To determine effects of shift work on nurses’ health by arterial hypertension and diabetics type 2. The design of this study is cross sectional design. Subjects were 634 nurses who were chosen from 5500 nurses undertaking rotating shift work by random sampling method in accordance with criteria of research recruiting. The 64.5% of research participants were from Ulaanbaatar city and 35.5% from rural areas. Average aging is between 40.2±19.8 (p<0.0001). Three hundred three of the participants (50.8%) were night shift nurses and 293 (49.2%) day shift nurses. Obesity distribution was through trunk area at 93%. The participants’ 33.6% has high blood pressure; and 12.3% are at medium risk of diabetics and 4.2 % at high risk for near 10 years. According to test of fasting blood glucose in capillaries, 28.3 % of the nurses who are involved in the research has changes on their fasting glucose level and 14.5% has diabetics. As seeing from lab test and body index, shift nurses are at high risk of arterial hypertension and diabetics and these diseases are more common among the nurses.