1.Effect of paclitaxel on carcino-embryonic antigen carcino-embryonic antigen, carbohydrate antigen 19-9 and carbohydrate antigen 72-4 levels in patients with advanced gastric cancer
Chinese Journal of Biochemical Pharmaceutics 2017;37(6):152-154
Objective To analysis the effect of paclitaxel on CEA, CA19-9 and CA72-4 levels in patients with advanced gastric cancer.Methods46 patients who were diagnosed with advanced gastric cancer in Pinghu hospital of traditional Chinese medicine were collected.All patients were randomly divided into experimental group and control group,23 cases in each group.The control group was treated with cis-platinum complexes and capecitabine, and the experimental group was treated with paclitaxel and capecitabine, after the treatment, the serum levels of CEA, CA19-9, CA72-4, vascular endothelial growth factor, endostatin and clinical curative effect were detected in all patients.ResultsAfter treatment, compared with control group,①the serum level of CEA was lower in the experimental group (P<0.05);②the serum level of CA19-9 and CA72-4 were lower in the experimental group (P<0.05);③the serum level of VEGF was lower in the experimental group (P<0.05);④the serum level of Endostatin was higher in the experimental group (P<0.05);⑤The clinical efficiency of the experimental group was higher(P<0.05).ConclusionsThe paclitaxel can significantly reduce the serumCEA, CA19-9, CA72-4 and VEGF levels, elevated serum Endostatin level in patients with advanced gastric cancer, improve the treatment effect, and have a guiding significance for clinica.
2.Effect of postoperative thyrotropin suppression on bone mineral density in postmenopausal women with differentiated thyroid carcinoma
Yanlei HUO ; Danyang WANG ; Shuqi WU ; Hui WANG ; Chao MA
Chinese Journal of Nuclear Medicine and Molecular Imaging 2017;37(4):212-215
Objective To investigate the effect of postoperative TSH suppression on bone mineral density (BMD) in postmenopausal women with DTC.Methods Postmenopausal women with postoperative DTC underwent thyroid residual ablation or 131I treatment for metastases at Xin Hua Hospital between September 2009 and December 2014 were enrolled and followed for 2 years.They were divided into suppressive TSH group (median TSH<0.30 mU/L;group 1) and non-suppressive group (median TSH≥0.30 mU/L;group 2).Lumber 1-4 BMD levels (T scores) were measured by a dual energy X-ray absorptiometry bone densitometer at baseline,1 year and 2 years after treatment.All patients had calcium and vitamin D supplementation after TSH suppression.The T scores were compared with Mann-Whitney u test and Kruskal-Wallis test.Results A total of 126 patients were enrolled and followed up for 2 years,including 65 with average age (57.65±6.65) years in group 1 and 61 with average age (56.19±7.17) years in group 2.The T scores in group 1 and group 2 at baseline were-1.70(-2.30,-0.55) and-1.30(-2.10,-0.30) (z=-1.660,P> 0.05).The difference of T scores was significant in group 1 at baseline,1-year follow-up and 2-year follow-up (-2.25(-2.48,-0.83),-1.95(-2.70,-0.60);H=6.244,P<0.05),but not significantly different in group 2 (H=1.102,P>0.05).The T values were different between the 2 groups both in 1-year follow-up and 2-year follow-up (z values:-2.170,-2.160,both P<0.05).Conclusions TSH suppression significantly increases the risk of postoperative osteoporosis.The BMD should be followed up annually in postmenopausal DTC patients.
3.Application of 123/131I-MIBG in the diagnosis and treatment of pediatric neuroblastoma
Yanlei HUO ; Danyang WANG ; Hui WANG ; Chao MA
Chinese Journal of Nuclear Medicine and Molecular Imaging 2017;37(3):173-176
As a type of neuroendocrine tumors, neuroblastoma (NB) is the most common extra-cranial solid tumor of childhood.123/131I-MIBG scintigraphy is a standard imaging modality in staging and evaluating therapeutic effect of pediatric NB with high accuracy.131I-MIBG treatment is effective for children with high-risk and relapsed/refractory NB.Combined with chemotherapy, stem cell transplantation, 131I-MIBG treatment shows efficacy in decreasing the relapse of pediatric NB.This review summarizes the application of MIBG scintigraphy and 131I-MIBG treatment for pediatric NB.
4.Effects of diabetes on ischemic/reperfusion injury and cell apoptosis in rats myocardium via alterations in peroxynitrite
Guochuan MA ; Yan XIA ; Hongman XUE ; Haobin SU ; Huan CHEN ; Danyang CEN ; B.caldwell RUTH ; Caldwell R.WILLIAM
Chinese Journal of Pathophysiology 1999;0(09):-
AIM:To determine the effects of different-term streptozotocin(STZ)-induced diabetes on ischemia/reperfusion(I/R)injury and cell apoptosis in rats myocardial via alterations in myocardial peroxynitrite.METHODS:The models of I/R injury were induced by occlusion and reperfusion of the left descending coronary artery(LDCA)in rats.I/R-induced infarct size was determined using triphenyltetrazolium chloride(TTC)staining.Quantified caspase-3 expression was used to represent apoptosis by Western blotting analysis.Peroxynitrite formation as indicated by nitrotyrosine level was measured by morphometric analysis.RESULTS:Two weeks after STZ treatment,infarct size(35.00%?3.00%)was smaller in 2 weeks diabetic hearts(2WKD)as compared with time-matched control group(2WKC)(51.00%?3.30%),whereas after 16 weeks of diabetes(16WKD),the infarct size(61.00%?3.00%)was bigger in the diabetic hearts as compared with the 16WKC group(50.00%?2.00%,P
5.The correlation between the timed up and go test and fall risks in elderly frail patients
Zhao MA ; Jianjun WANG ; Xia GAO ; Aixin GUO ; Jin XING ; Danyang SONG ; Zheng WANG ; Fei LI ; Xiaoya ZHANG ; Mengyan SUN
Chinese Journal of Geriatrics 2021;40(5):614-617
Objective:To evaluate the correlation between the timed up and go(TUG)test and fall risks in elderly frail patients.Methods:From July to September 2019, elderly frail patients who were treated at the cardiovascular department of our hospital were enrolled.Basic clinical data and fall-related information of patients were collected.Patients were divided into the fall group and the non-fall group.Results on the body mass index(BMI), TUG, 4-meter maximum walking speed(4 m MWS)and Barthel index were compared between the two groups.The correlation between TUG and each indicator was examined.Multivariate Logistic regression analysis was used to analyze the correlation between the TUG and falls in elderly patients.Results:A total of 96 eligible patients were enrolled, including 35 in the fall group and 61 in the non-fall group.The average TUG time was longer in the fall group than in the non-fall group(16.45±6.44 s vs.10.17±2.91 s, t=-6.556, P<0.001). The correlation analysis results showed that the TUG was correlated with falls and 4 m MWS( r=0.582 and 0.875, both P<0.001). Multivariate Logistic regression analysis showed that the TUG( OR=1.201, 95% CI: 1.111-1.470, P=0.004)and 4 m MWS( OR=1.146, 95% CI: 1.063-1.244, P=0.015)were risk factors for falls. Conclusions:The TUG is correlated with fall risks in elderly frail patients and should be recommended as a routine test in clinical practice.
6.On the Path of Integrating Red Doctor’s Spirit into the Ideological and Political Course of Medical Students
Chinese Medical Ethics 2024;35(1):99-103
Red doctor’s spirit is an important part of China’s advanced revolutionary culture and a valuable resource for medical students’ ideological and political education. Under the background of the new era, integrating the red doctor’s spirit into the ideological and political course of medical students is not only conducive to encouraging medical students to bravely shoulder the responsibility of the times and actively participate in the cause of human health, but also helps medical students to inherit the red culture and strengthen cultural confidence, which is also of great significance to improving the vitality and effectiveness of ideological and political courses.Teachers of Ideological and political courses should deeply explore the new era connotation of the red doctor’s spirit and constantly improve the guiding force of ideological and political courses; using Virtual Reality technology to realize the visual expression of red medicine spirit and enhance the appeal of ideological and political course; skillfully use four kinds of classes to strengthen the recognition of ideological and political course.
7.On the Path of Integrating Red Doctor’s Spirit into the Ideological and Political Course of Medical Students
Chinese Medical Ethics 2022;35(1):99-103
Red doctor’s spirit is an important part of China’s advanced revolutionary culture and a valuable resource for medical students’ ideological and political education. Under the background of the new era, integrating the red doctor’s spirit into the ideological and political course of medical students is not only conducive to encouraging medical students to bravely shoulder the responsibility of the times and actively participate in the cause of human health, but also helps medical students to inherit the red culture and strengthen cultural confidence, which is also of great significance to improving the vitality and effectiveness of ideological and political courses.Teachers of Ideological and political courses should deeply explore the new era connotation of the red doctor’s spirit and constantly improve the guiding force of ideological and political courses; using Virtual Reality technology to realize the visual expression of red medicine spirit and enhance the appeal of ideological and political course; skillfully use four kinds of classes to strengthen the recognition of ideological and political course.
8.Discussion on online teaching of prosthodontics during the outbreak of COVID-19
Yanping ZUO ; Danyang WANG ; Xiaoming CUI ; Xinyang MA
Chinese Journal of Medical Education Research 2022;21(7):833-837
Prosthodontics is an important undergraduate course in stomatology. It's an unprecedented challenge for teachers to give theoretical lectures completely by online teaching methods. After several months of online teaching practice, a complete closed-loop online teaching mode of "pre-class, in-class and after-class" has been formed by using online teaching tools such as Tencent meeting, Superstar learning platform and WeChat. A comprehensive feedback and assessment mechanism has also been established. On the premise of the teaching quality, online teaching has also promoted the exploration and reform of the information-based teaching of prosthodontics course.
9.Application of 123/131I-MIBG in the diagnosis and treatment of pediatric neuroblastoma
Yanlei HUO ; Danyang WANG ; Hui WANG ; Chao MA
Chinese Journal of Nuclear Medicine and Molecular Imaging 2017;37(3):173-176
As a type of neuroendocrine tumors,neuroblastoma (NB) is the most common extra-cranial solid tumor of childhood.123/131I-MIBG scintigraphy is a standard imaging modality in staging and evaluating therapeutic effect of pediatric NB with high accuracy.131I-MIBG treatment is effective for children with high-risk and relapsed/refractory NB.Combined with chemotherapy,stem cell transplantation,131I-MIBG treatment shows efficacy in decreasing the relapse of pediatric NB.This review summarizes the application of MIBG scintigraphy and 131I-MIBG treatment for pediatric NB.
10. Effects of PSMB5 on proliferation and bortezomib chemo-resistance in human myeloma cells and its related molecular mechanisms
Huimin MO ; Qingyun WU ; Danyang HAN ; Rui LIU ; Xun MA ; Ping ZHOU ; Kailin XU
Chinese Journal of Hematology 2017;38(12):1053-1057
Objective:
To investigate the effects of proteasome beta 5 subunit (PSMB5) on proliferation and bortezomib (BTZ) chemo-sensitivity of multiple myeloma (MM) and its related molecular mechanisms.
Methods:
We used two MM cell lines, RPMI 8226 and BTZ drug-resistant cell line RPMI 8226/BTZ100 (hereinafter referred to as BTZ100) , as the research object. PSMB5 was overexpressed or knocked down in two myeloma cell lines via lentivirus transfection. CCK8 assay was used to detect the impact of PSMB5 on cell viability and bortezomib sensitivity in human myeloma cells; Using flow cytometry to test the effects of PSMB5 on apoptosis rate of human myeloma cells under the treatment of bortezomib; Apoptosis-related gene expression of Bax, Bcl-2, p-Akt and cleaved caspase-3 were detected by Western blot.
Results:
①PSMB5 overexpression and knockdown were successfully constructed in RPMI 8226 and BTZ100 cells. ②PSMB5 expression was positively correlated with cell proliferation of RPMI 8226 and BTZ100 cells (