Objective To observe the effect of triptolide on destruction of bone and joint of collageninduced arthritis (CIA) mouse. Methods Female DBA/1 mice were double immunized at the base of the tail with bovine type Ⅱ collagen (C Ⅱ). CIA mice were randomly divided into model group, methotrexate-treated group and 8.18, 16.36, 32.72 ?g/kg triptolide-treated groups. Performance of arthritis were observed regularly. Combined with radiologieal, histological methods were used, and the number of osteoelasts in bone was evaluated and analyzed with TRAP stainning. Results The clinical score and arthritis incidence of CIA mice were significantly decreased, and the number of osteoelasts in bone cavity reduced by treatment of triptolide. X-ray showed that the surface of bone of each articular was eroded, the joint space was narrow, BMD values of lumbar and knee were decreased compared with normal mice. Triptolide could significantly inhibit the damage of bones and joints of CIA mice, and increase the BMD values of lumbar and knee. Conclusion Triptolide can inhibit the damage of bones and joints of CIA mice.

Objective:To systematically describe and analyze the related factors of self-compassion in cancer patients.Methods:Observational studies on factors related to self-compassion in cancer patients were retrieved through computer on PubMed, CINAHL, Embase, Web of Science, Cochrane Library, PsycINFO, China Biomedical Literature Database, China National Knowledge Infrastructure, VIP, and WanFang Data. The search period was from the establishment of the database to July 2022. Two researchers independently screened the article, extracted data, and evaluated the quality of the article based on inclusion and exclusion criteria. Meta-analysis of related factors was conducted using Stata 15.1 software.Results:A total of 20 articles were included. Meta-analysis results showed that self-compassion was positively correlated with age, education level, and psychological resilience, while negatively correlated with body image, anxiety, depression, and pressure. The related factors for self-compassion in cancer patients included individual factors (such as gender, age, educational level, anxiety, depression, attachment type, body image and psychological resilience) , disease factors (treatment methods) , and environmental factors (marital status, social support, place of birth) .Conclusions:There are many factors related to self-compassion in cancer patients. Medical and nursing staff can identify low-level self-compassion patients in the early stage based on related factors and carry out intervention to promote positive clinical outcomes for patients.