IntroductionDigestive system diseases are accounted in 4th place of the causes of mortality that are might caused by Mongolian climates and the features of food nutrition. It is a very important to obtain the natural herbal drug which has less side effect, use in medical practice for an appropriated disorder. Therefore we are put an aim of obtain a new drug from Sanguissorba officinalis L. for the treatment of diarrhea. This herbal plant grows in botanical and geographical provinces such as Khangai, Khentii, Khuvsgul, Mongol Daguur and widely distributed in Mongolia. Sanguissorba officinalis L. containes tannin substance up to 20%. Rhizome, herbs, flowers of Sanguissorba officinalis L. are widely used for the Mongolian, Tibetan, Russian, German, Korean, Poland, Hungarian traditional medicine to treat diarrhea, gastrointestinal disorders and haemostatic. This study and research work was done by Pharmaceutical Technology and Management Department of School of Pharmacy, HSUM.GoalThe aim of the study is to solve the problem of technology to obtain a tablet formulation from Sanguissorba officinalis L.Materials and MethodsWe collected and dried the flowers of Sanguissorba officinalis L. in Kherlen soum, Dornod province on August of 2010, 2011 and 2012. Choice of the optimal extragent, suitable extraction method was defined by I.A.Muraviev, U.G. Pshukov methods. The fraction of granules were determined using the method by Kozein, the bulk density of granules was determined method by Lusy Wan Cheng, to obtain tablets used by wet granulation method, to establish quality criteria of liquid extract and tablets by Mongolian National First Pharmacopeia, and the statistic analyses were done by SPSS-17 programme, using t-criteria of Student Fischer.ResultWe had extracted liquid extract from flowers of Sanguissorba officinalis L. and it has been extracted by repercolation method German pharmacopeia modification. The technological parameters of liquid extract are the main important index to calculate the extragent correctly, to establish the material balance exactly, to extract the process efficiently, to develop technological regimentation and to base account of economical benefit. We determined the technological parameters as the optimal extragent is 40% ethanol; the effective extracting method is repercolation method German Pharmacopeia modification. For the development of tablets by wet granulation method from liquid extract using various binders and choose the optimal bender was mix starch and methylcellulose past. Tablets from Sanguissorba officinalis L. was standardized by such criteria, as the amount of biologically active compound, appearance, hardness, friability, average weight, weight variation, disintegration, dissolution, amount of heavy metals and microbiological contamination by Mongolian National First Pharmacopeia.ConclusionThe result of the study was done the technological parameters of liquid extract of Sanguissorba officinalis L. such as the optimal extragent, the effective extracting method. As the result of determining these parameters, it has much practical significance for establishing the technological condition to extract the biological active compounds completely from flowers of Sanguissorba officinalis L. In the result of the study to obtain tablets from fluid extract of Sanguissorba officinalis L. has been developed and the quality criteria has been defined.