Objective To investigate the belief about medicines in cerebral ischemic stroke (CIS) patients and its influencing factors .Methods The belief about medicines in 212 CIS patients was investigated using questionnaire and compared .Its influencing factors were analyzed by multivari‐ate linear regression analysis .Results The score of belief about medicines was 6 .06 ± 1 .86 in 212 CIS patients .The score of necessity belief was significantly higher than that of concern belief in CIS patients (16 .19 ± 2 .05 vs 10 .13 ± 1 .72 ,P<0 .01) .The score of belief about medicines dif‐fered greatly in CIS patients with different gender ,family income ,occupation ,NIHSS ,hemiplegia , aphasia ,drug taking time ,adverse effect of drugs and depression (P<0 .05) .Multivariate linear regression analysis showed that adverse effect of drugs ,depression ,NIHSS ,hemiplegia ,aphasia , occupation and gender were the influencing factors of belief about medicines in CIS patients (P<0 .05 ,P< 0 .01 ) .Conclusion T he belief about medicine is considerably poor in CIS patients , which is affected by a number of factors .Measures should thus be taken to improve their belief about medicines .