Background: Meningococcal meningitis is a disease that can cause severe and possibly fatal side effects. To prevent the spread of meningococcal meningitis, which is a highly transmissible disease, 16 states in the USA mandate entering college students to receive meningococcal vaccination. Nevertheless, South Korea does not. This study aims to point out the importance of meningococcal vaccination by comparing the level of general knowledge and recognition of the requirement for vaccination among university students in the USA/Canada and Korea. Methods: The study was conducted using a self-filled questionnaire survey targeting international and Korean students at one of Korea's universities. The survey focused on topics such as knowledge of infectious diseases that can occur at the dormitory residence, infectious agents and routes of meningococcal meningitis infection and infection route, and students' intention to receive meningococcal vaccination. Results: International university students had a higher awareness of the importance of infectious disease prevention than Korean students (P<0.05) and also had higher meningococcal-related knowledge (P<0.05).International universities strongly recommend meningococcal vaccination compared to Korean universities (P<0.05), and the actual vaccination rate was higher than that of domestic university students (P<0.05). Conclusions This study found that the awareness of meningococcal vaccination among Korean university students was lower than that of international university students, and the vaccination rate was also lower. Because students often do not get vaccinated due to low awareness of the meningococcal disease, health education programs can increase their knowledge about infectious diseases and awareness of vaccines. Thus, increasing the vaccination rate.

Background: Vitamin D deficiency is a common challenge its consequences are studied to be related to diversity of other health concerns. The efficacy and safety in longevity of vitamin D3 B.O.N. 200,000 IU Intramuscular Injection were examined through investigator-initiated clinical trial. Methods: One-hundred and eight subjects between ages of 19 and 65 who showed vitamin D deficiency (serum 25(OH)D<20 ng/mL) were initially injected once and were checked every 3 months for the next 12 months for serum 25(OH)D and 1,25(OH)2D levels for the drug’s efficacy, and for other safety observations. The percentage of participants maintaining within the normal serum 25(OH)D range were analyzed. Participants who reduced in the serum level below 30 ng/mL during the regular visits were given additional injections. Results: All the subjects showed similar patterns of statistically significant improvements at all times. The percentage of participants remaining in the normal range was higher in the better compliance group. No serious adverse events or severe adverse reactions occurred. Conclusions Treatment of the vitamin D-deficient subjects with the injection of 200,000 IU vitamin D3 B.O.N. Intramuscular Injection induced a statistically significant increase in blood vitamin D concentration for 12 months demonstrating the clinical efficacy of the intervention. The higher percentage of the better compliance group being within normal ranges strengthens the evidence of the efficacy. No new adverse events or severe adverse events were associated with the injection, demonstrating its safety. Further studies to facilitate development of appropriate guidelines for interventions using vitamin D3 intramuscular injections will be desirable.