1.Artesunate combined with vinorelbine plus cisplatin in treatment of advanced non-small cell lung cancer: a randomized controlled trial.
Zhuyi ZHANG ; Shiqing YU ; Liyun MIAO ; Xiaoying HUANG ; Xiaoping ZHANG ; Yuping ZHU ; Xiaohong XIA ; Danqi LI
Journal of Integrative Medicine 2008;6(2):134-8
To our knowledge, there has been no clinical report of artesunate in the treatment of lung cancer. This study was designed to compare the efficacy and toxicity of artesunate combined with NP (a chemotherapy regimen of vinorelbine and cisplatin) and NP alone in the treatment of advanced non-small cell lung cancer (NSCLC).
2.Research Progress of TCM in Improving Ulcerative Colitis Based on PI3K/AKT Signaling Pathway
Yuping SHU ; Danqi YU ; Yue RONG ; Hongwu TAO ; Yuedong LIU
Chinese Journal of Information on Traditional Chinese Medicine 2024;31(2):191-196
Ulcerative colitis(UC)is a common disease of the digestive system.Phosphatidylinositol-3-kinase(PI3K)/synuclein/threonine kinase(AKT)is closely related to cell survival,apoptosis,inflammation and other biological processes,and the expression levels of PI3K and AKT significantly increase during the course of UC,with accelerated apoptosis,improved inflammation,and damaged intestinal mucosal barrier function.In recent years,a large number of basic and clinical trials have been conducted on PI3K/AKT signaling pathway in TCM,and the results indicate that PI3K/AKT signaling pathway is expected to be an important potential target for UC treatment.This article analyzed the mechanism of the regulation of PI3K/AKT signaling pathway in TCM from monomer,extract,compound and acupuncture,and suggested that the regulation of this signaling pathway is of great significance for the prevention and treatment of UC,and provide reference for drug development.
3.Allergen analysis of patients with allergic rhinitis in Quanzhou.
Zhenru QUE ; Qian RAN ; Danqi LIN ; Zhibin ZHANG ; Jiyi CAI ; Yu XU ; Qinhui HUANG
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2013;27(20):1148-1150
OBJECTIVE:
To understand the distribution of allergens in patients with allergic rhinitis (AR) in Quanzhou, for the diagnosis, prevention and treatment.
METHOD:
Twenty standardized allergen underwent skin prick testing (skin prick test, SPT) were used for 1236 patients with suspected AR patients in Quanzhou, and the different age, gender and severity in patients with allergen distribution differences of positive rate were analyzed.
RESULT:
The top 5 allergens with positive skin tests were D. pteronyssinus (66.7%), D. farinae (65.5%), Blattodea (32.8%), Sea crab (18.2%), and Sea lobster (16.8%). The positive rate of SPT in the minor groups and adult groups had significant difference (P < 0.05). Gender difference between the positive rate of SPT had no significant difference (P > 0.05). There was significant difference between the positive rate in patients with a family history and history of asthma and patients without above two history (P < 0.05).
CONCLUSION
Dust Mite, Blattodea, Sea crab. Sea lobster are the most important allergens in quanzhou. Different ages of the patients with SPT positive rates vary, a family history, history of asthma patients with positive rate is higher than patients without a family history of asthma history, high positive rate.
Adolescent
;
Adult
;
Aged
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Allergens
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analysis
;
immunology
;
Animals
;
Child
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Child, Preschool
;
China
;
epidemiology
;
Female
;
Humans
;
Male
;
Middle Aged
;
Rhinitis, Allergic
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Rhinitis, Allergic, Perennial
;
diagnosis
;
epidemiology
;
immunology
;
Skin Tests
;
Young Adult