Objective:To explore the effect of homemade aromatic masks on nausea, vomiting and pain in non-small cell lung cancer patients with chemotherapy.Methods:From October 2018 to August 2019, convenience sampling was used to select 82 patients with non-small cell lung cancer admitted to the 900th Joint Logistic Support Unit of the People's Liberation Army of China. All patients were randomly divided into control group and experimental group, each with 41 cases. Control group carried out the routine care, and experimental group was treated with the homemade aromatic mask on this basis. The Chinese version of Index of Nausea and Vomiting and Retching (INVR) and the Brief Pain Index (BPI) were used to compare nausea, vomiting and pain indicators of patients between two groups during chemotherapy.Results:On the third day of chemotherapy, the total score of nausea and vomiting, and the average pain score of experimental group were (11.00±5.46) and (1.63±1.14) respectively, lower than those of control group, and the differences were statistically significant ( t=-6.635, -4.781; P<0.01) . Conclusions:The homemade aromatic mask can relieve chemotherapy-induced nausea and vomiting in non-small cell lung cancer patients with chemotherapy, and reduce the pain of patients.