBNP>400 ng/L, the rates of LVEF≤45% were 25. 0% versus 58. 3% (χ~2 = 10. 00,P = 0. 019) and the rates of Cr>107 μmol/L were 20. 8% versus 50.0% (χ~2=8. 50,P = 0. 035). Conclusions BNP or NT-proBNP levels increase significantly along the deterioration of the heart failure severity, and it may be important to use BNP or NT-proBNP to predict left ventricular function.

Objective To evaluate the effect of holidays on door-to-reperfusion time in patients with ST-segment elevation myocardial infarction(STEMI).Methods Using the data from the Registry of ST-segment elevation Myocardial Infarction in Beijing,we studied the data of 297 patients with STEMI who received acute reperfusion from November 2005 to July 2006.The association between holidays and door-to-reperfusion time in these patients was studied.Results Ninty four patients in this study were admitted in holidays(26 of them received fibrinolytic therapy and 68 received PCI)and the other 203 patients were admitted during routine weekdays(61 of them received fibrinolytic therapy and 142 received PCI).After adjusting for patient characteristics,admission during holidays was associated with a longer median door-to-balloon time[162.2 min(95% CI:160.8,165.3)vs 141.8 min(95% CI:137.8,144.1);P

Objective To observe the relationship between C-reactive protein (CRP) and the stability of coronary artery lesions and major adverse cardiac events.Methods By using coronary arteriography,coronary heart disease was diagnosed in 30 stable angina patients and 45 unstable ones.serum CRP and troponin T (cTnT) levels were measured on 0hs,6hs,24hs,48hs and 7days after hospital admission.The patients were divided into two groups according to the absence or presence of major adverse cardiac events.Results There was no relationship between CRP level and the severity of coronary artery lesions,whereas the CRP level of unstable angina(3.9?0.4 mg/L)was much higher than that of stable angina(2.2?0.3 mg/L),P

China ; Humans ; Orphan Drug Production

Objective To explore the current condition of psychological problems of patients in cardiology clinic. Methods A total of 347 patients in the cardiology clinic of Prof. HU Da-yi were screened by self-rating depression scale(SDS),Self-rating anxiety scale(SAS),Hamilton rating scale for depression(HRSD)and Hamilton anxiety scale(HAMA). Results The rates of patients with somatic disease only or with psychological disorder only were 52.4%and 12.7%, the rate of somatic disease accompanied with psychological disorder was 27.7%. For the patients with psychological problems, there were 31 cases with depression(8.9%),62 cases with anxiety(17.9%),and 28 cases(8.1%) suffering from mixed depression and anxiety the diagnosis of cardiovascular disease,functional disease or digestive disease was always used by doctors for the patients with psychological problems only,as they always did not accept the diagnosis of psychological disorder. Conclusions It is very common that patients in cardiology clinic department suffered from psychological problems. The patients with psychological disorder only were easily misdiagnosed as somatic disease especially cardiovascular disease.

Objective:To compare the difference of microalbuminuria (MAU) and von Willebrand factor (vWF) between essential hypertensives and hypertensive patients with metabolic syndrome (MS), and to explore the association of these factors with MS. Methods: According to the new definition of MS by International Diabetes Federation (IDF) for 2005, 133 consecutive essential hypertensives were divi-ded into two groups: hypertensive patients with metabolic syndrome (EH-MS group, n=97), and essential hypertensives (EH group, n=36). Biochemistry assay, plasma vWF, 24 hours urine albumin excretion (UAE) and morning urine albumin/creatinine ratio (ACR) were measured. The association of MAU and vWF with MS was analysed. Results: Waist circumference, body mass index, triglyceride (TG), low density lipoprotein cholesterol (LDL-C), plasma vWF and UAE were increased(P0.05, respectively). Logistic regression showed HDL-C, TG, LDL-C,vWF and UAE were associated with the deve-lopment of MS in hypertensive patients (standardized coefficients: -0.825, 0.63, 0.339, 0.331, 0.371,P

Purpose:To evaluate the significance of surgery for pulmonary metastases and investigate the adverse factors of prognosis.Methods:Forty six patients with pulmonary metastases were studied. Operation was performed through conventional thoracotomy ( in 30 patients) and video assisted thoracoscopic surgical techniques (in 16 patients). Patients were followed up. Survival rate was calculated with Kaplan Meier method. Logistic regressive analysis was done to identify adverse prognostic factors.Results:Three year and five year survival rates were 33.8% and 15.8% respectively. Logistic multivariate regressive analysis revealed that multiple lobes metastases and metastases with lymph nodal metastases were adverse factors for prognosis.Conclusions:Surgery might cure some selected patients with pulmonary metastases. Multiple lobes metastases and metastases with mediastinal lymph nodal metastases are indicators of poor prognosis.

Objective To determine the effects of 17 β-estradiol on cellular electrophysiology and L-type Ca2+ currents (L-ICa) induced by endothelin-1 (ET-1) in ventricular papillary muscles and myocytes of guinea pig.Methods Standard microelectrodes and whole cell patch clamp techniques were used to record the action potentials and L-ICa.Results Superfusion of ET-1 for 30 minutes resulted in a marked prolongation of the action potential duration (APD) without any significant changes of APA and Vmax in ventricular papillary muscles of guinea pigs. In additional 17 β-estradiol (30 μmol/L), APD was abbreviated. In the patch clamp study, ET-1 increased the mean peak L-ICa from 534.46±46.23 to 1003.15±39.12 (pA) with peak voltage-current curve shifting to left, and steady-state activation curve was shifted in depolarization direction in contrast to the steady-state inactivation curve. However, in additional 17 β-estradiol, the L-ICa decreased by 33.32% (P<0.01) with peak voltage-current curve shifting to right and, the deviation of the steady-state activation and inactivation curves caused by ET-1 was depressed.Conclusion 17 β-estradiol attenuates ET-1-induced prolongation of APD in guinea pig papillary muscles by an inhibitory effect on L-ICa in guinea pig ventricular myocytes, which may account for its antiarrythmic effect.