1.Research progress on regulatory function of HOXD?AS1 in tumors
Jinglin LI ; Kaiming LENG ; Yi XU ; Daolin JI ; Zhenglong LI ; Xingming JIANG ; Yunfu CUI
Clinical Medicine of China 2018;34(1):79-82
HOXD-AS1 is a recently discovered pivotal cancer-related long non-coding RNA(lncRNA) .Abnormal expression of HOXD-AS1 exhibits a regulatory role in the occurrence and development of tumors,and is expected to become a new tumor marker.Clarifying the mechanism of HOXD-AS1 will provide a feasible theoretical basis and potential intervention targets for the diagnosis and treatment of tumors.This article reviews the current research status of HOXD-AS1 in tumors.
2.Research progress in regulatory mechanism of CCAT2 and the relationship with digestive system neoplasm
Jinglin LI ; Zhenglong LI ; Lining HUANG ; Kaiming LENG ; Daolin JI ; Yi XU ; Xingming JIANG ; Yunfu CUI
Journal of Chinese Physician 2018;20(5):790-793
Colon cancer associated transcript 2 (CCAT2) is found recently an important member of cancer-related long non-coding RNA (lncRNA).Dysregulation of CCAT2 plays a pivotal role in tumor pathophysiological processes,especially in tumourigenesis and progression of digestive system neoplasms,thus,CCAT2 likely represents a novel cancer biomarker or therapeutic target.Elucidation of the molecular mechanisms of CCAT2 will provide a feasible theoretical basis and potential interventional target for the diagnosis and treatment of malignancies.The present review summarizes current evidences of CCAT2 in digestive system neoplasms.
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