Objective To investigate the expression of preferentially expressed antigen of melanoma (PRAME) gene in acute leukemia and its clinical significance.Methods PRAME mRNA levels were detected in bone marrow samples from 119 cases with acute leukemia (out of which 97 cases were acute myeloid leukemia, 22 cases were acute lymphocytic leukemia) by TaqMan based real-time quantitative PCR methods and compared it with the expression of FLT3 gene. Results PRAME mRNA was revealed in 50 of 97 AML (51.5 %), 8 of 22 ALL (36.4 %), and 5 patients were found little expression of PRAME in 11 healthy subjects and 17 non-blood disease patients. However, 17 AML, and 3 ALL patients with PRAME expression had no detectable FLT3. 9 patients with the expression of both PRAME and FLT3 genes were monitored in short follow-up. The lower level of PRAME was detected in all patients when they were in complete remission (CR) after chemotherapy. Conclusion PRAME gene was expressed in acute leukemia patients and will hopefully become a symbolic gene during the course of diagnosis and treatment in acute leukemia.

This article summarized the management status of scientific research fund of our hospital. It focused on the whole process management which included the establishment,application and permission of the fund,supervision and tracking of the granted projects.All the management process was dealt with the management mode including standard management,scientific management and tracking management.Some effective experiences were obtained from the whole process management.

It is key for research institutions to ensure the standardized supervision of the progression and fund use of research projects.Peking University People's Hospital designed and applied a whole-process management mode of projects based on information system,which oversaw the conduct and funds management of projects.The application of this mode has significantly promoted the management level of scientific research projects.

Since Peking University People's Hospital Research and Development Funds were founded as "Seed Funds" in 2006, its management concept has been developing. During the development, the policy-oriented service replaced the policy-based single service. The three-dimensional service system was formed. As the result, the scientific research outputs increased annually with good development condition.

With the improvement in new drug clinical trials, our hospital has participated in more and more international multi-center clinical trials. Meanwhile, problems arise in carrying out these trials.We here analyzed these problems and put forward some measures for improvement.

The scientific research achievements and possible impact factors were analyzed statistically in the hospital during the past 10 years,especially in 2007,and the analysis result showed the development trends of the scientific research and impact factors of rewards.Also,to improve medical scientific research and its management level,the author proposed the related countermeasures and suggestions in this artiele.

Fine management of scientific research funds is an important support for implementation of scientific research projects and promotion of scientific researches in hospital.In order to ensure effective usage of scientific research funds and sustainable development of scientific research,Peking University People's Hospital has laid much stress on the management of scientific research funds,and explored the methods and measures for fine management of scientific research funds.

Object To establish and apply an evaluation method based on DEA in NSFC project performance evaluation. Methods Based on the analysis of NSFC projects in Peking University People's Hospital,this paper determined the evaluation index system of NSFC projects.The outputoriented DEA was selected and applied in the performance evaluation.Results We figures out the DEA ratio of every NSFC project with the established method in the program of DEAP Version 2.1.Conclusion The method based on DEA can reflect the performance of NSFC projects,and the evaluation results can provide project managers and the management department of NSFC with evidences and references to make polices for project management.

Based on the analysis of the status quo and problems of the management of companyfunded research projects,the feasible management measures are proposed and a standardized management mode for company-funded research projects is established.The establishment and application of the management mode are effective in regulating the supervision and management of those projects,facilitate the implementation of the projects,and optimize the use of research funds.

Objective To summarize the hospital research and development fund achievements in 5 years,continuing to promote innovative management concept.Methods By summarizing the fund's input and output of scientific research during 2006 to 2010,analysis of the effects in the cultivation of medical scientific research personnel and promotion of discipline development in hospital after the implementation of innovative management ideas.Results After the implementation of the innovation process management,output of fund is well.It has played a positive role in promoting to the scientific research personnel and discipline development.Conclusion It should be further promoted of the innovation process management idea,in order to further play the role of seed fund role in talent,discipline development.