Objective To compare the changes of hs-CRP,IL-6 level,insulin secretion index (HOMA-β),insulin resistance index (HOMA-IR) in the different TCM Hou of type 2 diabetic patients.Methods 63 newly diagnosed type 2 diabetic patients were selected.According to the TCM syndrome,they were divided into combination of phlegm and heat,deficiency of both qi and yin,yin and yang deficiency three groups.20 healthy people were selected as control group.The serum hs-CRP,IL-6 and fasting blood glucose,insulin were measured.Results The levels of hs-CRP,IL-6 and insulin resistance index were lower than the other three groups,there were significant differences (t =6.948,P ＜ 0.05).There was no significant difference in insulin secretion index between the control group and the combination of phlegm and heat gruop (t =4.832,P ＞ 0.05).There were significant differences in IL-6 level and HOMA-β among different syndromes groups(t =4.985,5.043,P ＜0.05).HOMA-β from high to low was the combination of phlegm and heat group ＞ deficiency of both qi and yin group ＞ yin and yang deficiency group.Conclusion The change of IL-6 correlates with TCM syndromes,and the change of TCM syndrome with the change of islet function.IL-6 and insulin secretion index can be used as reference of TCM type.