82 benign prostatic hyperplasia (BPH) patients (between 50 and 90 years old) have undergone endoscopic surgeries with Stolz machine. Results: after 18 months, there was no death, problems of electrical knife during operation: 1.25%, post-operation complications: bleeding: 0, infection: 2 cases, and gastric hemorrhage 1 case. Late complications: dysuria 9 cases, no one developing urethral stenosis. Endoscopic surgery is superior to traditional procedures, and it needs broader application.
Therapeutics ; Endoscopy ; Prostatic Hyperplasia

In the present study, bioactivity-guided extraction and isolation of the n-hexane fraction of the fruits of Vietnamese Schisandra sphenanthera led to the isolation of five dibenzocyclooctadiene lignans as gomisin N (1), schisandrin C (2), gomisin H (3), gomisin D (4), and gomisin C (5). All the isolates were tested for their inhibition of NO production in LPS-induced RAW 264.7 cells. Among them, compounds 4 and 5 showed weak inhibition of NO production with IC 50 values of 25.0 ± 1.6 and 24.8 ± 2.0 µM, respectively. Compound 1 exhibited NO production inhibition with an IC 50 value of 15.8 ± 2.1 µM, meanwhile, schisandrin C (2) showed the most potent inhibition with an IC 50 value of 8.5 ± 0.5 µM. In addition, compound 2 had a concentrationdependent inhibitory effect on the protein expression of the inflammatory enzymes iNOS and COX-2. Their physicochemical properties and ADMET data were predicted by in silico, indicating favorable drug-like properties as well as low acute oral toxicity. The results suggest that the fruit of S. sphenanthera and its phytochemical constituents might be used as anti-inflammatory agents.