Objective To evaluate the incidence of benign gallbladder disease and the relationship between the hyperlipidemia and gallbladder stone in Hefei district by a survey in 6?946 persons. Methods All benign gallbladder diseases were discovered by Colour Dopple ulterasound. The data of lipidemia were analyzed and a comparative study of 1?051 cases suffering from gallbladder stone with the control group was done. Results The morbidity of benign gallbladder diseases was 21 55%. The prevalence of gallbladder stone, gallbladder polypoid lesion, cholecystitis, intrahepatic cholelithiasis or choledocholithiasis were 15 13%, 3 39%, 1 35%, 0 96%, 0 70% respectively in all examined. The morbidity of gallbladder stone was 70 2% in the benign gallbladder diseases. The incidence of hyperlipidemia both in gallbladder stone group and control group were 56 9% and 32 3% ( P