1.Research progress in regulatory mechanism of CCAT2 and the relationship with digestive system neoplasm
Jinglin LI ; Zhenglong LI ; Lining HUANG ; Kaiming LENG ; Daolin JI ; Yi XU ; Xingming JIANG ; Yunfu CUI
Journal of Chinese Physician 2018;20(5):790-793
Colon cancer associated transcript 2 (CCAT2) is found recently an important member of cancer-related long non-coding RNA (lncRNA).Dysregulation of CCAT2 plays a pivotal role in tumor pathophysiological processes,especially in tumourigenesis and progression of digestive system neoplasms,thus,CCAT2 likely represents a novel cancer biomarker or therapeutic target.Elucidation of the molecular mechanisms of CCAT2 will provide a feasible theoretical basis and potential interventional target for the diagnosis and treatment of malignancies.The present review summarizes current evidences of CCAT2 in digestive system neoplasms.
2.Research progress on regulatory function of HOXD?AS1 in tumors
Jinglin LI ; Kaiming LENG ; Yi XU ; Daolin JI ; Zhenglong LI ; Xingming JIANG ; Yunfu CUI
Clinical Medicine of China 2018;34(1):79-82
HOXD-AS1 is a recently discovered pivotal cancer-related long non-coding RNA(lncRNA) .Abnormal expression of HOXD-AS1 exhibits a regulatory role in the occurrence and development of tumors,and is expected to become a new tumor marker.Clarifying the mechanism of HOXD-AS1 will provide a feasible theoretical basis and potential intervention targets for the diagnosis and treatment of tumors.This article reviews the current research status of HOXD-AS1 in tumors.
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