To investigate the relationship between the expression of c-myc gene and genesis,devel opment and prognosis of renal cancer. Methods :The synthesis of P62 protein in 42 renal cancer and mRNA tran scription of c-myc gene in 30 renal cancer were tested by using SABC immunohistochemistry and in situ hybridza tion. Results:P62 positive were noted in 66.7％ renal cancer and overexpression of c-myc mRNA noted in 55.3％ renal cancer. In addition, there was negative relation between gene expression and tumor cell＇s differentation or prognosis of patient. Conclusion:C-myc gene may participate in prognosis of renal cancer and can be used as an index for judging malignant degree of renal cancer cells and evaluate prognosis of patients.