1.Clinical Observation of Domestic Imatinib Mesylate Tablet in the Treatment of Chronic Myeloid Leukemia
Wenjuan ZHU ; Dawei YIN ; Ju LI ; Juan JIANG
China Pharmacy 2016;27(5):671-673
OBJECTIVE:To observe therapeutic efficacy and safety of domestic Imatinib mesylate tablet in the treatment of chronic myeloid leukemia(CML). METHODS:16 CML patients were selected,including 7 newly diagnosed CML patients and 9 patients diagnosed as CML more than 12 months. Imatinib mesylate tablet 400 mg,qd were used in all patients. Blood routine, bone marrow cytology,ph chromosome Evaluate efficacy,and observed peripheral blood fusion gene,Bcr-Abl/Abl gene mutation and ADR were all detected. RESULTS:After treatment,16 patients achieved complete hematologic remission (CHR);12 cases were pavtial cytogenetic response(MCyR),of which 2 cases achieved complete cytogenetic response(CCyR),2 cases were cyto-genelic remission. 15 patients'Bcr-Abl/Abl transcript levels were less than 10%,and only one case was more than 10%. No ADR difficult to tolerate was found in 16 patients. CONCLUSIONS:Domestic Imatinib mesylate tablet shows definite early therapeutic efficacy and high safety.
2.Effects of Xiaotan Sanjie Decoction on expressions of interleukin-8 and its receptors in gastric tumor xenografts and gastric tissue adjacent to the tumor in mice.
Dawei JU ; Pinkang WEI ; Huiming LIN ; Dazhi SUN ; Shan YU ; Lijuan XIU
Journal of Integrative Medicine 2010;8(1):74-9
To explore the mechanisms of Xiaotan Sanjie Decoction (XTSJD), a compound traditional Chinese herbal medicine, in inhibiting the tumor growth and preventing recurrence by testing the protein expressions of interleukin-8 (IL-8) and its receptors chemokine receptor 1 (CXCR1) and chemokine receptor 2 (CXCR2) in gastric tumor xenografts and gastric tissue adjacent to the tumor in mice.
3.Study on changing rules for total flavonoids and total terpene lactones in Ginkgo biloba leaves at different ages of tree and collecting seasons
Dawei QIAN ; Jianming JU ; Lingying ZHU ; Jinao DUAN ; Yuhuan WANG ; Shaojun ZHANG ; Qiaosheng GUO ;
Chinese Traditional and Herbal Drugs 1994;0(11):-
Object To define suitable gathering season of Ginkgo biloba L. leaves. Methods The content of total flavonoids and total terpene lactones in G. biloba leaves were determined by HPLC DAD and HPLC ELSD. Results The content of total flavonoids and total terpene lactones in G. biloba were distinct in different ages of tree and collecting seasons. Conclusion The content of total flavonoids and total terpene lactones in G. biloba are the highest in 2 3 ages of tree. The total flavonoid is the highest in May and total terpene lactone is the highest in September.
4.Studies on dynamic change of total ginkgolic acids in Ginkgo biloba leaves of different aged trees and different collecting seasons.
Jianming JU ; Yiping HUANG ; Shihui QIAN ; Dawei QIAN ; Jin'ao DUAN ; Fuliang CAO
China Journal of Chinese Materia Medica 2009;34(7):817-819
OBJECTIVETo study dynamic change of total ginkgolic acids in Ginkgo biloba leaves of the different aged trees and different collecting seasons.
METHODThe content of total ginkgolic acids in G. biloba leaves was determined by HPLC. A Alltima C18 (4.6 mm x 250 mm, 5 microm) and the mobile phase of methanol and 1% acetic acid (90:10) were used, the flow rate was 1.0 mL x min(-1), and the wavelength was 310 nm. The content were calculated with external standard method.
RESULTThe content of total ginkgolic acids in G. biloba leaves was in the range of 0.48% to 2.51% in different collecting seasons. The content reached maximum at the end of May and the beginning of June, and then declined gradually. In different aged trees, the content in the older ages was lower than that in the younger ages.
CONCLUSIONThe results provide scientific basis for the collecting season of G. biloba leaves.
Chromatography, High Pressure Liquid ; Ginkgo biloba ; growth & development ; metabolism ; Linear Models ; Plant Leaves ; growth & development ; metabolism ; Reproducibility of Results ; Salicylates ; metabolism ; Seasons ; Sensitivity and Specificity ; Trees ; growth & development ; metabolism