Objective To study the structure and function changes of heart in elderly patients with hypertension. Methods Two hundred old patients with hypertension in our hospital were enrolled in this study. Which were divided into elderly aged group (≥ 80 years old, 76 cases) and non-elderly aged group (<80 years, 124 cases). The SBP, DBP, LVDd, VPWd, IVST, LVDs, LAD, EF and FS were compared between the two groups. Results There were no significant differences of SBP and DBP between the two groups(P>0.05). The LVDd, LVDs, and LAD in elderly aged group were higher than that in non-elderly aged group (P<0.05). The LVPWd and IVST in elderly aged group were lower than that in non-elderly aged group (P<0.05). There were no significant differences of EF and FS between the two groups (P>0.05). Conclusion The cardiac structural changes are more early than function changes in elderly hy-pertensive patients.

Hepatosplenic candidiasis (HSC) is a rare type of candidiasis that can occur in patients with hematologic malignancies, hematopoietic stem cell transplantation. At present, there is still a lack of studies on HSC in patients with hematologic disorders. Based on The Chinese Guidelines for the Diagnosis and Treatment of Invasive Fungal Disease in Patients with Hematological Disorders and Cancers (the 6th revision), We retrospectively analyzed the clinical characteristics and prognosis of patients with HSC treated in Peking University Institute of Hematology from 2008 to 2022. Finally, eighteen patients were included, with 1 (5.6%) proven, 2 (11.1%) probable, and 15 (83.3%) possible HSC. Among them, 3 (16.7%) patients occurred after haploid hematopoietic stem cell transplantation and 15 (83.3%) patients occurred after chemotherapy. 6 (33.3%) patients had positive blood cultures, including 4 cases of Candida tropicalis and 2 cases of Candida albicans. At 4 weeks of antifungal therapy, 10 (58.8%) patients achieved partial response (PR), At 8 weeks, 1 (6.3%) patients achieved complete response and 10 (62.5%) patients achieved PR. At 6 months after diagnosis, 3 (16.7%) patients died of hematopoietic recurrence, and none of them died of HSC. As a rare fungal infection disease, HSC has a low positive rate of microbiological and histological examinations, a persistent treat cycle, and has difficulty in remission, reminding us of the need for vigilance in patients with hematopoietic disorders and persistent fever.