1.Oral sirolimus in the treatment of adult eruptive cherry angiomas
Christine Lyka R. Sayson, MD ; Aira Monica R. Abella, MD ; Danielle Marlo R. Senador, MD ; Leilani R. Senador, MD, FPDS ; Gisella U. Adasa, MD, FPDS
Journal of the Philippine Dermatological Society 2023;32(1):35-38
Introduction:
Cherry angiomas are a common type of acquired vascular proliferation of the skin which manifest as single or multiple
bright red spots that usually appear on the trunk and arms. They are generally asymptomatic; patients may opt to remove the lesions for
cosmetic reasons and prevention of bleeding. Conventionally, most cherry angiomas are treated with curettage, laser, and electrosurgery. Herein, we report a case of multiple cherry angiomas managed alternatively with oral sirolimus.
Case:
A 47-year-old Filipino female presented with a 10-month history of gradually enlarging multiple bright-red papules and
pedunculated nodules with a propensity to spontaneously bleed on gentle manipulation involving the scalp and forehead. Clinicopathological correlation suggests a diagnosis of eruptive cherry angiomas. The patient was started on oral sirolimus, a mammalian target of
rapamycin (mTOR) inhibitor.
Conclusion
We present a case of a patient with eruptive cherry angiomas who experienced significant decrease in size and bleeding
with treatment of oral sirolimus with minimal adverse effects. For patients with eruptive cherry angiomas, especially with contraindicated
comorbidities, first-line therapeutic option treatments with oral sirolimus can be beneficial.
sirolimus
;
vascular malformation
2.Acral lentiginous melanoma and tuberculosis verrucosa cutis in a 78-year-old Filipino: A case report
Danielle Marlo R. Senador ; Leilani R. Senador ; Johannes F. Dayrit ; Gisella U. Adasa
Journal of the Philippine Dermatological Society 2021;30(2):74-78
Introduction:
Acral lentiginous melanoma is a subtype of melanoma common in Asians with one of the worst prognoses. It is
usually detected late especially when situated on the plantar surface of the feet. While other forms of malignancies have been
associated with cutaneous tuberculosis, melanoma is not one of them.
Case report:
This is a case of a 78-year-old male with a six-month history of a solitary asymptomatic reddish-brown papule on
the plantar aspect of the right foot, which increased in size evolving into a verrucous plaque. There was no improvement despite
treatment with oral antibiotics and topical antifungals. Dermoscopic findings on different parts of the lesion were suggestive of
both a granulomatous disease and a melanoma. Purified Protein Derivative (PPD) skin test was positive. Histopathologic findings
showed the presence of multinucleated giant cells as well as nests of melanocytes which were highlighted by CD-68 and Melan-A
respectively. With clinicopathologic correlation, diagnosis of the patient was tuberculosis verrucosa cutis and acral lentiginous
melanoma. Complete excision with adequate margins was advised. The patient was started on a 6-month course of anti-Koch’s
medications and was referred to a surgery and oncology for co-management. The patient was subsequently lost to follow up,
until worsening of the lesions 6 months later prompted online consultation, claiming poor compliance to his anti-Koch’s regimen.
Patient was referred to a surgeon who did wide excision biopsy. Histopathologic findings were consistent with acral lentiginous
melanoma. Shortly after the procedure, the patient expired.
Conclusion
This is a rare case of acral lentiginous melanoma and tuberculosis verrucosa cutis existing concomitantly with
each other. This may also be presumed to be the first reported case of acral lentiginous melanoma arising from tuberculosis
verrucosa cutis.
Melanoma
;
Tuberculosis
;
Dermoscopy