Objective To evaluate the clinical application value of motor evoked potential (MEP) combined with somatosensory evoked potential (SEP) and electroencephalogram (EEG) in carotid endarterectomy (CEA) in prevention of cerebral ischemia.Methods The clinical data of 62 patients accepted CEA in our hospital from June 2014 to July 2016 were analyzed retrospectively.During the operation,MEP,SEP and EEG were examined,and the bypass rube would be considered when SEP/MEP amplitude was decreased by 50％,latency was delayed by 10％,or frequency of EEG was changed by 50％.The predictive effects of each method and combined application of 3 methods were compared.Results In 62 patients,MEP changes occurred in 11 patients,SEP changed in 15 patients and EEG changed in 8 patients.Six patients applied bypass tube during operation and a transient neurological dysfunction occurred in 5 patients.The specificity of EEG mode showed no statistical differences as compared with that of SEP+MEP,EEG+MEP,and SEP+EEG modes (P＞0.05),while that of SEP mode or MEP mode was significantly lower as compared with that of SEP+MEP,EEG+MEP,and SEP+EEG modes (P＜0.05).The specificity of SEP+MEP+EEG mode showed no statistical differences as compared with that of SEP+MEP,EEG+MEP,and SEP+EEG modes (P＞0.05).Conclusion Multi-mode neural electrophysiological monitoring is safer and more effective than single mode in CEA;MEP+SEP monitoring mode is the preferred monitoring program in CEA.