Background: Hyperthyroidism is a disorder of thyroid function in which body tissues are exposed to excessive amount of circulating thyroid hormone. It causes the uncontrolable homeostatic. Objectives:This study aims to learn about the results of the treatment by antithyroid and some factors influencing these results in children at National Hospital for Pediatric. Subjects and method:A descriptive, cross sectional in combination with retrospective and prospective study was conducted on 51 patients with hyperthyroidism were treated by antithyroid in the National Hospital for Pediatric from May 1995 to May 2005 and with therapy duration from 12 months upward. Result: Remission rate was 58.8% (30/51) with an average follow - up period after therapy withdrawal of 2.5 \xb1 1.6 years (13 months in minimum) and the relapse rate was 41.2% (21/51) at the age over 10 years old. The antithyroid drug discontinuation, therapy duration <3 years, stress, infection were factors influencing treatment outcome. Relapse was of 90% when therapy duration was under 3 years. Goiter size at diagnosis moment was a significant determinant factor of relapse. Conclusion: Most patients reached remission. The factors affected treatment results were age, antithyroid drug discontinuation, therapy duration, stress, infection, late treatment, goiter size.
Hyperthyroidism/ pathology ; therapy ; Child

Background: Idiopathic nephrotic syndrome is not uncommon in children. The disease affects children's physical development. Idiopathic nephrotic syndrome cause many complication in which effecting to physical development has been influenced much to their life, study and living activities of children. Objectives:This study aims to learn about the physical development and to find some factors impacting on physical development ofchildren with idiopathic nephrotic syndrome. Subjects and method: A prospective and descriptive study was conducted on 100 patients diagnosed with idiopathic nephrotic syndrome disease who have been followed up for from 1 year to 6 years in that duration since September 2006 to March 2007. Results:Height standard deviation score (SDS) was less than -2 SO in 15.0% patients. Six per cent of patients had weight SDS ofless than 250. Delayed puberty was seen in 21.6% patients. Some factors impacting on physical developmentwere duration of the disease, relapses, nephrtitis-nephrotic syndrome, prolonged corticoid treatment. Conclusion:Idiopathic nephrotic syndrome retarded physical development and puberty in children. It should be considered careful before indicate to use corticoid because using corticoid for a long period will effect to the height development of children.
Nephrotic Syndrome/ pathology ; therapy ; Idiopathic minimal change nephrotic syndrome ; Child