Objective To observe the clinical efficacy of 595 nm pulsed dye laser and 595 nm pulsed dye laser combined with glycolic acid on patients with acne vulgaris.Methods From October 2017 to October 2018,60 patients with acne vulgaris (28 men,32 women,average age of 24.25 years) were divided randomly into two groups:one group was treated by 595 nm pulsed dye laser only,and other group used 595 nm pulsed dye laser combined with glycolic acid.Results The total effective rates of two groups were 50.00％ (15/30 cases) and 77.00％ (23/30 cases),respectively,and there was a significant statistic difference between the two groups (x2 =4.59,P＜0.05).Conclusions Patients with acne vulgaris have more significant benefits from 595 nm pulsed dye laser combind with glycolic acid than the laser alone.