Objective To evaluate the efficacy of 0.1% tacrolimus ointment and 0.1% mometasone furoate cream in the treatment of chronic actinic dermatitis (CAD). Methods Forty male patients with CAD were recruited and divided into two groups randomly.Twenty cases were treated with 0.1%tacrolimus ointment (Group A), and the other 20 cases were treated with 0.1% mometasone furoate cream (Group B) . The medications mentioned were applied topically to the lesions on the face twice a day and mizolastine tablet 10 mg per day given orally for 4 weeks. The therapeutic efficacy and side effects of medications were observed. The enzyme linked immunosorbent assay (ELISA) method was used to measure the serum levels of IFN-γ, IL-2 and IL12 in CAD patients before and after treatment with topical tacrolimus ointment and mometasone furoate cream. Results (1) Both groups had overall response rates of 100%, with no statistically significant difference ( > 0.05) . (2) Serum levels of IFN-γ,IL-2 and IL-12 were down-regulated after treatment in both treatment groups respectively ( < 0.01) . No statistically significant difference was found between the two treatment groups ( > 0.05) . Conclusion 0.1%tacrolimus ointment is effective in the treatment of CAD. Its therapeutic efficacy is equivalent to that of 0.1%mometasone furoate cream. It can be used as a possible steroid sparing equivalent.

Objective To explore the application value of fiberoptic bronchoscopy in the diagnosis and treatment of chronic cough in children. Methods A total of 113 children with chronic cough were enrolled in our hospital from January 2014 to December 2016. All the cases underwent fiberoptic bronchoscopy,the endoscopic manifestations and clinical symptoms were analyzed,and the pathogens in bronchoalveolar lavage fluid were detected. Results In the 113 children with chronic cough,64 cases (56. 6％) were boys and 49 cases (43. 4％) were girls,with 85 cases (75. 2％) under 5 years old. After fiberoptic bronchoscopy,30 cases (26. 5％) were diagnosed with bronchial foreign body,20 cases (17. 7％) were post-infection cough, 19 cases (16. 8％) with cough variant asthma,14 cases (12. 4％) with upper airway cough syndrome,14 cases ( 12. 4％) had airway abnormality, 9 cases ( 7. 9％) had protracted bacterial bronchitis, 4 cases (3. 6％) had bronchiolitis obliterans,and 3 cases (2. 7％) had bronchial tuberculosis. The most common pathogen was Streptococcus pneumonia in bronchoalveolar lavage fluid. The main adverse reactions in the operations was hypoxemia caused by airway obstruction. Conclusion Fiberoptic bronchoscopy is a very safe and reliable operation in the diagnosis and treatment of respiratory diseases in pediatrics, and plays an important role in the diagnosis of congenital developmental airway diseases,the detection of pathogens and the treatment of bronchial foreign bodies. For the chronic cough children who had repeated visits and poor treatment should accept fiberoptic bronchoscopy examination.

OBJECTIVES: With the increasing detection rate of lung nodules, the qualitative problem of lung nodules has become one of the key clinical issues. This study aims to evaluate the value of combining dynamic contrast-enhanced (DCE) MRI based on time-resolved imaging with interleaved stochastic trajectories-volume interpolated breath hold examination (TWIST-VIBE) with T₁ weighted free-breathing star-volumetric interpolated breath hold examination (T₁WI star-VIBE) in identifying benign and malignant lung nodules. METHODS: We retrospectively analyzed 79 adults with undetermined lung nodules before the operation. All nodules of patients included were classified into malignant nodules (n=58) and benign nodules (n=26) based on final diagnosis. The unenhanced T₁WI-VIBE, the contrast-enhanced T₁WI star-VIBE, and the DCE curve based on TWIST-VIBE were performed. The corresponding qualitative [wash-in time, wash-out time, time to peak (TTP), arrival time (AT), positive enhancement integral (PEI)] and quantitative parameters [volume transfer constant (Ktrans), interstitium-to-plasma rate constant (Kep), and fractional extracellular space volume (Ve)] were evaluated. Besides, the diagnostic efficacy (sensitivity and specificity) of enhanced CT and MRI were compared. RESULTS: There were significant differences in unenhanced T₁WI-VIBE hypo-intensity, and type of A, B, C DCE curve type between benign and malignant lung nodules (all P<0.001). Pulmonary malignant nodules had a shorter wash-out time than benign nodules (P=0.001), and the differences of the remaining parameters were not statistically significant (all P>0.05). After T₁WI star-VIBE contrast-enhanced MRI, the image quality was further improved. Compared with enhanced CT scan, the sensitivity (82.76% vs 80.50%) and the specificity (69.23% vs 57.10%) based on MRI were higher than that of CT (both P<0.001). CONCLUSIONS T₁WI star-VIBE and dynamic contrast-enhanced MRI based on TWIST-VIBE were helpful to improve the image resolution and provide more information for clinical differentiation between benign and malignant lung nodules.
Adult ; Humans ; Retrospective Studies ; Magnetic Resonance Imaging ; Plasma ; Tomography, X-Ray Computed ; Lung