OBJECTIVE:To optimize the water extraction technology for the medicinal materials in Compound gastritis cap-sule. METHODS:Orthogonal test was adopted. Using the comprehensive score of contents of paeoniflorin,salvianolic acid B and weight of dry extract as evaluation index,effects of adding water amount,decoction time and times on water extraction technology were investigated,and verification test was conducted. RESULTS:Optimized water extraction technology was as follows as decoct-ing for 3 times,120 min each time and adding 10-fold water each time. In verification test,average comprehensive score was 909.19(RSD=1.84%,n=3). CONCLUSIONS:Optimized water extraction technology is stable and feasible,and can be used for the water extraction for each medicinal material in Compound gastritis capsule.