No abstract available.
Dantrolene* ; Malignant Hyperthermia*

No abstract available.
Dantrolene ; Malignant Hyperthermia

No abstract available.
Dantrolene ; Malignant Hyperthermia

Neuroleptic malignant syndrome (NMS) is a fatal complication most often caused by an adverse reaction to neuroleptic or antipsychotic drugs, and is mostly brought out in the initial stage of medication. Late onset NMS after long term intake of neuroleptics is uncommon, and the neurochemical mechanism is undiscovered. We report a patient of late onset NMS after a long term intake of haloperidol who was successfully treated with dantrolene and bromocriptine.
Antipsychotic Agents ; Bromocriptine ; Dantrolene ; Haloperidol ; Humans ; Neuroleptic Malignant Syndrome

Fever (body temperature above 38℃) is relatively common during the first few days after general anesthesia. Postoperative fever is usually caused by the inflammation induced by surgery and resolves spontaneously; however, it can be a manifestation of a serious complication such as malignant hyperthermia. We report a case of postoperative hyperthermia (body temperature > 40℃) that was refractory to conventional anti-pyretic measures and finally resolved with dantrolene administration.
Anesthesia, General* ; Dantrolene* ; Fever ; Humans ; Inflammation ; Malignant Hyperthermia* ; Postoperative Period

Humans ; Abdomen ; Dantrolene ; East Asian People ; Malignant Hyperthermia

We experienced a malignant hyperthermia in 24-year-old male with sevoflurane during the mandibular prognathism surgery. The malignant hyperthermia emerged 150 minutes after induction of general anesthesia using propofol, rocuronium, sevoflurane, N2O and O2. Sevoflurane has been reported that it can induce delayed onset of malignant hyperthermia under absence of succinylcholine. The prognosis of malignant hyperthermia is determined by early recognition, vigorous treatment and the time of dantrolene injection. In our case, when we suspected episode, all anesthetics were stopped and dantrolene injection was immediately given intravenously. The patient recovered normal temperature and consciousness without any complication.
Anesthesia, General* ; Anesthetics ; Consciousness ; Dantrolene ; Humans ; Male ; Malignant Hyperthermia* ; Prognathism ; Prognosis ; Propofol ; Succinylcholine ; Young Adult

Masseter muscle rigidity may herald a fulminant malignant hyperthermia reaction or may be an isolated abnormal anesthetic response. It is very hard to differentiate, Significant masseter muscle rigidity is a muscle spasm of at least 30 seconds duration that interferes with mouth opening despite an appropriate succinylcholine dose in a patient who has no temporo-mandibular joint dysfuntion. They thought mild to moderate foims of spasm are tolerable for anesthesia. We suffered incomplete relaxation of masseter muscle after succinylcholine that followed by fulminant malignant hyperthermic reaction. At that time, a little resistance was felt during mouth opening put intubation was done . without difficulty. After this experience, because Caffeine-Halothane contracture test is performed only in limited institutes and dantrolene is not available in our hospital, we decide to hold the anesthetic practice in case of any degree of masseter muscle rigidity.
Academies and Institutes ; Anesthesia ; Contracture ; Dantrolene ; Humans ; Intubation ; Joints ; Malignant Hyperthermia* ; Masseter Muscle* ; Mouth ; Relaxation* ; Spasm ; Succinylcholine

We experienced a case of malignant hyperthermia (MH) in 6-year-old boy during anesthesia induction for strabismus surgery. It has been generally reported that sevoflurane can induce the delayed onset of MH in the absence of succinylcholine. Our case of MH was elicited after about 2-3 min of sevoflurane administration with N2O, O2 and rocuronium. However, we successfully treated the patient by early recognition of his condition and administering symptomatic treatment and dantrolene.
Androstanols ; Anesthesia ; Child ; Dantrolene ; Humans ; Malignant Hyperthermia ; Methyl Ethers ; Strabismus ; Succinylcholine

Malignant hyperthermia is of particular interest to ophthalmologist because of higher incidence in children and its' potential for occurrence in strabismus and blepharoptosis patients. We analyzed the serologic data including serum CPK and the effectiveness of dantrolene sodium in strabismus children for screening carriers of malignant hyperthermia. The results were as follows; 1. Comprehensive studies including family history, laboratory test, underlying muscular disorder, muscle biopsy for susceptible individuals can help to make the diagnosis accurately. 2. No significant difference on serum CPK, LDH, GOT levels between the strabismus patients and control groups. 3. Dantrolene Sodium is effective agent for preventing malignant hyperthermia. 4. General anesthesia or stress associated with surgery and sex were the factors influencing serum CPK levels(i.e., values were significantly higher in postoperative periods and males).
Anesthesia, General ; Biopsy ; Blepharoptosis ; Child* ; Dantrolene ; Diagnosis ; Humans ; Incidence ; Malignant Hyperthermia* ; Mass Screening ; Postoperative Period ; Strabismus*